Publicação
Development of a novel hydrogel for skin regeneration
| Resumo: | Skin lesions are traumatic events that lead to increased fluid loss, infections, scars formation and the appearance of immunocompromised regions. The loss of skin integrity can result in significant physiological imbalances and disability or even death. So far, different wound dressings have been developed. Among them, hydrogels are the most applied. Herein, a thermoresponsive hydrogel was produced using chitosan and agarose formed at body temperature (37°C), in order to verify their applicability in the treatment of wounds. Hydrogel bactericidal activity, biocompatibility, morphology, porosity and wettability were characterized by confocal microscopy, MTS assay and SEM. The attained results revealed that hydrogel has a pore size (90–400 µm) compatible with cellular internalization and proliferation. A bactericidal activity was observed for hydrogels containing more than 188 µg/mL of chitosan. The results obtained demonstrated that this 3D network has the suitable properties for improving the healing process of cutaneous wounds. |
|---|---|
| Autores principais: | Miguel, Sónia P. |
| Outros Autores: | Ribeiro, MP.; Correia, Ilídio Joaquim Sobreira |
| Assunto: | Hydrogel Skin |
| Ano: | 2014 |
| País: | Portugal |
| Tipo de documento: | livro |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade da Beira Interior |
| Idioma: | inglês |
| Origem: | uBibliorum |
| _version_ | 1868420775800733696 |
|---|---|
| author | Miguel, Sónia P. |
| author2 | Ribeiro, MP. Correia, Ilídio Joaquim Sobreira |
| author2_role | author author |
| author_facet | Miguel, Sónia P. Ribeiro, MP. Correia, Ilídio Joaquim Sobreira |
| author_role | author |
| contributor_name_str_mv | uBibliorum |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Miguel, Sónia P.\",\"Person.identifier.orcid\":\"0000-0001-7274-0399\"},{\"Person.name\":\"Ribeiro, MP.\",\"Person.identifier.orcid\":\"0000-0001-6357-8115\"},{\"Person.name\":\"Correia, Ilídio Joaquim Sobreira\",\"Person.identifier.orcid\":\"0000-0003-1613-9675\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | uBibliorum |
| datacite.creators.creator.creatorName.fl_str_mv | Miguel, Sónia P. Ribeiro, MP. Correia, Ilídio Joaquim Sobreira |
| datacite.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-04-13T09:29:58Z |
| datacite.date.embargoed.fl_str_mv | 2018-04-13T09:29:58Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Hydrogel Skin |
| datacite.titles.title.fl_str_mv | Development of a novel hydrogel for skin regeneration |
| dc.contributor.none.fl_str_mv | uBibliorum |
| dc.creator.none.fl_str_mv | Miguel, Sónia P. Ribeiro, MP. Correia, Ilídio Joaquim Sobreira |
| dc.date.Accepted.fl_str_mv | 2014-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-04-13T09:29:58Z |
| dc.date.embargoed.fl_str_mv | 2018-04-13T09:29:58Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.6/4739 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Lambert Academic Publishing |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Hydrogel Skin |
| dc.title.fl_str_mv | Development of a novel hydrogel for skin regeneration |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_2f33 |
| description | Skin lesions are traumatic events that lead to increased fluid loss, infections, scars formation and the appearance of immunocompromised regions. The loss of skin integrity can result in significant physiological imbalances and disability or even death. So far, different wound dressings have been developed. Among them, hydrogels are the most applied. Herein, a thermoresponsive hydrogel was produced using chitosan and agarose formed at body temperature (37°C), in order to verify their applicability in the treatment of wounds. Hydrogel bactericidal activity, biocompatibility, morphology, porosity and wettability were characterized by confocal microscopy, MTS assay and SEM. The attained results revealed that hydrogel has a pore size (90–400 µm) compatible with cellular internalization and proliferation. A bactericidal activity was observed for hydrogels containing more than 188 µg/mL of chitosan. The results obtained demonstrated that this 3D network has the suitable properties for improving the healing process of cutaneous wounds. |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10400.6/4739 |
| instacron_str | ubi |
| institution | Universidade da Beira Interior |
| instname_str | Universidade da Beira Interior |
| language | eng |
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| oai_identifier_str | oai:ubibliorum.ubi.pt:10400.6/4739 |
| organization_str_mv | urn:organizationAcronym:ubi |
| person_str_mv | Miguel, Sónia P. Miguel, Sónia P. https://www.ciencia-id.pt/1A13-ABC0-C32C 1A13-ABC0-C32C http://orcid.org/0000-0001-7274-0399 0000-0001-7274-0399 Ribeiro, MP. Ribeiro, MP. https://www.ciencia-id.pt/BD11-6497-FD37 BD11-6497-FD37 http://orcid.org/0000-0001-6357-8115 0000-0001-6357-8115 Correia, Ilídio Joaquim Sobreira Correia, Ilídio Joaquim Sobreira https://www.ciencia-id.pt/F610-7373-DC81 F610-7373-DC81 http://orcid.org/0000-0003-1613-9675 0000-0003-1613-9675 |
| publishDate | 2014 |
| publisher.none.fl_str_mv | Lambert Academic Publishing |
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| spelling | engLambert Academic Publishingpt_PTSkin lesions are traumatic events that lead to increased fluid loss, infections, scars formation and the appearance of immunocompromised regions. The loss of skin integrity can result in significant physiological imbalances and disability or even death. So far, different wound dressings have been developed. Among them, hydrogels are the most applied. Herein, a thermoresponsive hydrogel was produced using chitosan and agarose formed at body temperature (37°C), in order to verify their applicability in the treatment of wounds. Hydrogel bactericidal activity, biocompatibility, morphology, porosity and wettability were characterized by confocal microscopy, MTS assay and SEM. The attained results revealed that hydrogel has a pore size (90–400 µm) compatible with cellular internalization and proliferation. A bactericidal activity was observed for hydrogels containing more than 188 µg/mL of chitosan. The results obtained demonstrated that this 3D network has the suitable properties for improving the healing process of cutaneous wounds.application/pdfpt_PTDevelopment of a novel hydrogel for skin regenerationPersonalMiguel, Sónia P.DSpacehttp://dspace.org/items/3956033a-4abf-439b-a4fd-25c5bd9d8e7aDSpacehttp://dspace.org/items/3956033a-4abf-439b-a4fd-25c5bd9d8e7aPereira MiguelSónia AlexandraCiência IDhttps://www.ciencia-id.pt1A13-ABC0-C32CORCIDhttp://orcid.org0000-0001-7274-0399Scopus Author IDhttps://www.scopus.com55638166400PersonalRibeiro, MP.DSpacehttp://dspace.org/items/3fe7a59f-e867-4bed-bb6e-7d7631330af5DSpacehttp://dspace.org/items/3fe7a59f-e867-4bed-bb6e-7d7631330af5RibeiroMaximiano José PrataCiência IDhttps://www.ciencia-id.ptBD11-6497-FD37ORCIDhttp://orcid.org0000-0001-6357-8115Scopus Author IDhttps://www.scopus.com26658759200PersonalCorreia, Ilídio Joaquim SobreiraDSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adDSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adCorreiaIlídio Joaquim SobreiraCiência IDhttps://www.ciencia-id.ptF610-7373-DC81ORCIDhttp://orcid.org0000-0003-1613-9675Scopus Author IDhttps://www.scopus.com7003557499HostingInstitutionOrganizationaluBibliorume-mailmailto:noreplyuBibliorum@ubi.ptnoreplyuBibliorum@ubi.ptISBNIsPartOf978-3-659-59717-62018-04-13T09:29:58Z20142014-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.6/4739http://purl.org/coar/access_right/c_16ecrestricted accessHydrogelSkin9384118 bytesliteraturehttp://purl.org/coar/resource_type/c_2f33bookhttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://ubibliorum.ubi.pt/bitstreams/9479fb24-6cae-4d34-ac89-8c9a6d2e1c28/download |
| spellingShingle | Development of a novel hydrogel for skin regeneration Miguel, Sónia P. Hydrogel Skin |
| status | SINGLETON |
| subject.fl_str_mv | Hydrogel Skin |
| title | Development of a novel hydrogel for skin regeneration |
| title_full | Development of a novel hydrogel for skin regeneration |
| title_fullStr | Development of a novel hydrogel for skin regeneration |
| title_full_unstemmed | Development of a novel hydrogel for skin regeneration |
| title_short | Development of a novel hydrogel for skin regeneration |
| title_sort | Development of a novel hydrogel for skin regeneration |
| topic | Hydrogel Skin |
| topic_facet | Hydrogel Skin |
| url | http://hdl.handle.net/10400.6/4739 |
| visible | 1 |
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