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Protein-based materials as cancer in vitro models

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Resumo:The extracellular matrix (ECM) plays an active role in tumor progression. Increasing evidence points out a permissive tumor microenvironment that enhances malignancy and makes drug targeting a more difficult task. Protein-based materials as a substrate for cell culture hydrogels offer the advantage of having the presence of cell-responsive sequences as opposed to synthetic polymer-based hydrogels. This is important for cancer research to evaluate different aspects of tumor proliferation, such as cell growth, cell adhesion, and cell invasion. The gold standard for protein-based hydrogels has been Matrigel. However, its ill-defined nature, low reproducibility, and weak mechanical properties do not make it an ideal scaffold for more rigorous cancer research â especially in the mechanotransduction field. Therefore, alternatives are very much in need. Herein, it is presented the main proteinaceous materials used as scaffolds to model tumor development: collagen, gelatin, fibrin, and silk fibroin.
Autores principais:Ramos, P.
Outros Autores:Maia, F. Raquel; Reis, R. L.; Oliveira, Joaquim M.
Assunto:Biomaterials Collagen Fibrin Gelatin Hydrogels in vitro models Silk Fibroin Tumor microenvironment
Ano:2024
País:Portugal
Tipo de documento:capítulo de livro
Tipo de acesso:acesso aberto
Instituição associada:Universidade do Minho
Idioma:inglês
Origem:RepositóriUM - Universidade do Minho

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