Publicação
Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study
| Resumo: | Ocular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradable polymeric PLGA nanoparticles constitute a suitable alternative to topical eye administration, as they can improve ocular bioavailability and simultaneously reduce drug induced side effects. Moreover, their prolonged drug release can enhance patient treatment adherence as they require fewer administrations. Therefore, several formulations of PLGA based nanoparticles encapsulating dexibuprofen (active enantiomer of Ibuprofen) were prepared using the solvent displacement method employing different surfactants. The formulations have been characterized and their interactions with a customized lipid corneal membrane model were studied. Ex vivo permeation through ocular tissues and in vivo anti-inflammatory efficacy have also been studied. |
|---|---|
| Autores principais: | Sánchez-López, Elena |
| Outros Autores: | Esteruelas, Gerard; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Cano, Amanda; Calpena, Ana Cristina; Ettcheto, Miren; Camins, Antoni; Alsafi, Zaid; Souto, Eliana B.; García, Maria Luisa; Pujol, Montserrat |
| Assunto: | dexibuprofen drug delivery system nanoparticles PLGA |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1877775537124933632 |
|---|---|
| author | Sánchez-López, Elena |
| author2 | Esteruelas, Gerard Ortiz, Alba Espina, Marta Prat, Josefina Muñoz, Montserrat Cano, Amanda Calpena, Ana Cristina Ettcheto, Miren Camins, Antoni Alsafi, Zaid Souto, Eliana B. García, Maria Luisa Pujol, Montserrat |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Sánchez-López, Elena Esteruelas, Gerard Ortiz, Alba Espina, Marta Prat, Josefina Muñoz, Montserrat Cano, Amanda Calpena, Ana Cristina Ettcheto, Miren Camins, Antoni Alsafi, Zaid Souto, Eliana B. García, Maria Luisa Pujol, Montserrat |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Sánchez-López, Elena\"},{\"Person.name\":\"Esteruelas, Gerard\"},{\"Person.name\":\"Ortiz, Alba\"},{\"Person.name\":\"Espina, Marta\"},{\"Person.name\":\"Prat, Josefina\"},{\"Person.name\":\"Muñoz, Montserrat\"},{\"Person.name\":\"Cano, Amanda\"},{\"Person.name\":\"Calpena, Ana Cristina\"},{\"Person.name\":\"Ettcheto, Miren\"},{\"Person.name\":\"Camins, Antoni\"},{\"Person.name\":\"Alsafi, Zaid\"},{\"Person.name\":\"Souto, Eliana B.\"},{\"Person.name\":\"García, Maria Luisa\"},{\"Person.name\":\"Pujol, Montserrat\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Sánchez-López, Elena Esteruelas, Gerard Ortiz, Alba Espina, Marta Prat, Josefina Muñoz, Montserrat Cano, Amanda Calpena, Ana Cristina Ettcheto, Miren Camins, Antoni Alsafi, Zaid Souto, Eliana B. García, Maria Luisa Pujol, Montserrat |
| datacite.date.Accepted.fl_str_mv | 2020-04-10T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | dexibuprofen drug delivery system nanoparticles PLGA |
| datacite.titles.title.fl_str_mv | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Sánchez-López, Elena Esteruelas, Gerard Ortiz, Alba Espina, Marta Prat, Josefina Muñoz, Montserrat Cano, Amanda Calpena, Ana Cristina Ettcheto, Miren Camins, Antoni Alsafi, Zaid Souto, Eliana B. García, Maria Luisa Pujol, Montserrat |
| dc.date.Accepted.fl_str_mv | 2020-04-10T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/64929 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | dexibuprofen drug delivery system nanoparticles PLGA |
| dc.title.fl_str_mv | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Ocular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradable polymeric PLGA nanoparticles constitute a suitable alternative to topical eye administration, as they can improve ocular bioavailability and simultaneously reduce drug induced side effects. Moreover, their prolonged drug release can enhance patient treatment adherence as they require fewer administrations. Therefore, several formulations of PLGA based nanoparticles encapsulating dexibuprofen (active enantiomer of Ibuprofen) were prepared using the solvent displacement method employing different surfactants. The formulations have been characterized and their interactions with a customized lipid corneal membrane model were studied. Ex vivo permeation through ocular tissues and in vivo anti-inflammatory efficacy have also been studied. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | rum_53880b20ee2b2a14d25a251a19b915df |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/64929 |
| inst_facet_str | urn:organizationAcronym:repositorium{{{_:::_}}}Universidade do Minho |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/64929 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Sánchez-López, Elena Esteruelas, Gerard Ortiz, Alba Espina, Marta Prat, Josefina Muñoz, Montserrat Cano, Amanda Calpena, Ana Cristina Ettcheto, Miren Camins, Antoni Alsafi, Zaid Souto, Eliana B. García, Maria Luisa Pujol, Montserrat |
| publishDate | 2020 |
| publisher.none.fl_str_mv | MDPI |
| repo_facet_str | urn:repositoryAcronym:rum{{{_:::_}}}RepositóriUM - Universidade do Minho |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engMDPIporOcular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradable polymeric PLGA nanoparticles constitute a suitable alternative to topical eye administration, as they can improve ocular bioavailability and simultaneously reduce drug induced side effects. Moreover, their prolonged drug release can enhance patient treatment adherence as they require fewer administrations. Therefore, several formulations of PLGA based nanoparticles encapsulating dexibuprofen (active enantiomer of Ibuprofen) were prepared using the solvent displacement method employing different surfactants. The formulations have been characterized and their interactions with a customized lipid corneal membrane model were studied. Ex vivo permeation through ocular tissues and in vivo anti-inflammatory efficacy have also been studied.application/pdfporDexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction studySánchez-López, ElenaEsteruelas, GerardOrtiz, AlbaEspina, MartaPrat, JosefinaMuñoz, MontserratCano, AmandaCalpena, Ana CristinaEttcheto, MirenCamins, AntoniAlsafi, ZaidSouto, Eliana B.García, Maria LuisaPujol, MontserratHostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONSánchez-López, Elena; Esteruelas, Gerard; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Cano, Amanda; Calpena, Ana Cristina; Ettcheto, Miren; Camins, Antoni; Alsafi, Zaid; Souto, Eliana; García, Maria Luisa; Pujol, Montserrat, Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study. Nanomaterials, 10(4), 720, 2020EISSNIsPartOf2079-4991DOIIsPartOf10.3390/nano100407202020-04-102020-04-10T00:00:00ZHandlehttps://hdl.handle.net/1822/64929http://purl.org/coar/access_right/c_abf2open accessdexibuprofendrug delivery systemnanoparticlesPLGA5578725 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2020-04-10http://creativecommons.org/licenses/by/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdfhttps://repositorium.uminho.pt/bitstreams/57625a39-5568-494d-9f68-e70fe73f0a93/download |
| spellingShingle | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study Sánchez-López, Elena dexibuprofen drug delivery system nanoparticles PLGA |
| status | SINGLETON |
| subject.fl_str_mv | dexibuprofen drug delivery system nanoparticles PLGA |
| title | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study |
| title_full | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study |
| title_fullStr | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study |
| title_full_unstemmed | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study |
| title_short | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study |
| title_sort | Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocular interaction study |
| topic | dexibuprofen drug delivery system nanoparticles PLGA |
| topic_facet | dexibuprofen drug delivery system nanoparticles PLGA |
| url | https://hdl.handle.net/1822/64929 |
| visible | 1 |
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