Publicação
Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite
| Resumo: | This research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(ε-caprolactone) (∗PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabrication of fibrous meshes, by either electrospinning or wetspinning, were optimized. Stemming from a previous research activity on electrospinning of ∗PCL, ∗PCL/HNPs 3D meshes were developed, evaluating the influence of fabrication parameters on the fibres’ morphology. By exploiting the binding affinity of bisphosphonates for hydroxyapatite, a methodology was set up for obtaining a physical linkage between CD and HNPs, with the aim of having a dual bioactive system loaded into ∗PCL fibrous mats. Fibres loaded with either CD or CD–HNP particles were thus produced and analysed by scanning electron microscopy for their morphology and by energy dispersive X-ray spectroscopy for their elemental composition. |
|---|---|
| Autores principais: | Puppi, D. |
| Outros Autores: | Piras, A. M.; Chiellini, F.; Chiellini, E.; Martins, Albino; Leonor, I. B.; Neves, N. M.; Reis, R. L. |
| Assunto: | electrospinning wet-spinning star polymers bisphosphonates scaffolds tissue engineering |
| Ano: | 2011 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1877774558037016576 |
|---|---|
| author | Puppi, D. |
| author2 | Piras, A. M. Chiellini, F. Chiellini, E. Martins, Albino Leonor, I. B. Neves, N. M. Reis, R. L. |
| author2_role | author author author author author author author |
| author_facet | Puppi, D. Piras, A. M. Chiellini, F. Chiellini, E. Martins, Albino Leonor, I. B. Neves, N. M. Reis, R. L. |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Puppi, D.\"},{\"Person.name\":\"Piras, A. M.\"},{\"Person.name\":\"Chiellini, F.\"},{\"Person.name\":\"Chiellini, E.\"},{\"Person.name\":\"Martins, Albino\"},{\"Person.name\":\"Leonor, I. B.\"},{\"Person.name\":\"Neves, N. M.\"},{\"Person.name\":\"Reis, R. L.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Puppi, D. Piras, A. M. Chiellini, F. Chiellini, E. Martins, Albino Leonor, I. B. Neves, N. M. Reis, R. L. |
| datacite.date.Accepted.fl_str_mv | 2011-01-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | electrospinning wet-spinning star polymers bisphosphonates scaffolds tissue engineering |
| datacite.titles.title.fl_str_mv | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Puppi, D. Piras, A. M. Chiellini, F. Chiellini, E. Martins, Albino Leonor, I. B. Neves, N. M. Reis, R. L. |
| dc.date.Accepted.fl_str_mv | 2011-01-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/12818 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | electrospinning wet-spinning star polymers bisphosphonates scaffolds tissue engineering |
| dc.title.fl_str_mv | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | This research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(ε-caprolactone) (∗PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabrication of fibrous meshes, by either electrospinning or wetspinning, were optimized. Stemming from a previous research activity on electrospinning of ∗PCL, ∗PCL/HNPs 3D meshes were developed, evaluating the influence of fabrication parameters on the fibres’ morphology. By exploiting the binding affinity of bisphosphonates for hydroxyapatite, a methodology was set up for obtaining a physical linkage between CD and HNPs, with the aim of having a dual bioactive system loaded into ∗PCL fibrous mats. Fibres loaded with either CD or CD–HNP particles were thus produced and analysed by scanning electron microscopy for their morphology and by energy dispersive X-ray spectroscopy for their elemental composition. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | rum_7643f24f187ee62e95940427662fe8c2 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/12818 |
| inst_facet_str | urn:organizationAcronym:repositorium{{{_:::_}}}Universidade do Minho |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/12818 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Puppi, D. Piras, A. M. Chiellini, F. Chiellini, E. Martins, Albino Leonor, I. B. Neves, N. M. Reis, R. L. |
| publishDate | 2011 |
| publisher.none.fl_str_mv | Wiley |
| repo_facet_str | urn:repositoryAcronym:rum{{{_:::_}}}RepositóriUM - Universidade do Minho |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engWileyporThis research activity was aimed at the development of composite bioactive scaffolds made of biodegradable three-arm branched-star poly(ε-caprolactone) (∗PCL), hydroxyapatite nanoparticles (HNPs) and clodronate (CD), a bisphosphonate that has demonstrated efficacy in the treatment of various bone diseases and as an anti-inflammatory drug. During the experimental work, the processing conditions for the fabrication of fibrous meshes, by either electrospinning or wetspinning, were optimized. Stemming from a previous research activity on electrospinning of ∗PCL, ∗PCL/HNPs 3D meshes were developed, evaluating the influence of fabrication parameters on the fibres’ morphology. By exploiting the binding affinity of bisphosphonates for hydroxyapatite, a methodology was set up for obtaining a physical linkage between CD and HNPs, with the aim of having a dual bioactive system loaded into ∗PCL fibrous mats. Fibres loaded with either CD or CD–HNP particles were thus produced and analysed by scanning electron microscopy for their morphology and by energy dispersive X-ray spectroscopy for their elemental composition.application/pdfengOptimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatitePuppi, D.Piras, A. M.Chiellini, F.Chiellini, E.Martins, AlbinoLeonor, I. B.Neves, N. M.Reis, R. L.HostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptPMID20661867ISSNIsPartOf1932-7005DOIIsPartOf10.1002/term.31020112011-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/12818http://purl.org/coar/access_right/c_abf2open accesselectrospinningwet-spinningstar polymersbisphosphonatesscaffoldstissue engineering542212 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdfhttps://repositorium.uminho.pt/bitstreams/3939af28-015c-42c1-9bfb-f4f412d544d2/download |
| spellingShingle | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite Puppi, D. electrospinning wet-spinning star polymers bisphosphonates scaffolds tissue engineering |
| status | SINGLETON |
| subject.fl_str_mv | electrospinning wet-spinning star polymers bisphosphonates scaffolds tissue engineering |
| title | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite |
| title_full | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite |
| title_fullStr | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite |
| title_full_unstemmed | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite |
| title_short | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite |
| title_sort | Optimized electro- and wet-spinning techniques for the production of polymeric fibrous scaffolds loaded with bisphosphonate and hydroxyapatite |
| topic | electrospinning wet-spinning star polymers bisphosphonates scaffolds tissue engineering |
| topic_facet | electrospinning wet-spinning star polymers bisphosphonates scaffolds tissue engineering |
| url | https://hdl.handle.net/1822/12818 |
| visible | 1 |
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