Publicação
Photocurable Polymeric Blends for Surgical Application
| Resumo: | The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives. |
|---|---|
| Autores principais: | Cernadas, Teresa |
| Outros Autores: | Santos, Marta; Miguel, Sónia P.; Correia, I.J.; Alves, Patrícia; Ferreira, Paula |
| Assunto: | Photocuring Polymeric blends Bioadhesive Biocompatibility Antibacterial activity |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade da Beira Interior |
| Idioma: | inglês |
| Origem: | uBibliorum |
| _version_ | 1868420922046676992 |
|---|---|
| author | Cernadas, Teresa |
| author2 | Santos, Marta Miguel, Sónia P. Correia, I.J. Alves, Patrícia Ferreira, Paula |
| author2_role | author author author author author |
| author_facet | Cernadas, Teresa Santos, Marta Miguel, Sónia P. Correia, I.J. Alves, Patrícia Ferreira, Paula |
| author_role | author |
| contributor_name_str_mv | uBibliorum |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Cernadas, Teresa\",\"Person.identifier.orcid\":\"0000-0003-2704-7290\"},{\"Person.name\":\"Santos, Marta\",\"Person.identifier.orcid\":\"0000-0002-1079-3070\"},{\"Person.name\":\"Miguel, Sónia P.\",\"Person.identifier.orcid\":\"0000-0001-7274-0399\"},{\"Person.name\":\"Correia, I.J.\",\"Person.identifier.orcid\":\"0000-0003-1613-9675\"},{\"Person.name\":\"Alves, Patrícia\",\"Person.identifier.orcid\":\"0000-0002-8943-8329\"},{\"Person.name\":\"Ferreira, Paula\",\"Person.identifier.orcid\":\"0000-0003-3393-4427\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | uBibliorum |
| datacite.creators.creator.creatorName.fl_str_mv | Cernadas, Teresa Santos, Marta Miguel, Sónia P. Correia, I.J. Alves, Patrícia Ferreira, Paula |
| datacite.date.Accepted.fl_str_mv | 2020-12-12T00:00:00Z |
| datacite.date.available.fl_str_mv | 2021-01-21T17:00:06Z |
| datacite.date.embargoed.fl_str_mv | 2021-01-21T17:00:06Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Photocuring Polymeric blends Bioadhesive Biocompatibility Antibacterial activity |
| datacite.titles.title.fl_str_mv | Photocurable Polymeric Blends for Surgical Application |
| dc.contributor.none.fl_str_mv | uBibliorum |
| dc.creator.none.fl_str_mv | Cernadas, Teresa Santos, Marta Miguel, Sónia P. Correia, I.J. Alves, Patrícia Ferreira, Paula |
| dc.date.Accepted.fl_str_mv | 2020-12-12T00:00:00Z |
| dc.date.available.fl_str_mv | 2021-01-21T17:00:06Z |
| dc.date.embargoed.fl_str_mv | 2021-01-21T17:00:06Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.6/11050 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Photocuring Polymeric blends Bioadhesive Biocompatibility Antibacterial activity |
| dc.title.fl_str_mv | Photocurable Polymeric Blends for Surgical Application |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://ubibliorum.ubi.pt/bitstreams/c42018d9-5bd6-46ed-bd07-400b72938dcd/download |
| funding.funder.alternateName_str_mv | FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.identifier_str_mv | RECI/QEQ-QFI/0168/2012 UID/QUI/00313/2019 |
| funding.name_str_mv | COMPETE 6817 - DCRRNI ID |
| funding_str_mv | RECI/QEQ-QFI/0168/2012 info:eu-repo/grantAgreement/FCT/COMPETE/RECI%2FQEQ-QFI%2F0168%2F2012/PT UID/QUI/00313/2019 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00313%2F2019/PT |
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| identifier.url.fl_str_mv | http://hdl.handle.net/10400.6/11050 |
| instacron_str | ubi |
| institution | Universidade da Beira Interior |
| instname_str | Universidade da Beira Interior |
| language | eng |
| network_acronym_str | ubibliorum |
| network_name_str | uBibliorum |
| oai_identifier_str | oai:ubibliorum.ubi.pt:10400.6/11050 |
| organization_str_mv | urn:organizationAcronym:ubi |
| person_str_mv | Cernadas, Teresa Cernadas, Teresa https://www.ciencia-id.pt/8C1C-0ED0-BDA6 8C1C-0ED0-BDA6 http://orcid.org/0000-0003-2704-7290 0000-0003-2704-7290 Santos, Marta Santos, Marta https://www.ciencia-id.pt/9615-4D56-1273 9615-4D56-1273 http://orcid.org/0000-0002-1079-3070 0000-0002-1079-3070 Miguel, Sónia P. Miguel, Sónia P. https://www.ciencia-id.pt/1A13-ABC0-C32C 1A13-ABC0-C32C http://orcid.org/0000-0001-7274-0399 0000-0001-7274-0399 Correia, I.J. Correia, I.J. https://www.ciencia-id.pt/F610-7373-DC81 F610-7373-DC81 http://orcid.org/0000-0003-1613-9675 0000-0003-1613-9675 Alves, Patrícia Alves, Patrícia https://www.ciencia-id.pt/341B-551C-19FD 341B-551C-19FD http://orcid.org/0000-0002-8943-8329 0000-0002-8943-8329 Ferreira, Paula Ferreira, Paula https://www.ciencia-id.pt/A119-FFB8-0899 A119-FFB8-0899 http://orcid.org/0000-0003-3393-4427 0000-0003-3393-4427 |
| publishDate | 2020 |
| publisher.none.fl_str_mv | MDPI |
| reponame_str | uBibliorum |
| repository_id_str | urn:repositoryAcronym:ubibliorum |
| service_str_mv | urn:repositoryAcronym:ubibliorum |
| spelling | engMDPIpt_PTThe preparation of photocrosslinkable bioadhesives synthesized from oligomers of lactic acid and polycaprolactone (PCL), both functionalized with 2-isocyanoethyl acrylate (AOI), were studied. The obtained modified macromers of LA-AOI (mLA) and PCL-AOI (mCL) were chemically characterized by 1H NMR and used to formulate polymeric blends with different mass proportions, 1:1, 1:2 and 2:1, respectively. Subsequently, the produced blends were crosslinked, considering two UV irradiation times: 30 and 120 s. After their production, the thermal and mechanical properties of bioadhesives were assessed, where upon the rheology, gel content, hydrolytic degradation and dynamic contact angles were determined. Furthermore, the cytotoxic profile of bioadhesives was evaluated in contact with human dermal fibroblasts cells, whereas their antibacterial effect was studied monitoring Escherichia coli and S. aureus growth. Overall, flexible and resistant films were obtained, presenting promising features to be used as surgical bioadhesives.application/pdfpt_PTPhotocurable Polymeric Blends for Surgical ApplicationPersonalCernadas, TeresaDSpacehttp://dspace.org/items/8c8f1b33-1419-4282-ba83-68e6e8f80805DSpacehttp://dspace.org/items/8c8f1b33-1419-4282-ba83-68e6e8f80805CernadasMaria TeresaCiência IDhttps://www.ciencia-id.pt8C1C-0ED0-BDA6ORCIDhttp://orcid.org0000-0003-2704-7290PersonalSantos, MartaDSpacehttp://dspace.org/items/09ab8e77-653c-4073-9e51-0eda1c2aa4d9DSpacehttp://dspace.org/items/09ab8e77-653c-4073-9e51-0eda1c2aa4d9SantosMartaCiência IDhttps://www.ciencia-id.pt9615-4D56-1273ORCIDhttp://orcid.org0000-0002-1079-3070Scopus Author IDhttps://www.scopus.com57207052926PersonalMiguel, Sónia P.DSpacehttp://dspace.org/items/3956033a-4abf-439b-a4fd-25c5bd9d8e7aDSpacehttp://dspace.org/items/3956033a-4abf-439b-a4fd-25c5bd9d8e7aPereira MiguelSónia AlexandraCiência IDhttps://www.ciencia-id.pt1A13-ABC0-C32CORCIDhttp://orcid.org0000-0001-7274-0399Scopus Author IDhttps://www.scopus.com55638166400PersonalCorreia, I.J.DSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adDSpacehttp://dspace.org/items/f2c3e779-34a2-4309-950a-80687664c6adCorreiaIlídio Joaquim SobreiraCiência IDhttps://www.ciencia-id.ptF610-7373-DC81ORCIDhttp://orcid.org0000-0003-1613-9675Scopus Author IDhttps://www.scopus.com7003557499PersonalAlves, PatríciaDSpacehttp://dspace.org/items/64a3aef7-8d91-4327-8407-294909eed51aDSpacehttp://dspace.org/items/64a3aef7-8d91-4327-8407-294909eed51aAlvesPatríciaCiência IDhttps://www.ciencia-id.pt341B-551C-19FDORCIDhttp://orcid.org0000-0002-8943-8329Researcher IDhttps://www.researcherid.comI-1004-2013Scopus Author IDhttps://www.scopus.com12762379800PersonalFerreira, PaulaDSpacehttp://dspace.org/items/a7e98e57-6817-4cd2-95c5-42ebadda09c5DSpacehttp://dspace.org/items/a7e98e57-6817-4cd2-95c5-42ebadda09c5CalvinhoPaula Cristina Nunes FerreiraCiência IDhttps://www.ciencia-id.ptA119-FFB8-0899ORCIDhttp://orcid.org0000-0003-3393-4427Scopus Author IDhttps://www.scopus.com55321888200HostingInstitutionOrganizationaluBibliorume-mailmailto:noreplyuBibliorum@ubi.ptnoreplyuBibliorum@ubi.ptDOIIsPartOf10.3390/ma132456812021-01-21T17:00:06Z2020-12-122020-12-12T00:00:00ZHandlehttp://hdl.handle.net/10400.6/11050http://purl.org/coar/access_right/c_abf2open accessPhotocuringPolymeric blendsBioadhesiveBiocompatibilityAntibacterial activity6448942 bytesFundação para a Ciência e a TecnologiaUC-NMR: uma viagem do espaço químico à função biológica [RECI/QEQ-QFI/0168/2012]info:eu-repo/grantAgreement/FCT/COMPETE/RECI%2FQEQ-QFI%2F0168%2F2012/PTRECI/QEQ-QFI/0168/2012COMPETECrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaCQC: Coimbra Chemistry Center [UID/QUI/00313/2019]info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FQUI%2F00313%2F2019/PTUID/QUI/00313/20196817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2020-12-12http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://ubibliorum.ubi.pt/bitstreams/c42018d9-5bd6-46ed-bd07-400b72938dcd/downloadMaterials13245681Swiss |
| spellingShingle | Photocurable Polymeric Blends for Surgical Application Cernadas, Teresa Photocuring Polymeric blends Bioadhesive Biocompatibility Antibacterial activity |
| status | SINGLETON |
| subject.fl_str_mv | Photocuring Polymeric blends Bioadhesive Biocompatibility Antibacterial activity |
| title | Photocurable Polymeric Blends for Surgical Application |
| title_full | Photocurable Polymeric Blends for Surgical Application |
| title_fullStr | Photocurable Polymeric Blends for Surgical Application |
| title_full_unstemmed | Photocurable Polymeric Blends for Surgical Application |
| title_short | Photocurable Polymeric Blends for Surgical Application |
| title_sort | Photocurable Polymeric Blends for Surgical Application |
| topic | Photocuring Polymeric blends Bioadhesive Biocompatibility Antibacterial activity |
| topic_facet | Photocuring Polymeric blends Bioadhesive Biocompatibility Antibacterial activity |
| url | http://hdl.handle.net/10400.6/11050 |
| visible | 1 |