Publicação
Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review
| Resumo: | Multiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, the outcome of chemotherapeutic regimens remains impaired by the drugs’ weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered the development of nanomaterials to encapsulate and deliver anticancer drugs. In fact, the loading of drugs into nanoparticles can overcome most of the solubility concerns. However, the ability of systemically administered drug-loaded nanomaterials to reach the tumor site has been vastly overestimated, limiting their clinical translation. The drugs’ and drug-loaded nanomaterials’ systemic administration issues have propelled the development of hydrogels capable of performing their direct/local delivery into the tumor site. The use of these macroscale systems to mediate a tumor-confined delivery of the drugs/drugs-loaded nanomaterials grants an improved therapeutic efficacy and, simultaneously, a reduction of the side effects. The manufacture of these hydrogels requires the careful selection and tailoring of specific polymers/materials as well as the choice of appropriate physical and/or chemical crosslinking interactions. Depending on their administration route and assembling process, these matrices can be classified as injectable in situ forming hydrogels, injectable shear-thinning/selfhealing hydrogels, and implantable hydrogels, each type bringing a plethora of advantages for the intended biomedical application. This review provides the reader with an insight into the application of injectable and implantable hydrogels for performing the tumor-confined delivery of drugs and drug-loaded nanomaterials. |
|---|---|
| Autores principais: | Pouso, Manuel António do Rosário |
| Outros Autores: | Melo, Bruna Daniela Lopes; Gonçalves, Joaquim; Louro, Ricardo; Mendonça, António; Correia, Ilídio Joaquim Sobreira; de Melo-Diogo, Duarte |
| Assunto: | Cancer Therapy Drug delivery systems Implantable hydrogels Injectable hydrogels Local chemotherapy Local delivery Nanomaterials |
| Ano: | 2025 |
| País: | Portugal |
| Tipo de documento: | artigo de revisão |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade da Beira Interior |
| Idioma: | inglês |
| Origem: | uBibliorum |
| _version_ | 1868420823406084096 |
|---|---|
| author | Pouso, Manuel António do Rosário |
| author2 | Melo, Bruna Daniela Lopes Gonçalves, Joaquim Louro, Ricardo Mendonça, António Correia, Ilídio Joaquim Sobreira de Melo-Diogo, Duarte |
| author2_role | author author author author author author |
| author_facet | Pouso, Manuel António do Rosário Melo, Bruna Daniela Lopes Gonçalves, Joaquim Louro, Ricardo Mendonça, António Correia, Ilídio Joaquim Sobreira de Melo-Diogo, Duarte |
| author_role | author |
| contributor_name_str_mv | uBibliorum |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pouso, Manuel António do Rosário\",\"Person.identifier.orcid\":\"0000-0001-9816-6284\"},{\"Person.name\":\"Melo, Bruna Daniela Lopes\",\"Person.identifier.orcid\":\"0000-0002-0078-1877\"},{\"Person.name\":\"Gonçalves, Joaquim\",\"Person.identifier.orcid\":\"0009-0008-2314-701X\"},{\"Person.name\":\"Louro, Ricardo\",\"Person.identifier.orcid\":\"0000-0002-2392-6450\"},{\"Person.name\":\"Mendonça, António\",\"Person.identifier.orcid\":\"0000-0001-8069-0440\"},{\"Person.name\":\"Correia, Ilídio Joaquim Sobreira\",\"Person.identifier.orcid\":\"0000-0003-1613-9675\"},{\"Person.name\":\"de Melo-Diogo, Duarte\",\"Person.identifier.orcid\":\"0000-0001-9984-3603\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | uBibliorum |
| datacite.creators.creator.creatorName.fl_str_mv | Pouso, Manuel António do Rosário Melo, Bruna Daniela Lopes Gonçalves, Joaquim Louro, Ricardo Mendonça, António Correia, Ilídio Joaquim Sobreira de Melo-Diogo, Duarte |
| datacite.date.Accepted.fl_str_mv | 2025-04-24T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-10-02T10:50:31Z |
| datacite.date.embargoed.fl_str_mv | 2025-10-02T10:50:31Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Cancer Therapy Drug delivery systems Implantable hydrogels Injectable hydrogels Local chemotherapy Local delivery Nanomaterials |
| datacite.titles.title.fl_str_mv | Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review |
| dc.contributor.none.fl_str_mv | uBibliorum |
| dc.creator.none.fl_str_mv | Pouso, Manuel António do Rosário Melo, Bruna Daniela Lopes Gonçalves, Joaquim Louro, Ricardo Mendonça, António Correia, Ilídio Joaquim Sobreira de Melo-Diogo, Duarte |
| dc.date.Accepted.fl_str_mv | 2025-04-24T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-10-02T10:50:31Z |
| dc.date.embargoed.fl_str_mv | 2025-10-02T10:50:31Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.6/18941 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Cancer Therapy Drug delivery systems Implantable hydrogels Injectable hydrogels Local chemotherapy Local delivery Nanomaterials |
| dc.title.fl_str_mv | Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_dcae04bc |
| description | Multiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, the outcome of chemotherapeutic regimens remains impaired by the drugs’ weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered the development of nanomaterials to encapsulate and deliver anticancer drugs. In fact, the loading of drugs into nanoparticles can overcome most of the solubility concerns. However, the ability of systemically administered drug-loaded nanomaterials to reach the tumor site has been vastly overestimated, limiting their clinical translation. The drugs’ and drug-loaded nanomaterials’ systemic administration issues have propelled the development of hydrogels capable of performing their direct/local delivery into the tumor site. The use of these macroscale systems to mediate a tumor-confined delivery of the drugs/drugs-loaded nanomaterials grants an improved therapeutic efficacy and, simultaneously, a reduction of the side effects. The manufacture of these hydrogels requires the careful selection and tailoring of specific polymers/materials as well as the choice of appropriate physical and/or chemical crosslinking interactions. Depending on their administration route and assembling process, these matrices can be classified as injectable in situ forming hydrogels, injectable shear-thinning/selfhealing hydrogels, and implantable hydrogels, each type bringing a plethora of advantages for the intended biomedical application. This review provides the reader with an insight into the application of injectable and implantable hydrogels for performing the tumor-confined delivery of drugs and drug-loaded nanomaterials. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | reviewArticle |
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| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
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| person_str_mv | Pouso, Manuel António do Rosário Pouso, Manuel António do Rosário https://www.ciencia-id.pt/EB15-3F85-263D EB15-3F85-263D http://orcid.org/0000-0001-9816-6284 0000-0001-9816-6284 Melo, Bruna Daniela Lopes Melo, Bruna Daniela Lopes https://www.ciencia-id.pt/5717-CB52-B4E5 5717-CB52-B4E5 http://orcid.org/0000-0002-0078-1877 0000-0002-0078-1877 Gonçalves, Joaquim Gonçalves, Joaquim https://www.ciencia-id.pt/A613-7659-3BA9 A613-7659-3BA9 http://orcid.org/0009-0008-2314-701X 0009-0008-2314-701X Louro, Ricardo Louro, Ricardo http://orcid.org/0000-0002-2392-6450 0000-0002-2392-6450 Mendonça, António Mendonça, António https://www.ciencia-id.pt/2419-6E20-F958 2419-6E20-F958 http://orcid.org/0000-0001-8069-0440 0000-0001-8069-0440 Correia, Ilídio Joaquim Sobreira Correia, Ilídio Joaquim Sobreira https://www.ciencia-id.pt/F610-7373-DC81 F610-7373-DC81 http://orcid.org/0000-0003-1613-9675 0000-0003-1613-9675 de Melo-Diogo, Duarte de Melo-Diogo, Duarte https://www.ciencia-id.pt/9C10-9BD8-634E 9C10-9BD8-634E http://orcid.org/0000-0001-9984-3603 0000-0001-9984-3603 |
| publishDate | 2025 |
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| spelling | engElsevierengMultiple chemotherapeutic strategies have been developed to tackle the complexity of cancer. Still, the outcome of chemotherapeutic regimens remains impaired by the drugs’ weak solubility, unspecific biodistribution and poor tumor accumulation after systemic administration. Such constraints triggered the development of nanomaterials to encapsulate and deliver anticancer drugs. In fact, the loading of drugs into nanoparticles can overcome most of the solubility concerns. However, the ability of systemically administered drug-loaded nanomaterials to reach the tumor site has been vastly overestimated, limiting their clinical translation. The drugs’ and drug-loaded nanomaterials’ systemic administration issues have propelled the development of hydrogels capable of performing their direct/local delivery into the tumor site. The use of these macroscale systems to mediate a tumor-confined delivery of the drugs/drugs-loaded nanomaterials grants an improved therapeutic efficacy and, simultaneously, a reduction of the side effects. The manufacture of these hydrogels requires the careful selection and tailoring of specific polymers/materials as well as the choice of appropriate physical and/or chemical crosslinking interactions. Depending on their administration route and assembling process, these matrices can be classified as injectable in situ forming hydrogels, injectable shear-thinning/selfhealing hydrogels, and implantable hydrogels, each type bringing a plethora of advantages for the intended biomedical application. This review provides the reader with an insight into the application of injectable and implantable hydrogels for performing the tumor-confined delivery of drugs and drug-loaded nanomaterials.application/pdfporInjectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A reviewPersonalPouso, Manuel António do RosárioDSpacehttp://dspace.org/items/f4166921-0e42-421a-960c-b38e969fc0b0DSpacehttp://dspace.org/items/f4166921-0e42-421a-960c-b38e969fc0b0PousoManuel António do RosárioCiência IDhttps://www.ciencia-id.ptEB15-3F85-263DORCIDhttp://orcid.org0000-0001-9816-6284PersonalMelo, Bruna Daniela LopesDSpacehttp://dspace.org/items/d375e555-1edb-4f4e-b888-9973932767ffDSpacehttp://dspace.org/items/d375e555-1edb-4f4e-b888-9973932767ffMeloBruna Daniela LopesCiência IDhttps://www.ciencia-id.pt5717-CB52-B4E5ORCIDhttp://orcid.org0000-0002-0078-1877PersonalGonçalves, JoaquimDSpacehttp://dspace.org/items/6681349e-e581-4a26-9d83-02ca4cbae502DSpacehttp://dspace.org/items/6681349e-e581-4a26-9d83-02ca4cbae502GonçalvesJoaquimCiência IDhttps://www.ciencia-id.ptA613-7659-3BA9ORCIDhttp://orcid.org0009-0008-2314-701XPersonalLouro, RicardoDSpacehttp://dspace.org/items/773007f7-2373-4bc9-87bc-a8acb3cc6309DSpacehttp://dspace.org/items/773007f7-2373-4bc9-87bc-a8acb3cc6309LouroRicardoORCIDhttp://orcid.org0000-0002-2392-6450Scopus Author IDhttps://www.scopus.com6603724134PersonalMendonça, AntónioDSpacehttp://dspace.org/items/fbccceb8-2850-4fe1-ae4f-4aeded7bf32aDSpacehttp://dspace.org/items/fbccceb8-2850-4fe1-ae4f-4aeded7bf32aMendonçaAntónioCiência IDhttps://www.ciencia-id.pt2419-6E20-F958ORCIDhttp://orcid.org0000-0001-8069-0440Researcher IDhttps://www.researcherid.comI-3093-2012Scopus Author IDhttps://www.scopus.com56890866600PersonalCorreia, Ilídio Joaquim SobreiraDSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adDSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adCorreiaIlídio Joaquim SobreiraCiência IDhttps://www.ciencia-id.ptF610-7373-DC81ORCIDhttp://orcid.org0000-0003-1613-9675Scopus Author IDhttps://www.scopus.com7003557499Personalde Melo-Diogo, DuarteDSpacehttp://dspace.org/items/8525f1be-ff8f-4e46-b158-e59928e8a3e5DSpacehttp://dspace.org/items/8525f1be-ff8f-4e46-b158-e59928e8a3e5de Melo-DiogoDuarteCiência IDhttps://www.ciencia-id.pt9C10-9BD8-634EORCIDhttp://orcid.org0000-0001-9984-3603Scopus Author IDhttps://www.scopus.com56266511300HostingInstitutionOrganizationaluBibliorume-mailmailto:noreplyuBibliorum@ubi.ptnoreplyuBibliorum@ubi.ptISSNIsPartOf1873-3476DOIIsPartOfhttps://doi.org/10.1016/j.ijpharm.2025.1256402025-10-02T10:50:31Z2025-04-242025-04-24T00:00:00ZHandlehttp://hdl.handle.net/10400.6/18941http://purl.org/coar/access_right/c_abf2open accessCancer TherapyDrug delivery systemsImplantable hydrogelsInjectable hydrogelsLocal chemotherapyLocal deliveryNanomaterials10753065 bytesFundação para a Ciência e a TecnologiaShear-thinning and self-healing hydrogels: tuning the polymer-related features for the tumor confined delivery of therapeutics aimed for metastatic breast cancer immuno-photothermal therapy [2021.00590.CEECIND/CP1661/CT0001]info:eu-repo/grantAgreement/FCT/CEEC IND4ed/2021.00590.CEECIND%2FCP1661%2FCT0001/PT2021.00590.CEECIND/CP1661/CT0001CEEC IND4edCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaHealth Sciences Research Centre [UIDP/00709/2020]info:eu-repo/grantAgreement/FCT/6817 - 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| spellingShingle | Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review Pouso, Manuel António do Rosário Cancer Therapy Drug delivery systems Implantable hydrogels Injectable hydrogels Local chemotherapy Local delivery Nanomaterials |
| status | SINGLETON |
| subject.fl_str_mv | Cancer Therapy Drug delivery systems Implantable hydrogels Injectable hydrogels Local chemotherapy Local delivery Nanomaterials |
| title | Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review |
| title_full | Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review |
| title_fullStr | Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review |
| title_full_unstemmed | Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review |
| title_short | Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review |
| title_sort | Injectable and implantable hydrogels for localized delivery of drugs and nanomaterials for cancer chemotherapy: A review |
| topic | Cancer Therapy Drug delivery systems Implantable hydrogels Injectable hydrogels Local chemotherapy Local delivery Nanomaterials |
| topic_facet | Cancer Therapy Drug delivery systems Implantable hydrogels Injectable hydrogels Local chemotherapy Local delivery Nanomaterials |
| url | http://hdl.handle.net/10400.6/18941 |
| visible | 1 |