Publicação
Skin mechanobiology and biomechanics: from homeostasis to wound healing
| Resumo: | Human skin represents the largest organ in the body by surface area, acting as a protective barrier from the environment. It constantly counteracts extrinsic and intrinsic mechanical forces during our daily lives. This is because the skin has remarkable biomechanical properties that are uniquely suited to its function. While it is relevant to know how skin tissue deforms and fails, it is even more important to understand how mechanical forces act on skin tissue to maintain tissue physiology and to regulate inherent biological processes such as wound healing. Skin contraction during wound healing is an example of how mechanical stimuli are important to wound closure. However, the scar formed after skin repair is a downside effect of skin mechanical contraction. Awareness of these processes has potentiated the creation of therapies to reduce scarring, but since the underlying mechanobiological mechanisms are not fully understood, there is still space for improvement. This chapter reviews the state of the art of skin biomechanics and mechanobiology at homeostasis and wound healing. The impact of the mechanical properties of the wounds on the rate and quality of wound healing are analyzed. The way this knowledge can improve wound healing and relieve scarring through new therapies is further discussed. |
|---|---|
| Autores principais: | Fernandes, Maria G. |
| Outros Autores: | Silva, Lucília Pereira; Marques, A. P. |
| Assunto: | Biomechanics Mechanobiology Skin Wound healing |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | capítulo de livro |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1877776501812756480 |
|---|---|
| author | Fernandes, Maria G. |
| author2 | Silva, Lucília Pereira Marques, A. P. |
| author2_role | author author |
| author_facet | Fernandes, Maria G. Silva, Lucília Pereira Marques, A. P. |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Fernandes, Maria G.\"},{\"Person.name\":\"Silva, Lucília Pereira\"},{\"Person.name\":\"Marques, A. P.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Fernandes, Maria G. Silva, Lucília Pereira Marques, A. P. |
| datacite.date.Accepted.fl_str_mv | 2019-08-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Biomechanics Mechanobiology Skin Wound healing |
| datacite.titles.title.fl_str_mv | Skin mechanobiology and biomechanics: from homeostasis to wound healing |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Fernandes, Maria G. Silva, Lucília Pereira Marques, A. P. |
| dc.date.Accepted.fl_str_mv | 2019-08-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/61296 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Elsevier |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Biomechanics Mechanobiology Skin Wound healing |
| dc.title.fl_str_mv | Skin mechanobiology and biomechanics: from homeostasis to wound healing |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_3248 |
| description | Human skin represents the largest organ in the body by surface area, acting as a protective barrier from the environment. It constantly counteracts extrinsic and intrinsic mechanical forces during our daily lives. This is because the skin has remarkable biomechanical properties that are uniquely suited to its function. While it is relevant to know how skin tissue deforms and fails, it is even more important to understand how mechanical forces act on skin tissue to maintain tissue physiology and to regulate inherent biological processes such as wound healing. Skin contraction during wound healing is an example of how mechanical stimuli are important to wound closure. However, the scar formed after skin repair is a downside effect of skin mechanical contraction. Awareness of these processes has potentiated the creation of therapies to reduce scarring, but since the underlying mechanobiological mechanisms are not fully understood, there is still space for improvement. This chapter reviews the state of the art of skin biomechanics and mechanobiology at homeostasis and wound healing. The impact of the mechanical properties of the wounds on the rate and quality of wound healing are analyzed. The way this knowledge can improve wound healing and relieve scarring through new therapies is further discussed. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | bookPart |
| id | rum_cdd366ca9e91405dde10a253dbd21aa6 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/61296 |
| inst_facet_str | urn:organizationAcronym:repositorium{{{_:::_}}}Universidade do Minho |
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| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
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| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/61296 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Fernandes, Maria G. Silva, Lucília Pereira Marques, A. P. |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Elsevier |
| repo_facet_str | urn:repositoryAcronym:rum{{{_:::_}}}RepositóriUM - Universidade do Minho |
| reponame_str | RepositóriUM - Universidade do Minho |
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| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engElsevierporHuman skin represents the largest organ in the body by surface area, acting as a protective barrier from the environment. It constantly counteracts extrinsic and intrinsic mechanical forces during our daily lives. This is because the skin has remarkable biomechanical properties that are uniquely suited to its function. While it is relevant to know how skin tissue deforms and fails, it is even more important to understand how mechanical forces act on skin tissue to maintain tissue physiology and to regulate inherent biological processes such as wound healing. Skin contraction during wound healing is an example of how mechanical stimuli are important to wound closure. However, the scar formed after skin repair is a downside effect of skin mechanical contraction. Awareness of these processes has potentiated the creation of therapies to reduce scarring, but since the underlying mechanobiological mechanisms are not fully understood, there is still space for improvement. This chapter reviews the state of the art of skin biomechanics and mechanobiology at homeostasis and wound healing. The impact of the mechanical properties of the wounds on the rate and quality of wound healing are analyzed. The way this knowledge can improve wound healing and relieve scarring through new therapies is further discussed.application/pdfporSkin mechanobiology and biomechanics: from homeostasis to wound healingFernandes, Maria G.Silva, Lucília PereiraMarques, A. P.HostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONFernandes M. G., da Silva L. P., Marques A. P. Skin Mechanobiology and Biomechanics: From Homeostasis to Wound Healing, Advances in Biomechanics and Tissue Regeneration, pp. 343-360, doi:10.1016/B978-0-12-816390-0.00017-0, 2019ISBNIsPartOf978-0-12-816390-0DOIIsPartOf10.1016/B978-0-12-816390-0.00017-02019-082019-08-01T00:00:00ZHandlehttps://hdl.handle.net/1822/61296http://purl.org/coar/access_right/c_abf2open accessBiomechanicsMechanobiologySkinWound healing2192796 bytesliteraturehttp://purl.org/coar/resource_type/c_3248book parthttp://purl.org/coar/access_right/c_abf2application/pdfhttps://repositorium.uminho.pt/bitstreams/832bd923-1093-41b7-bf3e-5f84beefd9f4/download |
| spellingShingle | Skin mechanobiology and biomechanics: from homeostasis to wound healing Fernandes, Maria G. Biomechanics Mechanobiology Skin Wound healing |
| status | SINGLETON |
| subject.fl_str_mv | Biomechanics Mechanobiology Skin Wound healing |
| title | Skin mechanobiology and biomechanics: from homeostasis to wound healing |
| title_full | Skin mechanobiology and biomechanics: from homeostasis to wound healing |
| title_fullStr | Skin mechanobiology and biomechanics: from homeostasis to wound healing |
| title_full_unstemmed | Skin mechanobiology and biomechanics: from homeostasis to wound healing |
| title_short | Skin mechanobiology and biomechanics: from homeostasis to wound healing |
| title_sort | Skin mechanobiology and biomechanics: from homeostasis to wound healing |
| topic | Biomechanics Mechanobiology Skin Wound healing |
| topic_facet | Biomechanics Mechanobiology Skin Wound healing |
| url | https://hdl.handle.net/1822/61296 |
| visible | 1 |
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