Publicação
In vitro and in vivo assessments of an optimal polyblend composition of polycaprolactone/gelatin nanofibrous scaffolds for Achilles tendon tissue engineering
| Resumo: | In this study, we manufactured various ratios of polycaprolactone (PCL)/gelatin (GE) highly aligned electrospun nanofibrous scaffolds (ENs) to investigate the effects of polymer ratio on tenogenic differentiation activity. For biological assessments, the cell proliferation rate was optimal in the PCL/GE (9:1) group. Interestingly, however, the tenogenic differentiation rate was best for the PCL/GE (7:3) group. From our outcomes, we established that a poly-blending mix of PCL/GE (7:3) is a promising ratio for tenogenic differentiation. Thus, our findings may provide for an effective mesh to promote tenogenic differentiation of ENs in future tendon tissue engineering applications. |
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| Autores principais: | Lee, Sang Jin |
| Outros Autores: | Kim, Han-Jun; Heo, Min; Lee, Hye-Rim; Choi, Eun-Ji; Kim, Hyosung; Lee, Donghyun; Reis, R. L.; Do, Sun Hee; Kwon, Il Keun |
| Assunto: | Electrospinning Gelatin Highly aligned nanofiber Polycaprolactone Tendon tissue engineering applications |
| Ano: | 2019 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
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