Publicação
Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial
| Resumo: | Introduction: Kidney transplant (KT) recipients are highly susceptible to urinary tract infections (UTIs). Few data are available regarding the effects of cranberry products in KT recipients. Subjects and methods: This was a randomized double-blind study comparing daily treatment with a cranberry capsule versus a placebo capsule for 6 months. The study protocol was conducted in accordance with the Helsinki Declaration and was approved by the local ethics committee. The study group comprised women undergoing KT for over 1 year, and the exclusion criteria included simultaneous antibiotic UTI prophylaxis. The primary endpoint was UTI occurrence, and the secondary endpoints were the time to first UTI, hospitalization, antibiotic resistance, graft function, immunosuppressive dose changes, and side effects. Results: 55 KT women at a single centre were included as follows: 25 were randomized to the cranberry group, and 30 were assigned to the placebo group. During the study period, 16.4% of the participants presented with a UTI. A diagnosis of UTI within the previous year and KT duration, but not cranberry use (p=0.95) were independent predictors of UTI. Discussion: Cranberry capsules appear to be safe in KT women; however, no clinical efficacy of UTI prophylaxis was demonstrated in this well-designed but underpowered study. Further multicentric and longer trial should be performed to determine cranberry clinical efficacy |
|---|---|
| Autores principais: | Pereira,Tiago Assis |
| Outros Autores: | Fernandes,Ana Raquel; Mendes,Artur; Oliveira,Regina; Casqueiro,Ana; Birne,Rita; Matias,Patrícia; Jorge,Cristina; Adragão,Teresa; Bruges,Margarida; Toscano,Cristina; Laranjeira,Tânia; Mirco,Ana; Falcão,Fátima; Machado,Domingos; Weigert,André |
| Assunto: | Cranberry Prophylaxis Kidney Transplantation Urinary Tract Infection Vaccinium macrocarpon |
| Ano: | 2017 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Fundação para a Ciência e Tecnologia |
| Idioma: | inglês |
| Origem: | SciELO Portugal |
| _version_ | 1877792003199074304 |
|---|---|
| author | Pereira,Tiago Assis |
| author2 | Fernandes,Ana Raquel Mendes,Artur Oliveira,Regina Casqueiro,Ana Birne,Rita Matias,Patrícia Jorge,Cristina Adragão,Teresa Bruges,Margarida Toscano,Cristina Laranjeira,Tânia Mirco,Ana Falcão,Fátima Machado,Domingos Weigert,André |
| author2_role | author author author author author author author author author author author author author author author |
| author_facet | Pereira,Tiago Assis Fernandes,Ana Raquel Mendes,Artur Oliveira,Regina Casqueiro,Ana Birne,Rita Matias,Patrícia Jorge,Cristina Adragão,Teresa Bruges,Margarida Toscano,Cristina Laranjeira,Tânia Mirco,Ana Falcão,Fátima Machado,Domingos Weigert,André |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Pereira,Tiago Assis\"},{\"Person.name\":\"Fernandes,Ana Raquel\"},{\"Person.name\":\"Mendes,Artur\"},{\"Person.name\":\"Oliveira,Regina\"},{\"Person.name\":\"Casqueiro,Ana\"},{\"Person.name\":\"Birne,Rita\"},{\"Person.name\":\"Matias,Patrícia\"},{\"Person.name\":\"Jorge,Cristina\"},{\"Person.name\":\"Adragão,Teresa\"},{\"Person.name\":\"Bruges,Margarida\"},{\"Person.name\":\"Toscano,Cristina\"},{\"Person.name\":\"Laranjeira,Tânia\"},{\"Person.name\":\"Mirco,Ana\"},{\"Person.name\":\"Falcão,Fátima\"},{\"Person.name\":\"Machado,Domingos\"},{\"Person.name\":\"Weigert,André\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Pereira,Tiago Assis Fernandes,Ana Raquel Mendes,Artur Oliveira,Regina Casqueiro,Ana Birne,Rita Matias,Patrícia Jorge,Cristina Adragão,Teresa Bruges,Margarida Toscano,Cristina Laranjeira,Tânia Mirco,Ana Falcão,Fátima Machado,Domingos Weigert,André |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Cranberry Prophylaxis Kidney Transplantation Urinary Tract Infection Vaccinium macrocarpon |
| datacite.titles.title.fl_str_mv | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial |
| dc.creator.none.fl_str_mv | Pereira,Tiago Assis Fernandes,Ana Raquel Mendes,Artur Oliveira,Regina Casqueiro,Ana Birne,Rita Matias,Patrícia Jorge,Cristina Adragão,Teresa Bruges,Margarida Toscano,Cristina Laranjeira,Tânia Mirco,Ana Falcão,Fátima Machado,Domingos Weigert,André |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100001 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Portuguese Journal of Nephrology & Hypertension v.31 n.1 2017 |
| dc.subject.none.fl_str_mv | Cranberry Prophylaxis Kidney Transplantation Urinary Tract Infection Vaccinium macrocarpon |
| dc.title.fl_str_mv | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Introduction: Kidney transplant (KT) recipients are highly susceptible to urinary tract infections (UTIs). Few data are available regarding the effects of cranberry products in KT recipients. Subjects and methods: This was a randomized double-blind study comparing daily treatment with a cranberry capsule versus a placebo capsule for 6 months. The study protocol was conducted in accordance with the Helsinki Declaration and was approved by the local ethics committee. The study group comprised women undergoing KT for over 1 year, and the exclusion criteria included simultaneous antibiotic UTI prophylaxis. The primary endpoint was UTI occurrence, and the secondary endpoints were the time to first UTI, hospitalization, antibiotic resistance, graft function, immunosuppressive dose changes, and side effects. Results: 55 KT women at a single centre were included as follows: 25 were randomized to the cranberry group, and 30 were assigned to the placebo group. During the study period, 16.4% of the participants presented with a UTI. A diagnosis of UTI within the previous year and KT duration, but not cranberry use (p=0.95) were independent predictors of UTI. Discussion: Cranberry capsules appear to be safe in KT women; however, no clinical efficacy of UTI prophylaxis was demonstrated in this well-designed but underpowered study. Further multicentric and longer trial should be performed to determine cranberry clinical efficacy |
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| language | eng |
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| person_str_mv | Pereira,Tiago Assis Fernandes,Ana Raquel Mendes,Artur Oliveira,Regina Casqueiro,Ana Birne,Rita Matias,Patrícia Jorge,Cristina Adragão,Teresa Bruges,Margarida Toscano,Cristina Laranjeira,Tânia Mirco,Ana Falcão,Fátima Machado,Domingos Weigert,André |
| publishDate | 2017 |
| publisher.none.fl_str_mv | Sociedade Portuguesa de Nefrologia |
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| spelling | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trialPereira,Tiago AssisFernandes,Ana RaquelMendes,ArturOliveira,ReginaCasqueiro,AnaBirne,RitaMatias,PatríciaJorge,CristinaAdragão,TeresaBruges,MargaridaToscano,CristinaLaranjeira,TâniaMirco,AnaFalcão,FátimaMachado,DomingosWeigert,AndréCranberryProphylaxisKidney TransplantationUrinary Tract InfectionVaccinium macrocarponopen accesshttp://purl.org/coar/access_right/c_abf2http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100001URLhttp://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100001URLHasVersion2017-03-01Introduction: Kidney transplant (KT) recipients are highly susceptible to urinary tract infections (UTIs). Few data are available regarding the effects of cranberry products in KT recipients. Subjects and methods: This was a randomized double-blind study comparing daily treatment with a cranberry capsule versus a placebo capsule for 6 months. The study protocol was conducted in accordance with the Helsinki Declaration and was approved by the local ethics committee. The study group comprised women undergoing KT for over 1 year, and the exclusion criteria included simultaneous antibiotic UTI prophylaxis. The primary endpoint was UTI occurrence, and the secondary endpoints were the time to first UTI, hospitalization, antibiotic resistance, graft function, immunosuppressive dose changes, and side effects. Results: 55 KT women at a single centre were included as follows: 25 were randomized to the cranberry group, and 30 were assigned to the placebo group. During the study period, 16.4% of the participants presented with a UTI. A diagnosis of UTI within the previous year and KT duration, but not cranberry use (p=0.95) were independent predictors of UTI. Discussion: Cranberry capsules appear to be safe in KT women; however, no clinical efficacy of UTI prophylaxis was demonstrated in this well-designed but underpowered study. Further multicentric and longer trial should be performed to determine cranberry clinical efficacySociedade Portuguesa de NefrologiaPortuguese Journal of Nephrology & Hypertension v.31 n.1 2017text/htmlengjournal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial Pereira,Tiago Assis Cranberry Prophylaxis Kidney Transplantation Urinary Tract Infection Vaccinium macrocarpon |
| status | SINGLETON |
| subject.fl_str_mv | Cranberry Prophylaxis Kidney Transplantation Urinary Tract Infection Vaccinium macrocarpon |
| title | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial |
| title_full | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial |
| title_fullStr | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial |
| title_full_unstemmed | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial |
| title_short | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial |
| title_sort | Are cranberry capsules effective and safe in preventing urinary tract infections in kidney transplantation? A randomized pilot clinical trial |
| topic | Cranberry Prophylaxis Kidney Transplantation Urinary Tract Infection Vaccinium macrocarpon |
| topic_facet | Cranberry Prophylaxis Kidney Transplantation Urinary Tract Infection Vaccinium macrocarpon |
| url | http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692017000100001 |
| visible | 1 |
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