Publicação
Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae
| Resumo: | The effects of an N-terminal peptide (amino acids 1-38) of Fugu parathyroid hormone-related protein (PTHrP 1-38) on calcium regulation of larval sea bream were investigated in seawater (36 per thousand) and after transfer to dilute seawater (12 per thousand). Exposure to PTHrP 1-38 evoked a 1.5-fold increase in calcium influx in both full-strength and dilute seawater. Calcium influx in dilute seawater-adapted larvae was roughly one-half that observed in full-strength seawater controls. PTHrP 1-38 also reduced drinking of fish in seawater but, at all concentrations tested, was without effect in dilute seawater. The amount of water imbibed was 55% lower in dilute seawater than in seawater. PTHrP 1-38 exposure affected the calcium influx route: the main contribution of calcium uptake shifted from intestinal absorption to extraintestinal uptake, probably by the induction of a dose-dependent increase in branchial (active) transport. Moreover, seawater-adapted fish exposed to 1 nM and 10 mM PTHrP 1-38 experienced a 2.5-fold reduction in overall calcium efflux. Overall, the calciotropic action of PTHrP 1-38 resulted in a dose-dependent increase in net calcium balance. |
|---|---|
| Autores principais: | Guerreiro, P. M. |
| Outros Autores: | Fuentes, T.; Power, Deborah; Ingleton, P. M.; Flik, G.; Canario, Adelino V. M. |
| Assunto: | Hormone N-terminal Calcium regulation |
| Ano: | 2001 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso restrito |
| Instituição associada: | Universidade do Algarve |
| Idioma: | inglês |
| Origem: | Sapientia - Universidade do Algarve |
| _version_ | 1877785469226319872 |
|---|---|
| author | Guerreiro, P. M. |
| author2 | Fuentes, T. Power, Deborah Ingleton, P. M. Flik, G. Canario, Adelino V. M. |
| author2_role | author author author author author |
| author_facet | Guerreiro, P. M. Fuentes, T. Power, Deborah Ingleton, P. M. Flik, G. Canario, Adelino V. M. |
| author_role | author |
| contributor_name_str_mv | Sapientia |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Guerreiro, P. M.\",\"Person.identifier.cienciaID\":\"5C13-965D-3148\",\"Person.identifier.orcid\":\"0000-0001-5371-7919\"},{\"Person.name\":\"Fuentes, T.\"},{\"Person.name\":\"Power, Deborah\",\"Person.identifier.cienciaID\":\"891A-8A44-3CAE\",\"Person.identifier.orcid\":\"0000-0003-1366-0246\",\"Person.identifier.scopusAuthorID\":\"7101806760\"},{\"Person.name\":\"Ingleton, P. M.\"},{\"Person.name\":\"Flik, G.\"},{\"Person.name\":\"Canario, Adelino V. M.\",\"Person.identifier.cienciaID\":\"1F1E-D3B3-F804\",\"Person.identifier.orcid\":\"0000-0002-6244-6468\",\"Person.identifier.researcherID\":\"C-7942-2009\",\"Person.identifier.scopusAuthorID\":\"56568523700\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Sapientia |
| datacite.creators.creator.creatorName.fl_str_mv | Guerreiro, P. M. Fuentes, T. Power, Deborah Ingleton, P. M. Flik, G. Canario, Adelino V. M. |
| datacite.date.Accepted.fl_str_mv | 2001-09-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2014-05-17T10:10:56Z |
| datacite.date.embargoed.fl_str_mv | 2014-05-17T10:10:56Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| datacite.subjects.subject.fl_str_mv | Hormone N-terminal Calcium regulation |
| datacite.titles.title.fl_str_mv | Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae |
| dc.contributor.none.fl_str_mv | Sapientia |
| dc.creator.none.fl_str_mv | Guerreiro, P. M. Fuentes, T. Power, Deborah Ingleton, P. M. Flik, G. Canario, Adelino V. M. |
| dc.date.Accepted.fl_str_mv | 2001-09-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2014-05-17T10:10:56Z |
| dc.date.embargoed.fl_str_mv | 2014-05-17T10:10:56Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.1/3992 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | American Physiological Society |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_16ec |
| dc.subject.none.fl_str_mv | Hormone N-terminal Calcium regulation |
| dc.title.fl_str_mv | Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The effects of an N-terminal peptide (amino acids 1-38) of Fugu parathyroid hormone-related protein (PTHrP 1-38) on calcium regulation of larval sea bream were investigated in seawater (36 per thousand) and after transfer to dilute seawater (12 per thousand). Exposure to PTHrP 1-38 evoked a 1.5-fold increase in calcium influx in both full-strength and dilute seawater. Calcium influx in dilute seawater-adapted larvae was roughly one-half that observed in full-strength seawater controls. PTHrP 1-38 also reduced drinking of fish in seawater but, at all concentrations tested, was without effect in dilute seawater. The amount of water imbibed was 55% lower in dilute seawater than in seawater. PTHrP 1-38 exposure affected the calcium influx route: the main contribution of calcium uptake shifted from intestinal absorption to extraintestinal uptake, probably by the induction of a dose-dependent increase in branchial (active) transport. Moreover, seawater-adapted fish exposed to 1 nM and 10 mM PTHrP 1-38 experienced a 2.5-fold reduction in overall calcium efflux. Overall, the calciotropic action of PTHrP 1-38 resulted in a dose-dependent increase in net calcium balance. |
| dirty | 0 |
| eu_rights_str_mv | restrictedAccess |
| format | article |
| fulltext.url.fl_str_mv | https://sapientia.ualg.pt/bitstreams/6bfbcf13-0eda-45bc-bcf3-a82cc5d907e5/download |
| id | sapientia_0039130ee02f48ed105e9fc90db1142f |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.1/3992 |
| inst_facet_str | urn:organizationAcronym:ualg{{{_:::_}}}Universidade do Algarve |
| instacron_str | ualg |
| institution | Universidade do Algarve |
| instname_str | Universidade do Algarve |
| language | eng |
| network_acronym_str | sapientia |
| network_name_str | Sapientia - Universidade do Algarve |
| oai_identifier_str | oai:sapientia.ualg.pt:10400.1/3992 |
| organization_str_mv | urn:organizationAcronym:ualg |
| person_str_mv | Guerreiro, P. M. Guerreiro, P. M. https://www.ciencia-id.pt/5C13-965D-3148 5C13-965D-3148 http://orcid.org/0000-0001-5371-7919 0000-0001-5371-7919 Fuentes, T. Power, Deborah Power, Deborah https://www.ciencia-id.pt/891A-8A44-3CAE 891A-8A44-3CAE http://orcid.org/0000-0003-1366-0246 0000-0003-1366-0246 Ingleton, P. M. Flik, G. Canario, Adelino V. M. Canario, Adelino V. M. https://www.ciencia-id.pt/1F1E-D3B3-F804 1F1E-D3B3-F804 http://orcid.org/0000-0002-6244-6468 0000-0002-6244-6468 |
| publishDate | 2001 |
| publisher.none.fl_str_mv | American Physiological Society |
| repo_facet_str | urn:repositoryAcronym:sapientia{{{_:::_}}}Sapientia - Universidade do Algarve |
| reponame_str | Sapientia - Universidade do Algarve |
| repository_id_str | urn:repositoryAcronym:sapientia |
| service_str_mv | urn:repositoryAcronym:sapientia |
| spelling | engAmerican Physiological SocietyporThe effects of an N-terminal peptide (amino acids 1-38) of Fugu parathyroid hormone-related protein (PTHrP 1-38) on calcium regulation of larval sea bream were investigated in seawater (36 per thousand) and after transfer to dilute seawater (12 per thousand). Exposure to PTHrP 1-38 evoked a 1.5-fold increase in calcium influx in both full-strength and dilute seawater. Calcium influx in dilute seawater-adapted larvae was roughly one-half that observed in full-strength seawater controls. PTHrP 1-38 also reduced drinking of fish in seawater but, at all concentrations tested, was without effect in dilute seawater. The amount of water imbibed was 55% lower in dilute seawater than in seawater. PTHrP 1-38 exposure affected the calcium influx route: the main contribution of calcium uptake shifted from intestinal absorption to extraintestinal uptake, probably by the induction of a dose-dependent increase in branchial (active) transport. Moreover, seawater-adapted fish exposed to 1 nM and 10 mM PTHrP 1-38 experienced a 2.5-fold reduction in overall calcium efflux. Overall, the calciotropic action of PTHrP 1-38 resulted in a dose-dependent increase in net calcium balance.application/pdfporParathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvaePersonalGuerreiro, P. M.DSpacehttp://dspace.org/items/d0a8a148-98e7-4899-8fb0-0b8afa91e4a4DSpacehttp://dspace.org/items/d0a8a148-98e7-4899-8fb0-0b8afa91e4a4GuerreiroPedro MiguelCiência IDhttps://www.ciencia-id.pt5C13-965D-3148ORCIDhttp://orcid.org0000-0001-5371-7919Fuentes, T.PersonalPower, DeborahDSpacehttp://dspace.org/items/c68f5ffb-63f6-4c70-8957-29e464fb59c0DSpacehttp://dspace.org/items/c68f5ffb-63f6-4c70-8957-29e464fb59c0PowerDeborah MaryCiência IDhttps://www.ciencia-id.pt891A-8A44-3CAEORCIDhttp://orcid.org0000-0003-1366-0246Scopus Author IDhttps://www.scopus.com7101806760Ingleton, P. M.Flik, G.PersonalCanario, Adelino V. M.DSpacehttp://dspace.org/items/5f6e51ee-9113-469e-8b9e-f30f2d452521DSpacehttp://dspace.org/items/5f6e51ee-9113-469e-8b9e-f30f2d452521CanarioAdelinoCiência IDhttps://www.ciencia-id.pt1F1E-D3B3-F804ORCIDhttp://orcid.org0000-0002-6244-6468Researcher IDhttps://www.researcherid.comC-7942-2009Scopus Author IDhttps://www.scopus.com56568523700HostingInstitutionOrganizationalSapientiae-mailmailto:repositorio@ualg.ptrepositorio@ualg.ptISSNIsPartOf0363-6119URNIsPartOfAUT: ACA00258; DPO00386;2014-05-17T10:10:56Z2001-092014-05-13T10:29:51Z2001-09-01T00:00:00ZHandlehttp://hdl.handle.net/10400.1/3992http://purl.org/coar/access_right/c_16ecrestricted accessHormoneN-terminalCalcium regulation130219 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_16ecapplication/pdffulltexthttps://sapientia.ualg.pt/bitstreams/6bfbcf13-0eda-45bc-bcf3-a82cc5d907e5/downloadAmerican Journal of Physiology - Regulatory, Integrative and Comparative Physiology2813855860 |
| spellingShingle | Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae Guerreiro, P. M. Hormone N-terminal Calcium regulation |
| status | SINGLETON |
| subject.fl_str_mv | Hormone N-terminal Calcium regulation |
| title | Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae |
| title_full | Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae |
| title_fullStr | Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae |
| title_full_unstemmed | Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae |
| title_short | Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae |
| title_sort | Parathyroid hormone-related protein: a calcium regulatory factor in sea bream (Sparus aurata L.) larvae |
| topic | Hormone N-terminal Calcium regulation |
| topic_facet | Hormone N-terminal Calcium regulation |
| url | http://hdl.handle.net/10400.1/3992 |
| visible | 1 |
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