Publicação
Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts
| Resumo: | Neuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzymes involved in neurodegenerative etiology, namely in Alzheimer’s and Parkinson’s diseases, and against reactive oxygen and nitrogen species, all contributing factors to the progression of neurodegeneration. Results showed no significant enzyme inhibition but strong radical scavenging activities, particularly in the fourth fraction, extracted at the highest temperature (250 °C), highlighting their ability to retard oxidative and nitrosative stresses. At higher temperatures, fractions were composed of phenolic compounds and Maillard reaction products, a combination that contributed to their antioxidant activity and, consequently, their neuroprotective properties. All fractions were evaluated for the presence of iodine, 14 organochlorine and 7 organophosphorus pesticides, and pharmaceuticals used in Alzheimer’s and Parkinson’s diseases (14), psychiatric drugs (8), and metabolites (8). The fractions studied did not present any of the screened contaminants, and only fraction 1 of E. bicyclis should be used with caution due to iodine content. |
|---|---|
| Autores principais: | Gomes, Inês |
| Outros Autores: | Rodrigues, Helena; Rodrigues, Carla; Marques, Marta; Paíga, Paula; Paiva, Alexandre; Simões, Pedro; Fernandes, Virgínia Cruz; Vieira, Mónica; Delerue-Matos, Cristina; Soares, Cristina; Grosso, Clara |
| Assunto: | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Nova de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Institucional da UNL |
| _version_ | 1879446407552696320 |
|---|---|
| author | Gomes, Inês |
| author2 | Rodrigues, Helena Rodrigues, Carla Marques, Marta Paíga, Paula Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Vieira, Mónica Delerue-Matos, Cristina Soares, Cristina Grosso, Clara |
| author2_role | author author author author author author author author author author author |
| author_facet | Gomes, Inês Rodrigues, Helena Rodrigues, Carla Marques, Marta Paíga, Paula Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Vieira, Mónica Delerue-Matos, Cristina Soares, Cristina Grosso, Clara |
| author_role | author |
| contributor_name_str_mv | DQ - Departamento de Química LAQV@REQUIMTE MDPI - Multidisciplinary Digital Publishing Institute RUN |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Gomes, Inês\"},{\"Person.name\":\"Rodrigues, Helena\"},{\"Person.name\":\"Rodrigues, Carla\"},{\"Person.name\":\"Marques, Marta\"},{\"Person.name\":\"Paíga, Paula\"},{\"Person.name\":\"Paiva, Alexandre\"},{\"Person.name\":\"Simões, Pedro\"},{\"Person.name\":\"Fernandes, Virgínia Cruz\"},{\"Person.name\":\"Vieira, Mónica\"},{\"Person.name\":\"Delerue-Matos, Cristina\"},{\"Person.name\":\"Soares, Cristina\"},{\"Person.name\":\"Grosso, Clara\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | DQ - Departamento de Química LAQV@REQUIMTE MDPI - Multidisciplinary Digital Publishing Institute RUN |
| datacite.creators.creator.creatorName.fl_str_mv | Gomes, Inês Rodrigues, Helena Rodrigues, Carla Marques, Marta Paíga, Paula Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Vieira, Mónica Delerue-Matos, Cristina Soares, Cristina Grosso, Clara |
| datacite.date.Accepted.fl_str_mv | 2022-03-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-03-22T22:29:41Z |
| datacite.date.embargoed.fl_str_mv | 2023-03-22T22:29:41Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| datacite.titles.title.fl_str_mv | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| dc.contributor.none.fl_str_mv | DQ - Departamento de Química LAQV@REQUIMTE MDPI - Multidisciplinary Digital Publishing Institute RUN |
| dc.creator.none.fl_str_mv | Gomes, Inês Rodrigues, Helena Rodrigues, Carla Marques, Marta Paíga, Paula Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Vieira, Mónica Delerue-Matos, Cristina Soares, Cristina Grosso, Clara |
| dc.date.Accepted.fl_str_mv | 2022-03-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-03-22T22:29:41Z |
| dc.date.embargoed.fl_str_mv | 2023-03-22T22:29:41Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10362/151086 |
| dc.language.none.fl_str_mv | eng |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| dc.title.fl_str_mv | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Neuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzymes involved in neurodegenerative etiology, namely in Alzheimer’s and Parkinson’s diseases, and against reactive oxygen and nitrogen species, all contributing factors to the progression of neurodegeneration. Results showed no significant enzyme inhibition but strong radical scavenging activities, particularly in the fourth fraction, extracted at the highest temperature (250 °C), highlighting their ability to retard oxidative and nitrosative stresses. At higher temperatures, fractions were composed of phenolic compounds and Maillard reaction products, a combination that contributed to their antioxidant activity and, consequently, their neuroprotective properties. All fractions were evaluated for the presence of iodine, 14 organochlorine and 7 organophosphorus pesticides, and pharmaceuticals used in Alzheimer’s and Parkinson’s diseases (14), psychiatric drugs (8), and metabolites (8). The fractions studied did not present any of the screened contaminants, and only fraction 1 of E. bicyclis should be used with caution due to iodine content. |
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| person_str_mv | Gomes, Inês Rodrigues, Helena Rodrigues, Carla Marques, Marta Paíga, Paula Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Vieira, Mónica Delerue-Matos, Cristina Soares, Cristina Grosso, Clara |
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| spelling | engenNeuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzymes involved in neurodegenerative etiology, namely in Alzheimer’s and Parkinson’s diseases, and against reactive oxygen and nitrogen species, all contributing factors to the progression of neurodegeneration. Results showed no significant enzyme inhibition but strong radical scavenging activities, particularly in the fourth fraction, extracted at the highest temperature (250 °C), highlighting their ability to retard oxidative and nitrosative stresses. At higher temperatures, fractions were composed of phenolic compounds and Maillard reaction products, a combination that contributed to their antioxidant activity and, consequently, their neuroprotective properties. All fractions were evaluated for the presence of iodine, 14 organochlorine and 7 organophosphorus pesticides, and pharmaceuticals used in Alzheimer’s and Parkinson’s diseases (14), psychiatric drugs (8), and metabolites (8). The fractions studied did not present any of the screened contaminants, and only fraction 1 of E. bicyclis should be used with caution due to iodine content.application/pdfenEvaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water ExtractsGomes, InêsRodrigues, HelenaRodrigues, CarlaMarques, MartaPaíga, PaulaPaiva, AlexandreSimões, PedroFernandes, Virgínia CruzVieira, MónicaDelerue-Matos, CristinaSoares, CristinaGrosso, ClaraDQ - Departamento de QuímicaLAQV@REQUIMTEMDPI - Multidisciplinary Digital Publishing InstituteHostingInstitutionOrganizationalRUNe-mailmailto:run@unl.ptrun@unl.ptISSNIsPartOf2304-8158URNIsPartOfPURE: 56631514URNIsPartOfPURE UUID: ae1de41f-fc7a-418a-b04f-ffe5b5094b65URNIsPartOfScopus: 85126323191URNIsPartOfWOS: 000773359000001DOIIsPartOf10.3390/foods110507462023-03-22T22:29:41Z2022-03-012022-03-01T00:00:00ZHandlehttp://hdl.handle.net/10362/151086http://purl.org/coar/access_right/c_abf2open accessIodineMaillard reactionNeuroprotectionNitrosative stressOxidative stressPesticidesPharmaceuticalsSeaweedsTotal phenolic contentFood ScienceMicrobiologyHealth(social science)Health Professions (miscellaneous)Plant Science748696 bytesFundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processesinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PTUIDB/50006/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processesinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PTUIDP/50006/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PTIF/01146/2015/CP1293/CT0003Investigador FCTCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruitsinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F109153%2F2015/PTSFRH/BPD/109153/2015POR_NORTECrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://run.unl.pt/bitstreams/c7c3a42b-6ed1-4dc5-a3f1-82839a229987/download |
| spellingShingle | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts Gomes, Inês Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| status | SINGLETON |
| subject.fl_str_mv | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| title | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_full | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_fullStr | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_full_unstemmed | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_short | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_sort | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| topic | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| topic_facet | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content Food Science Microbiology Health(social science) Health Professions (miscellaneous) Plant Science |
| url | http://hdl.handle.net/10362/151086 |
| visible | 1 |