Publicação
IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy
| Resumo: | Gold core silica shell (AuMSS) nanorods present excellent physicochemical proper-ties that allow their application as photothermal and drug delivery agents. Herein,AuMSS nanorods were dual‐functionalized with Polyethylene glycol methyl ether(PEG‐CH3) and Gelatin (GEL) to enhance both the colloidal stability and uptake byHeLa cancer cells. Additionally, the AuMSS nanorods were combined for the firsttime with IR780 (a heptamethine cyanine molecule) and its photothermal and pho-todynamic capacities were determined. The obtained results reveal that the en-capsulation of IR780 (65 μg per AuMSS mg) increases the photothermal conversionefficiency of AuMSS nanorods by 10%, and this enhanced heat generation wasmaintained even after three irradiation cycles with a NIR (808 nm) laser. Moreover,the IR780‐loaded AuMSS/T‐PEG‐CH3/T‐GEL presented≈2‐times higher uptake inHeLa cells, when compared to the non‐coated counterparts, and successfullymediated the light‐triggered generation of reactive oxygen species. Overall, thecombination of photodynamic and photothermal therapy mediated by IR780‐loadedAuMSS/T‐PEG‐CH3/T‐GEL nanorods effectively promoted the ablation of HeLacancer cells. |
|---|---|
| Autores principais: | Gonçalves, Ariana |
| Outros Autores: | Rodrigues, Ana Carolina Félix; Fernandes, Natanael; Diogo, Duarte de Melo; Ferreira, Paula; Moreira, André F.; Correia, I.J. |
| Assunto: | Gelatin Gold core silica shell nanoparticles IR780 PEG‐CH3 Photodynamic therapy Photothermal therapy |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade da Beira Interior |
| Idioma: | inglês |
| Origem: | uBibliorum |
| _version_ | 1868420752533880832 |
|---|---|
| author | Gonçalves, Ariana |
| author2 | Rodrigues, Ana Carolina Félix Fernandes, Natanael Diogo, Duarte de Melo Ferreira, Paula Moreira, André F. Correia, I.J. |
| author2_role | author author author author author author |
| author_facet | Gonçalves, Ariana Rodrigues, Ana Carolina Félix Fernandes, Natanael Diogo, Duarte de Melo Ferreira, Paula Moreira, André F. Correia, I.J. |
| author_role | author |
| contributor_name_str_mv | uBibliorum |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Gonçalves, Ariana\",\"Person.identifier.orcid\":\"0000-0001-7408-1331\"},{\"Person.name\":\"Rodrigues, Ana Carolina Félix\",\"Person.identifier.orcid\":\"0000-0002-5493-8331\"},{\"Person.name\":\"Fernandes, Natanael\",\"Person.identifier.orcid\":\"0000-0002-7737-9288\"},{\"Person.name\":\"Diogo, Duarte de Melo\",\"Person.identifier.orcid\":\"0000-0001-9984-3603\"},{\"Person.name\":\"Ferreira, Paula\",\"Person.identifier.orcid\":\"0000-0003-3393-4427\"},{\"Person.name\":\"Moreira, André F.\",\"Person.identifier.orcid\":\"0000-0002-0604-2506\"},{\"Person.name\":\"Correia, I.J.\",\"Person.identifier.orcid\":\"0000-0003-1613-9675\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | uBibliorum |
| datacite.creators.creator.creatorName.fl_str_mv | Gonçalves, Ariana Rodrigues, Ana Carolina Félix Fernandes, Natanael Diogo, Duarte de Melo Ferreira, Paula Moreira, André F. Correia, I.J. |
| datacite.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-01-03T01:30:20Z |
| datacite.date.embargoed.fl_str_mv | 2025-01-03T01:30:20Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Gelatin Gold core silica shell nanoparticles IR780 PEG‐CH3 Photodynamic therapy Photothermal therapy |
| datacite.titles.title.fl_str_mv | IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy |
| dc.contributor.none.fl_str_mv | uBibliorum |
| dc.creator.none.fl_str_mv | Gonçalves, Ariana Rodrigues, Ana Carolina Félix Fernandes, Natanael Diogo, Duarte de Melo Ferreira, Paula Moreira, André F. Correia, I.J. |
| dc.date.Accepted.fl_str_mv | 2021-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-01-03T01:30:20Z |
| dc.date.embargoed.fl_str_mv | 2025-01-03T01:30:20Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.6/12573 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | wiley |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Gelatin Gold core silica shell nanoparticles IR780 PEG‐CH3 Photodynamic therapy Photothermal therapy |
| dc.title.fl_str_mv | IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Gold core silica shell (AuMSS) nanorods present excellent physicochemical proper-ties that allow their application as photothermal and drug delivery agents. Herein,AuMSS nanorods were dual‐functionalized with Polyethylene glycol methyl ether(PEG‐CH3) and Gelatin (GEL) to enhance both the colloidal stability and uptake byHeLa cancer cells. Additionally, the AuMSS nanorods were combined for the firsttime with IR780 (a heptamethine cyanine molecule) and its photothermal and pho-todynamic capacities were determined. The obtained results reveal that the en-capsulation of IR780 (65 μg per AuMSS mg) increases the photothermal conversionefficiency of AuMSS nanorods by 10%, and this enhanced heat generation wasmaintained even after three irradiation cycles with a NIR (808 nm) laser. Moreover,the IR780‐loaded AuMSS/T‐PEG‐CH3/T‐GEL presented≈2‐times higher uptake inHeLa cells, when compared to the non‐coated counterparts, and successfullymediated the light‐triggered generation of reactive oxygen species. Overall, thecombination of photodynamic and photothermal therapy mediated by IR780‐loadedAuMSS/T‐PEG‐CH3/T‐GEL nanorods effectively promoted the ablation of HeLacancer cells. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://ubibliorum.ubi.pt/bitstreams/b547994e-bcbb-4267-90d4-7e092e82c5d3/download |
| funding.funder.alternateName_str_mv | FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.identifier_str_mv | SFRH/BD/144680/2019 UIDB/00709/2020 |
| funding.name_str_mv | Bolsa de Doutoramento 6817 - DCRRNI ID |
| funding_str_mv | SFRH/BD/144680/2019 info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PT UIDB/00709/2020 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PT |
| id | ubibliorum_d752cfa0404b4dbcfe2ecec79d93f97e |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.6/12573 |
| instacron_str | ubi |
| institution | Universidade da Beira Interior |
| instname_str | Universidade da Beira Interior |
| language | eng |
| network_acronym_str | ubibliorum |
| network_name_str | uBibliorum |
| oai_identifier_str | oai:ubibliorum.ubi.pt:10400.6/12573 |
| organization_str_mv | urn:organizationAcronym:ubi |
| person_str_mv | Gonçalves, Ariana Gonçalves, Ariana https://www.ciencia-id.pt/031A-CDE6-6457 031A-CDE6-6457 http://orcid.org/0000-0001-7408-1331 0000-0001-7408-1331 Rodrigues, Ana Carolina Félix Rodrigues, Ana Carolina Félix https://www.ciencia-id.pt/3D14-BE84-E5CD 3D14-BE84-E5CD http://orcid.org/0000-0002-5493-8331 0000-0002-5493-8331 Fernandes, Natanael Fernandes, Natanael https://www.ciencia-id.pt/2315-CC5A-3DBB 2315-CC5A-3DBB http://orcid.org/0000-0002-7737-9288 0000-0002-7737-9288 Diogo, Duarte de Melo Diogo, Duarte de Melo https://www.ciencia-id.pt/9C10-9BD8-634E 9C10-9BD8-634E http://orcid.org/0000-0001-9984-3603 0000-0001-9984-3603 Ferreira, Paula Ferreira, Paula https://www.ciencia-id.pt/A119-FFB8-0899 A119-FFB8-0899 http://orcid.org/0000-0003-3393-4427 0000-0003-3393-4427 Moreira, André F. Moreira, André F. https://www.ciencia-id.pt/4C1E-012B-83CE 4C1E-012B-83CE http://orcid.org/0000-0002-0604-2506 0000-0002-0604-2506 Correia, I.J. Correia, I.J. https://www.ciencia-id.pt/F610-7373-DC81 F610-7373-DC81 http://orcid.org/0000-0003-1613-9675 0000-0003-1613-9675 |
| publishDate | 2021 |
| publisher.none.fl_str_mv | wiley |
| reponame_str | uBibliorum |
| repository_id_str | urn:repositoryAcronym:ubibliorum |
| service_str_mv | urn:repositoryAcronym:ubibliorum |
| spelling | engwileypt_PTGold core silica shell (AuMSS) nanorods present excellent physicochemical proper-ties that allow their application as photothermal and drug delivery agents. Herein,AuMSS nanorods were dual‐functionalized with Polyethylene glycol methyl ether(PEG‐CH3) and Gelatin (GEL) to enhance both the colloidal stability and uptake byHeLa cancer cells. Additionally, the AuMSS nanorods were combined for the firsttime with IR780 (a heptamethine cyanine molecule) and its photothermal and pho-todynamic capacities were determined. The obtained results reveal that the en-capsulation of IR780 (65 μg per AuMSS mg) increases the photothermal conversionefficiency of AuMSS nanorods by 10%, and this enhanced heat generation wasmaintained even after three irradiation cycles with a NIR (808 nm) laser. Moreover,the IR780‐loaded AuMSS/T‐PEG‐CH3/T‐GEL presented≈2‐times higher uptake inHeLa cells, when compared to the non‐coated counterparts, and successfullymediated the light‐triggered generation of reactive oxygen species. Overall, thecombination of photodynamic and photothermal therapy mediated by IR780‐loadedAuMSS/T‐PEG‐CH3/T‐GEL nanorods effectively promoted the ablation of HeLacancer cells.application/pdfpt_PTIR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapyPersonalGonçalves, ArianaDSpacehttp://dspace.org/items/f3e03091-7605-4411-9fce-5e2edc49d269DSpacehttp://dspace.org/items/f3e03091-7605-4411-9fce-5e2edc49d269GonçalvesArianaCiência IDhttps://www.ciencia-id.pt031A-CDE6-6457ORCIDhttp://orcid.org0000-0001-7408-1331PersonalRodrigues, Ana Carolina FélixDSpacehttp://dspace.org/items/5c78ad01-afa8-470c-b674-0892eeed6534DSpacehttp://dspace.org/items/5c78ad01-afa8-470c-b674-0892eeed6534Félix RodriguesAna CarolinaCiência IDhttps://www.ciencia-id.pt3D14-BE84-E5CDORCIDhttp://orcid.org0000-0002-5493-8331Scopus Author IDhttps://www.scopus.com57202076016PersonalFernandes, NatanaelDSpacehttp://dspace.org/items/dc09de22-b774-4707-8cb4-e0bc1ec186c4DSpacehttp://dspace.org/items/dc09de22-b774-4707-8cb4-e0bc1ec186c4FernandesNatanaelCiência IDhttps://www.ciencia-id.pt2315-CC5A-3DBBORCIDhttp://orcid.org0000-0002-7737-9288PersonalDiogo, Duarte de MeloDSpacehttp://dspace.org/items/8525f1be-ff8f-4e46-b158-e59928e8a3e5DSpacehttp://dspace.org/items/8525f1be-ff8f-4e46-b158-e59928e8a3e5de Melo-DiogoDuarteCiência IDhttps://www.ciencia-id.pt9C10-9BD8-634EORCIDhttp://orcid.org0000-0001-9984-3603Scopus Author IDhttps://www.scopus.com56266511300PersonalFerreira, PaulaDSpacehttp://dspace.org/items/a7e98e57-6817-4cd2-95c5-42ebadda09c5DSpacehttp://dspace.org/items/a7e98e57-6817-4cd2-95c5-42ebadda09c5CalvinhoPaula Cristina Nunes FerreiraCiência IDhttps://www.ciencia-id.ptA119-FFB8-0899ORCIDhttp://orcid.org0000-0003-3393-4427Scopus Author IDhttps://www.scopus.com55321888200PersonalMoreira, André F.DSpacehttp://dspace.org/items/e20bf724-86f1-4fc8-800d-39ff19b624b1DSpacehttp://dspace.org/items/e20bf724-86f1-4fc8-800d-39ff19b624b1MoreiraAndré FerreiraCiência IDhttps://www.ciencia-id.pt4C1E-012B-83CEORCIDhttp://orcid.org0000-0002-0604-2506Scopus Author IDhttps://www.scopus.com56401521300PersonalCorreia, I.J.DSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adDSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adCorreiaIlídio Joaquim SobreiraCiência IDhttps://www.ciencia-id.ptF610-7373-DC81ORCIDhttp://orcid.org0000-0003-1613-9675Scopus Author IDhttps://www.scopus.com7003557499HostingInstitutionOrganizationaluBibliorume-mailmailto:noreplyuBibliorum@ubi.ptnoreplyuBibliorum@ubi.ptDOIIsPartOf10.1002/bit.279962025-01-03T01:30:20Z20212021-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.6/12573http://purl.org/coar/access_right/c_abf2open accessGelatinGold core silica shell nanoparticlesIR780PEG‐CH3Photodynamic therapyPhotothermal therapy5502654 bytesFundação para a Ciência e a TecnologiaBolsa de Doutoramento FCT: Development of multifunctional Gold Core Silica Shell nanomedicines for the immune/chemo/photothermal therapy of breast cancer [SFRH/BD/144680/2019]info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F144680%2F2019/PTSFRH/BD/144680/2019Bolsa de DoutoramentoCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaHealth Sciences Research Centre [UIDB/00709/2020]info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00709%2F2020/PTUIDB/00709/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://ubibliorum.ubi.pt/bitstreams/b547994e-bcbb-4267-90d4-7e092e82c5d3/downloadBiotechnology and Bioengineering1192644656EUA |
| spellingShingle | IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy Gonçalves, Ariana Gelatin Gold core silica shell nanoparticles IR780 PEG‐CH3 Photodynamic therapy Photothermal therapy |
| status | SINGLETON |
| subject.fl_str_mv | Gelatin Gold core silica shell nanoparticles IR780 PEG‐CH3 Photodynamic therapy Photothermal therapy |
| title | IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy |
| title_full | IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy |
| title_fullStr | IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy |
| title_full_unstemmed | IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy |
| title_short | IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy |
| title_sort | IR780 loaded gelatin‐PEG coated gold core silica shell nanorods for cancer‐targeted photothermal/photodynamic therapy |
| topic | Gelatin Gold core silica shell nanoparticles IR780 PEG‐CH3 Photodynamic therapy Photothermal therapy |
| topic_facet | Gelatin Gold core silica shell nanoparticles IR780 PEG‐CH3 Photodynamic therapy Photothermal therapy |
| url | http://hdl.handle.net/10400.6/12573 |
| visible | 1 |