Bibliographic Details
| Summary: | POxylated polyurea dendrimer (PUREG4OOx48)-based nanoparticles were loaded with paclitaxel (PTX) and doxorubicin (DOX) and micronized with chitosan (CHT) by using supercritical CO2-assisted spray drying (SASD). Respirable, biocompatible, and biodegradable dry powder formulations (DPFs) were produced to effectively transport and deliver the chemotherapeutics with a controlled rate to the deep lung. In vitro studies performed with the use of the lung adenocarcinoma cell line showed that DOX@PUREG4OOx48 nanoparticles were much more cytotoxic than the free drug. Additionally, the DPFs did not show higher cytotoxicity than the respective nanoparticles, and DOX-DPFs showed a higher chemotherapeutic effect than PTX formulations in adenocarcinoma cells. |
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| Main Authors: | Restani, Rita B. |
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| Other Authors: | Pires, Rita F.; Tolmatcheva, Anna; Cabral, Rita; Baptista, Pedro V.; Fernandes, Alexandra R.; Casimiro, Teresa; Bonifácio, Vasco D. B.; Aguiar-Ricardo, Ana |
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| Subject: | chemotherapy composite particles dendrimers drug delivery pulmonary delivery General Chemistry |
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| Year: | 2018 |
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| Country: | Portugal |
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| Document type: | article |
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| Access type: | open access |
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| Associated institution: | Universidade Nova de Lisboa |
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| Language: | English |
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| Origin: | Repositório Institucional da UNL |
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