Publication
Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin
| Summary: | Endophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed as an alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used in the production of IOLs and a fluoroquinolone used in endophthalmitis prophylaxis (moxifloxacin, MFX). Argon plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA) in the presence of MFX was the approach selected for surface modification, with MFX loaded both by entrapment in the grafted polyHEMA coating and by soaking. Surface and bulk properties were evaluated before and after surface modification and the MFX release profiles were obtained both in batch mode (sink conditions) and under hydrodynamic conditions, employing a purpose-built microfluidic cell, which simulated the hydrodynamic conditions around the eye lens. The effect of storage on the release profile of the best system was also assessed. The best system released MFX for ca. 15 days above the minimum inhibitory concentration for Staphylococcus aureus and Staphylococcus epidermidis. The released MFX showed antimicrobial activity against these bacteria and was non-cytotoxic against corneal endothelial cells. |
|---|---|
| Main Authors: | Vieira, Ana Paula |
| Other Authors: | Pimenta, Andreia; Silva, Diana; Gil, Maria; Alves, Patrícia; Coimbra, Patrícia; Mata, Jose; Bozukova, Dimitriya; Correia, Tiago R.; Correia, Ilídio Joaquim Sobreira; Serro, Ana Paula; Guiomar, António |
| Subject: | Cataract Endophthalmitis Intraocular lens Controlled release Moxifloxacin Plasma grafting Argon 2-hydroxyethyl methacrylate |
| Year: | 2017 |
| Country: | Portugal |
| Document type: | article |
| Access type: | restricted access |
| Associated institution: | Universidade da Beira Interior |
| Language: | English |
| Origin: | uBibliorum |
| _version_ | 1868420799907495936 |
|---|---|
| author | Vieira, Ana Paula |
| author2 | Pimenta, Andreia Silva, Diana Gil, Maria Alves, Patrícia Coimbra, Patrícia Mata, Jose Bozukova, Dimitriya Correia, Tiago R. Correia, Ilídio Joaquim Sobreira Serro, Ana Paula Guiomar, António |
| author2_role | author author author author author author author author author author author |
| author_facet | Vieira, Ana Paula Pimenta, Andreia Silva, Diana Gil, Maria Alves, Patrícia Coimbra, Patrícia Mata, Jose Bozukova, Dimitriya Correia, Tiago R. Correia, Ilídio Joaquim Sobreira Serro, Ana Paula Guiomar, António |
| author_role | author |
| contributor_name_str_mv | uBibliorum |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Vieira, Ana Paula\"},{\"Person.name\":\"Pimenta, Andreia\",\"Person.identifier.orcid\":\"0000-0002-9990-4581\"},{\"Person.name\":\"Silva, Diana\",\"Person.identifier.orcid\":\"0000-0003-0102-7048\"},{\"Person.name\":\"Gil, Maria\",\"Person.identifier.orcid\":\"0000-0003-0657-7751\"},{\"Person.name\":\"Alves, Patrícia\",\"Person.identifier.orcid\":\"0000-0002-8943-8329\"},{\"Person.name\":\"Coimbra, Patrícia\"},{\"Person.name\":\"Mata, Jose\",\"Person.identifier.orcid\":\"0000-0001-7021-407X\"},{\"Person.name\":\"Bozukova, Dimitriya\",\"Person.identifier.orcid\":\"0000-0001-5108-4556\"},{\"Person.name\":\"Correia, Tiago R.\",\"Person.identifier.orcid\":\"0000-0002-4077-4698\"},{\"Person.name\":\"Correia, Ilídio Joaquim Sobreira\",\"Person.identifier.orcid\":\"0000-0003-1613-9675\"},{\"Person.name\":\"Serro, Ana Paula\",\"Person.identifier.orcid\":\"0000-0002-6179-9296\"},{\"Person.name\":\"Guiomar, António\"}] |
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| datacite.creators.creator.creatorName.fl_str_mv | Vieira, Ana Paula Pimenta, Andreia Silva, Diana Gil, Maria Alves, Patrícia Coimbra, Patrícia Mata, Jose Bozukova, Dimitriya Correia, Tiago R. Correia, Ilídio Joaquim Sobreira Serro, Ana Paula Guiomar, António |
| datacite.date.Accepted.fl_str_mv | 2017-08-16T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-03-22T10:21:17Z |
| datacite.date.embargoed.fl_str_mv | 2018-03-22T10:21:17Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Cataract Endophthalmitis Intraocular lens Controlled release Moxifloxacin Plasma grafting Argon 2-hydroxyethyl methacrylate |
| datacite.titles.title.fl_str_mv | Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin |
| dc.contributor.none.fl_str_mv | uBibliorum |
| dc.creator.none.fl_str_mv | Vieira, Ana Paula Pimenta, Andreia Silva, Diana Gil, Maria Alves, Patrícia Coimbra, Patrícia Mata, Jose Bozukova, Dimitriya Correia, Tiago R. Correia, Ilídio Joaquim Sobreira Serro, Ana Paula Guiomar, António |
| dc.date.Accepted.fl_str_mv | 2017-08-16T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-03-22T10:21:17Z |
| dc.date.embargoed.fl_str_mv | 2018-03-22T10:21:17Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.6/4707 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Cataract Endophthalmitis Intraocular lens Controlled release Moxifloxacin Plasma grafting Argon 2-hydroxyethyl methacrylate |
| dc.title.fl_str_mv | Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Endophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed as an alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used in the production of IOLs and a fluoroquinolone used in endophthalmitis prophylaxis (moxifloxacin, MFX). Argon plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA) in the presence of MFX was the approach selected for surface modification, with MFX loaded both by entrapment in the grafted polyHEMA coating and by soaking. Surface and bulk properties were evaluated before and after surface modification and the MFX release profiles were obtained both in batch mode (sink conditions) and under hydrodynamic conditions, employing a purpose-built microfluidic cell, which simulated the hydrodynamic conditions around the eye lens. The effect of storage on the release profile of the best system was also assessed. The best system released MFX for ca. 15 days above the minimum inhibitory concentration for Staphylococcus aureus and Staphylococcus epidermidis. The released MFX showed antimicrobial activity against these bacteria and was non-cytotoxic against corneal endothelial cells. |
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| person_str_mv | Vieira, Ana Paula Pimenta, Andreia Pimenta, Andreia http://orcid.org/0000-0002-9990-4581 0000-0002-9990-4581 Silva, Diana Silva, Diana https://www.ciencia-id.pt/191C-D525-9EA5 191C-D525-9EA5 http://orcid.org/0000-0003-0102-7048 0000-0003-0102-7048 Gil, Maria Gil, Maria https://www.ciencia-id.pt/0E10-A6F7-901B 0E10-A6F7-901B http://orcid.org/0000-0003-0657-7751 0000-0003-0657-7751 Alves, Patrícia Alves, Patrícia https://www.ciencia-id.pt/341B-551C-19FD 341B-551C-19FD http://orcid.org/0000-0002-8943-8329 0000-0002-8943-8329 Coimbra, Patrícia Coimbra, Patrícia https://www.ciencia-id.pt/111E-0CE2-0C3E 111E-0CE2-0C3E Mata, Jose Mata, Jose https://www.ciencia-id.pt/7A15-7341-1FDC 7A15-7341-1FDC http://orcid.org/0000-0001-7021-407X 0000-0001-7021-407X Bozukova, Dimitriya Bozukova, Dimitriya http://orcid.org/0000-0001-5108-4556 0000-0001-5108-4556 Correia, Tiago R. Correia, Tiago R. https://www.ciencia-id.pt/491D-AA5E-FBC0 491D-AA5E-FBC0 http://orcid.org/0000-0002-4077-4698 0000-0002-4077-4698 Correia, Ilídio Joaquim Sobreira Correia, Ilídio Joaquim Sobreira https://www.ciencia-id.pt/F610-7373-DC81 F610-7373-DC81 http://orcid.org/0000-0003-1613-9675 0000-0003-1613-9675 Serro, Ana Paula Serro, Ana Paula https://www.ciencia-id.pt/C012-F8B6-A58E C012-F8B6-A58E http://orcid.org/0000-0002-6179-9296 0000-0002-6179-9296 Guiomar, António Guiomar, António https://www.ciencia-id.pt/9312-E34E-C90B 9312-E34E-C90B |
| publishDate | 2017 |
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| spelling | engElsevierpt_PTEndophthalmitis, an inflammation of the eye due to perioperative infection, may occur after cataract surgery. Intraocular lenses (IOLs) loaded with an antibiotic have been proposed as an alternative to the conventional postoperative endophthalmitis prophylaxis, since the antibiotic is delivered directly to the target site. In this work, an IOL-based antibiotic releasing system was prepared from a copolymer used in the production of IOLs and a fluoroquinolone used in endophthalmitis prophylaxis (moxifloxacin, MFX). Argon plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA) in the presence of MFX was the approach selected for surface modification, with MFX loaded both by entrapment in the grafted polyHEMA coating and by soaking. Surface and bulk properties were evaluated before and after surface modification and the MFX release profiles were obtained both in batch mode (sink conditions) and under hydrodynamic conditions, employing a purpose-built microfluidic cell, which simulated the hydrodynamic conditions around the eye lens. The effect of storage on the release profile of the best system was also assessed. The best system released MFX for ca. 15 days above the minimum inhibitory concentration for Staphylococcus aureus and Staphylococcus epidermidis. The released MFX showed antimicrobial activity against these bacteria and was non-cytotoxic against corneal endothelial cells.application/pdfpt_PTSurface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacinVieira, Ana PaulaPersonalPimenta, AndreiaDSpacehttp://dspace.org/items/a2c6dfdf-ce46-46f2-8a10-234061249edaDSpacehttp://dspace.org/items/a2c6dfdf-ce46-46f2-8a10-234061249edaPimentaAndreiaORCIDhttp://orcid.org0000-0002-9990-4581Scopus Author IDhttps://www.scopus.com57191821317PersonalSilva, DianaDSpacehttp://dspace.org/items/f83ebb9c-1d74-4e2d-bd3b-27782b08fb74DSpacehttp://dspace.org/items/f83ebb9c-1d74-4e2d-bd3b-27782b08fb74SilvaDianaCiência IDhttps://www.ciencia-id.pt191C-D525-9EA5ORCIDhttp://orcid.org0000-0003-0102-7048Researcher IDhttps://www.researcherid.comS-2076-2019Scopus Author IDhttps://www.scopus.com56789539900PersonalGil, MariaDSpacehttp://dspace.org/items/676a8017-743a-4f22-93be-4915428f318dDSpacehttp://dspace.org/items/676a8017-743a-4f22-93be-4915428f318dGilMaria HelenaCiência IDhttps://www.ciencia-id.pt0E10-A6F7-901BORCIDhttp://orcid.org0000-0003-0657-7751PersonalAlves, PatríciaDSpacehttp://dspace.org/items/64a3aef7-8d91-4327-8407-294909eed51aDSpacehttp://dspace.org/items/64a3aef7-8d91-4327-8407-294909eed51aAlvesPatríciaCiência IDhttps://www.ciencia-id.pt341B-551C-19FDORCIDhttp://orcid.org0000-0002-8943-8329Researcher IDhttps://www.researcherid.comI-1004-2013Scopus Author IDhttps://www.scopus.com12762379800PersonalCoimbra, PatríciaDSpacehttp://dspace.org/items/95a46930-ac14-449d-8ddd-db23927062b0DSpacehttp://dspace.org/items/95a46930-ac14-449d-8ddd-db23927062b0Almeida CoimbraPatrícia ManuelaCiência IDhttps://www.ciencia-id.pt111E-0CE2-0C3EPersonalMata, JoseDSpacehttp://dspace.org/items/15816376-3fd1-49f0-9809-8c25d09a79edDSpacehttp://dspace.org/items/15816376-3fd1-49f0-9809-8c25d09a79edMataJoseCiência IDhttps://www.ciencia-id.pt7A15-7341-1FDCORCIDhttp://orcid.org0000-0001-7021-407XScopus Author IDhttps://www.scopus.com25647116900PersonalBozukova, DimitriyaDSpacehttp://dspace.org/items/3a374faa-6f9e-49f2-b1bb-6af70e2cdeafDSpacehttp://dspace.org/items/3a374faa-6f9e-49f2-b1bb-6af70e2cdeafBozukovaDimitriyaORCIDhttp://orcid.org0000-0001-5108-4556PersonalCorreia, Tiago R.DSpacehttp://dspace.org/items/afa2836e-3210-4320-9c63-0b52828e043aDSpacehttp://dspace.org/items/afa2836e-3210-4320-9c63-0b52828e043aCorreiaTiago RuivoCiência IDhttps://www.ciencia-id.pt491D-AA5E-FBC0ORCIDhttp://orcid.org0000-0002-4077-4698Scopus Author IDhttps://www.scopus.com55670188900PersonalCorreia, Ilídio Joaquim SobreiraDSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adDSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adCorreiaIlídio Joaquim SobreiraCiência IDhttps://www.ciencia-id.ptF610-7373-DC81ORCIDhttp://orcid.org0000-0003-1613-9675Scopus Author IDhttps://www.scopus.com7003557499PersonalSerro, Ana PaulaDSpacehttp://dspace.org/items/02edea7c-61f6-4acd-9539-ac43ae44cfdfDSpacehttp://dspace.org/items/02edea7c-61f6-4acd-9539-ac43ae44cfdfSerroAna Paula Valagão Amadeu doCiência IDhttps://www.ciencia-id.ptC012-F8B6-A58EORCIDhttp://orcid.org0000-0002-6179-9296Scopus Author IDhttps://www.scopus.com6603259828PersonalGuiomar, AntónioDSpacehttp://dspace.org/items/3ef06c47-679e-4a84-9c65-25fa81ae6258DSpacehttp://dspace.org/items/3ef06c47-679e-4a84-9c65-25fa81ae6258Rebelo Ferreira GuiomarAntónio JorgeCiência IDhttps://www.ciencia-id.pt9312-E34E-C90BHostingInstitutionOrganizationaluBibliorume-mailmailto:noreplyuBibliorum@ubi.ptnoreplyuBibliorum@ubi.ptDOIIsPartOf10.1016/j.ejpb.2017.08.0062018-03-22T10:21:17Z2017-08-162017-08-16T00:00:00ZHandlehttp://hdl.handle.net/10400.6/4707http://purl.org/coar/access_right/c_16ecrestricted accessCataractEndophthalmitisIntraocular lensControlled releaseMoxifloxacinPlasma graftingArgon2-hydroxyethyl methacrylate1407848 bytesFundação para a Ciência e a TecnologiaSurfLenses: Surface modifications to control drug release from therapeutic ophthalmic lenses [M-ERA.NET/0005/2012]info:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0005%2F2012/PTM-ERA.NET/0005/20123599-PPCDTCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaSurface modifications to control drug release from therapeutic ophthalmic lenses [M-ERA.NET/0006/2012]info:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0006%2F2012/PTM-ERA.NET/0006/20123599-PPCDTCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaSterilization of clinically active hydrogels: looking for efficient strategies [PTDC/CTM-BIO/3640/2014]info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCTM-BIO%2F3640%2F2014/PTPTDC/CTM-BIO/3640/20143599-PPCDTCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaStrategic Project - UI 100 - 2013-2014 [PEst-OE/QUI/UI0100/2013]info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FQUI%2FUI0100%2F2013/PTPEst-OE/QUI/UI0100/20136817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaHealth Sciences Research Centre [UID/Multi/00709/2013]info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PTUID/Multi/00709/20136817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaDevelopment of New Stimuli-Responsive Polymer-Liposome Complexes by Living Radical Polymerization and “Click Chemistry” [SFRH/BPD/69410/2010]info:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F69410%2F2010/PTSFRH/BPD/69410/2010Crossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaBolsa de Pós-Doutoramento FCT: Utilização de enxertos de osso alógeno e materiais derivados do seu processamento na preparação de sistemas de libertação controlada e localizada de antibióticos para aplicações em cirurgia ortopédica [SFRH/BPD/73367/2010]info:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBPD%2F73367%2F2010/PTSFRH/BPD/73367/2010FARHBolsa de Pós-DoutoramentoCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://ubibliorum.ubi.pt/bitstreams/c799f828-81c7-4633-9567-b119fb704b20/downloadEuropean Journal of Pharmaceutics and Biopharmaceutics1205262 |
| spellingShingle | Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin Vieira, Ana Paula Cataract Endophthalmitis Intraocular lens Controlled release Moxifloxacin Plasma grafting Argon 2-hydroxyethyl methacrylate |
| status | SINGLETON |
| subject.fl_str_mv | Cataract Endophthalmitis Intraocular lens Controlled release Moxifloxacin Plasma grafting Argon 2-hydroxyethyl methacrylate |
| title | Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin |
| title_full | Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin |
| title_fullStr | Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin |
| title_full_unstemmed | Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin |
| title_short | Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin |
| title_sort | Surface modification of an intraocular lens material by plasma-assisted grafting with 2-hydroxyethyl methacrylate (HEMA), for controlled release of moxifloxacin |
| topic | Cataract Endophthalmitis Intraocular lens Controlled release Moxifloxacin Plasma grafting Argon 2-hydroxyethyl methacrylate |
| topic_facet | Cataract Endophthalmitis Intraocular lens Controlled release Moxifloxacin Plasma grafting Argon 2-hydroxyethyl methacrylate |
| url | http://hdl.handle.net/10400.6/4707 |
| visible | 1 |