Publication
Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)?
| Summary: | Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) is a new entity in which exposure to an adjuvant triggers an aberrant autoimmune response. Metallosis is a rare condition characterized by the deposition and build-up of metal debris in the soft tissues of the body associated with metal-on-metal (MOM) prosthetic devices. It can present with local/systemic symptoms and signs due to a chronic inflammatory host response. The authors present the case of a 51-year-old woman with a 6-month history of systemic complaints due to intoxication with metal ions from hip metallosis. This case highlights the importance of follow-up and continuous monitoring of patients with a hip prosthesis. As this is a rare condition, a patient presenting with unspecific symptoms such as ASIA syndrome induced by metallosis requires a high level of clinical suspicion as the removal of the adjuvant can resolve the condition. Learning points: Asia syndrome is a new entity in which exposure to an adjuvant triggers an aberrant autoimmune response.Metallosis is an uncommon condition with local and systemic presentation.A high level of suspicion and close monitoring is needed in patients with vague systemic complaints. |
|---|---|
| Main Authors: | Vaz, Rita Alexandra |
| Other Authors: | Xavier, Pedro; Brito, Sergio; Dantas, Jorge; Duque, Sofia; Consciência, Jose Guimarães; Campos, Luis |
| Subject: | ASIA syndrome Metallosis |
| Year: | 2019 |
| Country: | Portugal |
| Document type: | article |
| Access type: | restricted access |
| Associated institution: | Universidade de Lisboa |
| Language: | English |
| Origin: | Repositório da Universidade de Lisboa |
| _version_ | 1877773694768513024 |
|---|---|
| author | Vaz, Rita Alexandra |
| author2 | Xavier, Pedro Brito, Sergio Dantas, Jorge Duque, Sofia Consciência, Jose Guimarães Campos, Luis |
| author2_role | author author author author author author |
| author_facet | Vaz, Rita Alexandra Xavier, Pedro Brito, Sergio Dantas, Jorge Duque, Sofia Consciência, Jose Guimarães Campos, Luis |
| author_role | author |
| contributor_name_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Vaz, Rita Alexandra\"},{\"Person.name\":\"Xavier, Pedro\"},{\"Person.name\":\"Brito, Sergio\"},{\"Person.name\":\"Dantas, Jorge\"},{\"Person.name\":\"Duque, Sofia\",\"Person.identifier.orcid\":\"0000-0001-9273-5650\"},{\"Person.name\":\"Consciência, Jose Guimarães\"},{\"Person.name\":\"Campos, Luis\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| datacite.creators.creator.creatorName.fl_str_mv | Vaz, Rita Alexandra Xavier, Pedro Brito, Sergio Dantas, Jorge Duque, Sofia Consciência, Jose Guimarães Campos, Luis |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2022-08-24T14:00:51Z |
| datacite.date.embargoed.fl_str_mv | 2022-08-24T14:00:51Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | ASIA syndrome Metallosis |
| datacite.titles.title.fl_str_mv | Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? |
| dc.contributor.none.fl_str_mv | Repositório Científico de Acesso Aberto da ULisboa |
| dc.creator.none.fl_str_mv | Vaz, Rita Alexandra Xavier, Pedro Brito, Sergio Dantas, Jorge Duque, Sofia Consciência, Jose Guimarães Campos, Luis |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2022-08-24T14:00:51Z |
| dc.date.embargoed.fl_str_mv | 2022-08-24T14:00:51Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10451/54186 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | SMC media Srl |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | ASIA syndrome Metallosis |
| dc.title.fl_str_mv | Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) is a new entity in which exposure to an adjuvant triggers an aberrant autoimmune response. Metallosis is a rare condition characterized by the deposition and build-up of metal debris in the soft tissues of the body associated with metal-on-metal (MOM) prosthetic devices. It can present with local/systemic symptoms and signs due to a chronic inflammatory host response. The authors present the case of a 51-year-old woman with a 6-month history of systemic complaints due to intoxication with metal ions from hip metallosis. This case highlights the importance of follow-up and continuous monitoring of patients with a hip prosthesis. As this is a rare condition, a patient presenting with unspecific symptoms such as ASIA syndrome induced by metallosis requires a high level of clinical suspicion as the removal of the adjuvant can resolve the condition. Learning points: Asia syndrome is a new entity in which exposure to an adjuvant triggers an aberrant autoimmune response.Metallosis is an uncommon condition with local and systemic presentation.A high level of suspicion and close monitoring is needed in patients with vague systemic complaints. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ulisboa.pt/bitstreams/d9e1ba4b-66c7-4683-9a67-981eeab7bbfe/download |
| id | ul_7ca843311b6728f71f40ea030f95370b |
| identifier.url.fl_str_mv | http://hdl.handle.net/10451/54186 |
| inst_facet_str | urn:organizationAcronym:ul{{{_:::_}}}Universidade de Lisboa |
| instacron_str | ul |
| institution | Universidade de Lisboa |
| instname_str | Universidade de Lisboa |
| language | eng |
| network_acronym_str | ul |
| network_name_str | Repositório da Universidade de Lisboa |
| oai_identifier_str | oai:repositorio.ulisboa.pt:10451/54186 |
| organization_str_mv | urn:organizationAcronym:ul |
| person_str_mv | Vaz, Rita Alexandra Xavier, Pedro Brito, Sergio Dantas, Jorge Duque, Sofia Duque, Sofia http://orcid.org/0000-0001-9273-5650 0000-0001-9273-5650 Consciência, Jose Guimarães Campos, Luis |
| publishDate | 2019 |
| publisher.none.fl_str_mv | SMC media Srl |
| repo_facet_str | urn:repositoryAcronym:ul{{{_:::_}}}Repositório da Universidade de Lisboa |
| reponame_str | Repositório da Universidade de Lisboa |
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| service_str_mv | urn:repositoryAcronym:ul |
| spelling | engSMC media Srlpt_PTAutoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) is a new entity in which exposure to an adjuvant triggers an aberrant autoimmune response. Metallosis is a rare condition characterized by the deposition and build-up of metal debris in the soft tissues of the body associated with metal-on-metal (MOM) prosthetic devices. It can present with local/systemic symptoms and signs due to a chronic inflammatory host response. The authors present the case of a 51-year-old woman with a 6-month history of systemic complaints due to intoxication with metal ions from hip metallosis. This case highlights the importance of follow-up and continuous monitoring of patients with a hip prosthesis. As this is a rare condition, a patient presenting with unspecific symptoms such as ASIA syndrome induced by metallosis requires a high level of clinical suspicion as the removal of the adjuvant can resolve the condition. Learning points: Asia syndrome is a new entity in which exposure to an adjuvant triggers an aberrant autoimmune response.Metallosis is an uncommon condition with local and systemic presentation.A high level of suspicion and close monitoring is needed in patients with vague systemic complaints.application/pdfpt_PTMetallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)?Vaz, Rita AlexandraXavier, PedroBrito, SergioDantas, JorgePersonalDuque, SofiaDSpacehttp://dspace.org/items/1296c490-8ae2-4a78-abee-b668a0cb02a6DSpacehttp://dspace.org/items/1296c490-8ae2-4a78-abee-b668a0cb02a6DuqueSofiaORCIDhttp://orcid.org0000-0001-9273-5650Consciência, Jose GuimarãesCampos, LuisHostingInstitutionOrganizationalRepositório Científico de Acesso Aberto da ULisboae-mailmailto:repositorio@ulisboa.ptrepositorio@ulisboa.ptISSNIsPartOf2284-2594DOIIsPartOf10.12890/2019_0010342022-08-24T14:00:51Z20192019-01-01T00:00:00ZHandlehttp://hdl.handle.net/10451/54186http://purl.org/coar/access_right/c_16ecrestricted accessASIA syndromeMetallosis241310 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://repositorio.ulisboa.pt/bitstreams/d9e1ba4b-66c7-4683-9a67-981eeab7bbfe/downloadEuropean Journal of Case Reports in Internal Medicine63 |
| spellingShingle | Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? Vaz, Rita Alexandra ASIA syndrome Metallosis |
| status | SINGLETON |
| subject.fl_str_mv | ASIA syndrome Metallosis |
| title | Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? |
| title_full | Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? |
| title_fullStr | Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? |
| title_full_unstemmed | Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? |
| title_short | Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? |
| title_sort | Metallosis: a new form of autoimmune/autoinflammatory syndrome induced by adjuvants syndrome (ASIA)? |
| topic | ASIA syndrome Metallosis |
| topic_facet | ASIA syndrome Metallosis |
| url | http://hdl.handle.net/10451/54186 |
| visible | 1 |
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