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Lab-on-a-chip for measuring uric acid in biological fluids

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Resumo:This paper describes a lab-on-a-chip for measuring uric acid in serum, plasma or urine. The lab-on-a-chip is composed by two dies: one is fabricated in polystyrene and contains the microchannels and the other is fabricated through a CMOS process and contains the photodetector and readout electronics. The uric acid concentration is measured by using a mixture of 14 µl of infinityTM uric acid reagent with 0.25 µl of sample. The achieved sensitivity is 0.33 mg/dl (±0.6% of human being urine values), with a 1 mm lightpath. Using an optical absorption method, a maximum peak at wavelength λ = 494 nm, is detected.
Autores principais:Minas, Graça
Outros Autores:Martins, Júlio S.; Wilson, Cristina Pereira; Lima, Cristóvão F.; Wolffenbuttel, R. F.; Correia, J. H.
Assunto:Lab-on-a-chip Optical absorption Uric acid
Ano:2002
País:Portugal
Tipo de documento:comunicação em conferência
Tipo de acesso:acesso restrito
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho
Descrição
Resumo:This paper describes a lab-on-a-chip for measuring uric acid in serum, plasma or urine. The lab-on-a-chip is composed by two dies: one is fabricated in polystyrene and contains the microchannels and the other is fabricated through a CMOS process and contains the photodetector and readout electronics. The uric acid concentration is measured by using a mixture of 14 µl of infinityTM uric acid reagent with 0.25 µl of sample. The achieved sensitivity is 0.33 mg/dl (±0.6% of human being urine values), with a 1 mm lightpath. Using an optical absorption method, a maximum peak at wavelength λ = 494 nm, is detected.

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