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Cortisol and parathyroid hormone-related peptide are reciprocally modulated by negative feedback

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Resumo:In previous in vitro studies, we have shown that the N-terminal region of parathyroid hormone-related protein (PTHrP) can stimulate cortisol production in sea bream, Sparus auratus, interrenal tissue, possibly through a paracrine action. In the current study, the systemic interaction between cortisol and PTHrP was studied in vivo. Sustained elevated blood cortisol levels, induced either by cortisol injection or conWnement stress, suppressed circulating PTHrP 6 and 24-fold,respectively, by comparison to control Wsh.reduced cortisol levels, prevented the decrease of plasma PTHrP observed in conWned Wsh and raised plasma PTHrPrespectively, by comparison to control fish.
Autores principais:Guerreiro, P. M.
Outros Autores:Rotllant, J.; Fuentes, J.; Power, Deborah; Canario, Adelino V. M.
Assunto:Parathyroid hormone-related peptide Cortisol Negative feedback Sea bream Sparus
Ano:2006
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Algarve
Idioma:inglês
Origem:Sapientia - Universidade do Algarve

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