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In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering

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Summary:In this study, we manufactured various ratios of polycaprolactone (PCL)/gelatin (GE) highly aligned electrospun nanofibrous scaffolds (ENs) to investigate the effects of polymer ratio on tenogenic differentiation activity. For biological assessments, the cell proliferation rate was optimal in the PCL/GE (9:1) group. Interestingly, however, the tenogenic differentiation rate was best for the PCL/GE (7:3) group. From our outcomes, we established that a poly-blending mix of PCL/GE (7:3) is a promising ratio for tenogenic differentiation. Thus, our findings may provide for an effective mesh to promote tenogenic differentiation of ENs in future tendon tissue engineering applications.
Main Authors:Lee, Sang Jin
Other Authors:Kim, Han-Jun; Heo, Min; Lee, Hye-Rim; Choi, Eun-Ji; Kim, Hyosung; Lee, Donghyun; Reis, R. L.; Do, Sun Hee; Kwon, Il Keun
Subject:Electrospinning Gelatin Highly aligned nanofiber Polycaprolactone Tendon tissue engineering applications
Year:2019
Country:Portugal
Document type:article
Access type:open access
Associated institution:Universidade do Minho
Language:English
Origin:RepositóriUM - Universidade do Minho

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