Publication
Asymmetrical subcortical plasticity entails cognitive progression in older individuals
| Summary: | Structural brain asymmetries have been associated with cognition. However, it is not known to what extent neuropsychological parameters and structural laterality covary with aging. Seventy-five subjects drawn from a larger normal aging cohort were evaluated in terms of MRI and neuropsychological parameters at two moments (M1 and M2), 18 months apart. In this time frame, asymmetry as measured by structural laterality index (ΔLI) was stable regarding both direction and magnitude in all areas. However, a significantly higher dispersion for this variation was observed in subcortical over cortical areas. Subjects with extreme increase in rightward lateralization of the caudate revealed increased M1 to M2 Stroop interference scores, but also a worsening of general cognition (MMSE). In contrast, subjects showing extreme increase in leftward lateralization of the thalamus presented higher increase in Stroop interference scores. In conclusion, while a decline in cognitive function was observed in the entire sample, regional brain asymmetries were relatively stable. Neuropsychological trajectories were associated with laterality changes in subcortical regions. |
|---|---|
| Main Authors: | Esteves, Madalena |
| Other Authors: | Moreira, Pedro S.; Marques, Paulo; Castanho, Teresa Jesus Costa; Magalhães, Ricardo; Amorim, Liliana Patrícia Carvalho; Nunes, José Carlos Leitão Portugal; Soares, José M.; Coelho, Ana; Almeida, Armando; Santos, Nadine Correia; Sousa, Nuno; Leite-Almeida, Hugo |
| Subject: | Aging Cognition MRI Structural laterality MMSE Stroop Ciências Médicas::Medicina Básica |
| Year: | 2019 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Universidade do Minho |
| Language: | English |
| Origin: | RepositóriUM - Universidade do Minho |
| _version_ | 1877775256277483520 |
|---|---|
| author | Esteves, Madalena |
| author2 | Moreira, Pedro S. Marques, Paulo Castanho, Teresa Jesus Costa Magalhães, Ricardo Amorim, Liliana Patrícia Carvalho Nunes, José Carlos Leitão Portugal Soares, José M. Coelho, Ana Almeida, Armando Santos, Nadine Correia Sousa, Nuno Leite-Almeida, Hugo |
| author2_role | author author author author author author author author author author author author |
| author_facet | Esteves, Madalena Moreira, Pedro S. Marques, Paulo Castanho, Teresa Jesus Costa Magalhães, Ricardo Amorim, Liliana Patrícia Carvalho Nunes, José Carlos Leitão Portugal Soares, José M. Coelho, Ana Almeida, Armando Santos, Nadine Correia Sousa, Nuno Leite-Almeida, Hugo |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Esteves, Madalena\"},{\"Person.name\":\"Moreira, Pedro S.\"},{\"Person.name\":\"Marques, Paulo\"},{\"Person.name\":\"Castanho, Teresa Jesus Costa\"},{\"Person.name\":\"Magalhães, Ricardo\"},{\"Person.name\":\"Amorim, Liliana Patrícia Carvalho\"},{\"Person.name\":\"Nunes, José Carlos Leitão Portugal\"},{\"Person.name\":\"Soares, José M.\"},{\"Person.name\":\"Coelho, Ana\"},{\"Person.name\":\"Almeida, Armando\"},{\"Person.name\":\"Santos, Nadine Correia\"},{\"Person.name\":\"Sousa, Nuno\"},{\"Person.name\":\"Leite-Almeida, Hugo\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Esteves, Madalena Moreira, Pedro S. Marques, Paulo Castanho, Teresa Jesus Costa Magalhães, Ricardo Amorim, Liliana Patrícia Carvalho Nunes, José Carlos Leitão Portugal Soares, José M. Coelho, Ana Almeida, Armando Santos, Nadine Correia Sousa, Nuno Leite-Almeida, Hugo |
| datacite.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Aging Cognition MRI Structural laterality MMSE Stroop Ciências Médicas::Medicina Básica |
| datacite.titles.title.fl_str_mv | Asymmetrical subcortical plasticity entails cognitive progression in older individuals |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Esteves, Madalena Moreira, Pedro S. Marques, Paulo Castanho, Teresa Jesus Costa Magalhães, Ricardo Amorim, Liliana Patrícia Carvalho Nunes, José Carlos Leitão Portugal Soares, José M. Coelho, Ana Almeida, Armando Santos, Nadine Correia Sousa, Nuno Leite-Almeida, Hugo |
| dc.date.Accepted.fl_str_mv | 2019-01-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/57980 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.cclincense.fl_str_mv | https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | Aging Cognition MRI Structural laterality MMSE Stroop Ciências Médicas::Medicina Básica |
| dc.title.fl_str_mv | Asymmetrical subcortical plasticity entails cognitive progression in older individuals |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Structural brain asymmetries have been associated with cognition. However, it is not known to what extent neuropsychological parameters and structural laterality covary with aging. Seventy-five subjects drawn from a larger normal aging cohort were evaluated in terms of MRI and neuropsychological parameters at two moments (M1 and M2), 18 months apart. In this time frame, asymmetry as measured by structural laterality index (ΔLI) was stable regarding both direction and magnitude in all areas. However, a significantly higher dispersion for this variation was observed in subcortical over cortical areas. Subjects with extreme increase in rightward lateralization of the caudate revealed increased M1 to M2 Stroop interference scores, but also a worsening of general cognition (MMSE). In contrast, subjects showing extreme increase in leftward lateralization of the thalamus presented higher increase in Stroop interference scores. In conclusion, while a decline in cognitive function was observed in the entire sample, regional brain asymmetries were relatively stable. Neuropsychological trajectories were associated with laterality changes in subcortical regions. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | rum_dc8967ce4ceb8cca0d7c123dceeaa45a |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/57980 |
| inst_facet_str | urn:organizationAcronym:repositorium{{{_:::_}}}Universidade do Minho |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/57980 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Esteves, Madalena Moreira, Pedro S. Marques, Paulo Castanho, Teresa Jesus Costa Magalhães, Ricardo Amorim, Liliana Patrícia Carvalho Nunes, José Carlos Leitão Portugal Soares, José M. Coelho, Ana Almeida, Armando Santos, Nadine Correia Sousa, Nuno Leite-Almeida, Hugo |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Wiley |
| repo_facet_str | urn:repositoryAcronym:rum{{{_:::_}}}RepositóriUM - Universidade do Minho |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engWileyporStructural brain asymmetries have been associated with cognition. However, it is not known to what extent neuropsychological parameters and structural laterality covary with aging. Seventy-five subjects drawn from a larger normal aging cohort were evaluated in terms of MRI and neuropsychological parameters at two moments (M1 and M2), 18 months apart. In this time frame, asymmetry as measured by structural laterality index (ΔLI) was stable regarding both direction and magnitude in all areas. However, a significantly higher dispersion for this variation was observed in subcortical over cortical areas. Subjects with extreme increase in rightward lateralization of the caudate revealed increased M1 to M2 Stroop interference scores, but also a worsening of general cognition (MMSE). In contrast, subjects showing extreme increase in leftward lateralization of the thalamus presented higher increase in Stroop interference scores. In conclusion, while a decline in cognitive function was observed in the entire sample, regional brain asymmetries were relatively stable. Neuropsychological trajectories were associated with laterality changes in subcortical regions.application/pdfporAsymmetrical subcortical plasticity entails cognitive progression in older individualsEsteves, MadalenaMoreira, Pedro S.Marques, PauloCastanho, Teresa Jesus CostaMagalhães, RicardoAmorim, Liliana Patrícia CarvalhoNunes, José Carlos Leitão PortugalSoares, José M.Coelho, AnaAlmeida, ArmandoSantos, Nadine CorreiaSousa, NunoLeite-Almeida, HugoHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONEsteves, M., Moreira, P. S., Marques, P., Castanho, T. C., Magalhães, R., Amorim, L., ... & Santos, N. C. (2019). Asymmetrical subcortical plasticity entails cognitive progression in older individuals. Aging Cell, e12857PMID30578611ISSNIsPartOf1474-9718EISSNIsPartOf1474-9726DOIIsPartOf10.1111/acel.1285720192019-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/57980http://purl.org/coar/access_right/c_abf2open accessAgingCognitionMRIStructural lateralityMMSEStroophttp://www.oecd.org/science/inno/38235147.pdfFields of Science and Technology (FOS)Ciências Médicas::Medicina Básica1403298 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2019https://creativecommons.org/licenses/by/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdfhttps://repositorium.uminho.pt/bitstreams/475165f7-a186-4335-a116-799f44042324/download |
| spellingShingle | Asymmetrical subcortical plasticity entails cognitive progression in older individuals Esteves, Madalena Aging Cognition MRI Structural laterality MMSE Stroop Ciências Médicas::Medicina Básica |
| status | SINGLETON |
| subject.fl_str_mv | Aging Cognition MRI Structural laterality MMSE Stroop |
| subject.other.fl_str_mv | Ciências Médicas::Medicina Básica |
| title | Asymmetrical subcortical plasticity entails cognitive progression in older individuals |
| title_full | Asymmetrical subcortical plasticity entails cognitive progression in older individuals |
| title_fullStr | Asymmetrical subcortical plasticity entails cognitive progression in older individuals |
| title_full_unstemmed | Asymmetrical subcortical plasticity entails cognitive progression in older individuals |
| title_short | Asymmetrical subcortical plasticity entails cognitive progression in older individuals |
| title_sort | Asymmetrical subcortical plasticity entails cognitive progression in older individuals |
| topic | Aging Cognition MRI Structural laterality MMSE Stroop Ciências Médicas::Medicina Básica |
| topic_facet | Aging Cognition MRI Structural laterality MMSE Stroop Ciências Médicas::Medicina Básica |
| url | https://hdl.handle.net/1822/57980 |
| visible | 1 |
Funded activities
No funded projects found.