Publicação
Electrospun nanostructured scaffolds for tissue engineering applications
| Resumo: | Despite being known for decades (since 1934), electrospinning has emerged recently as a very widespread technology to produce synthetic nanofibrous structures. These structures have morphologies and fiber diameters in a range comparable with those found in the extracellular matrix of human tissues. Therefore, nanofibrous scaffolds are intended to provide improved environments for cell attachment, migration, proliferation and differentiation when compared with traditional scaffolds. In addition, the process versatility and the highly specific surface area of nanofiber meshes may facilitate their use as local drug-release systems. Common electrospun nanofiber meshes are characterized by a random orientation. However, in some special cases, aligned distributions of the fibers can be obtained, with an interconnected microporous structure. The characteristic pore sizes and the inherent planar structure of the meshes can be detrimental for the desired cell infiltration into the inner regions, and eventually compromise tissue regeneration. Several strategies can be followed to overcome these limitations, and are discussed in detail here. |
|---|---|
| Autores principais: | Martins, Albino |
| Outros Autores: | Araújo, J. V.; Reis, R. L.; Neves, N. M. |
| Assunto: | Biodegradable Nanofibers Control porosity Drugs-release systems Electrospinning Fiber alignment in vitro studies in vivo studies Scaffolds Synthectic ECM analogue Tissue engineering drug-release systems synthetic ECM analogue Biodegradable nanofibers |
| Ano: | 2007 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1877776826082787328 |
|---|---|
| author | Martins, Albino |
| author2 | Araújo, J. V. Reis, R. L. Neves, N. M. |
| author2_role | author author author |
| author_facet | Martins, Albino Araújo, J. V. Reis, R. L. Neves, N. M. |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Martins, Albino\"},{\"Person.name\":\"Araújo, J. V.\"},{\"Person.name\":\"Reis, R. L.\"},{\"Person.name\":\"Neves, N. M.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Martins, Albino Araújo, J. V. Reis, R. L. Neves, N. M. |
| datacite.date.Accepted.fl_str_mv | 2007-01-01T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Biodegradable Nanofibers Control porosity Drugs-release systems Electrospinning Fiber alignment in vitro studies in vivo studies Scaffolds Synthectic ECM analogue Tissue engineering drug-release systems synthetic ECM analogue Biodegradable nanofibers |
| datacite.titles.title.fl_str_mv | Electrospun nanostructured scaffolds for tissue engineering applications |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Martins, Albino Araújo, J. V. Reis, R. L. Neves, N. M. |
| dc.date.Accepted.fl_str_mv | 2007-01-01T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/20207 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Future Medicine |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Biodegradable Nanofibers Control porosity Drugs-release systems Electrospinning Fiber alignment in vitro studies in vivo studies Scaffolds Synthectic ECM analogue Tissue engineering drug-release systems synthetic ECM analogue Biodegradable nanofibers |
| dc.title.fl_str_mv | Electrospun nanostructured scaffolds for tissue engineering applications |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Despite being known for decades (since 1934), electrospinning has emerged recently as a very widespread technology to produce synthetic nanofibrous structures. These structures have morphologies and fiber diameters in a range comparable with those found in the extracellular matrix of human tissues. Therefore, nanofibrous scaffolds are intended to provide improved environments for cell attachment, migration, proliferation and differentiation when compared with traditional scaffolds. In addition, the process versatility and the highly specific surface area of nanofiber meshes may facilitate their use as local drug-release systems. Common electrospun nanofiber meshes are characterized by a random orientation. However, in some special cases, aligned distributions of the fibers can be obtained, with an interconnected microporous structure. The characteristic pore sizes and the inherent planar structure of the meshes can be detrimental for the desired cell infiltration into the inner regions, and eventually compromise tissue regeneration. Several strategies can be followed to overcome these limitations, and are discussed in detail here. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | rum_29993f641ee34f71ca32a6c67280bbd9 |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/20207 |
| inst_facet_str | urn:organizationAcronym:repositorium{{{_:::_}}}Universidade do Minho |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/20207 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Martins, Albino Araújo, J. V. Reis, R. L. Neves, N. M. |
| publishDate | 2007 |
| publisher.none.fl_str_mv | Future Medicine |
| repo_facet_str | urn:repositoryAcronym:rum{{{_:::_}}}RepositóriUM - Universidade do Minho |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engFuture MedicineporDespite being known for decades (since 1934), electrospinning has emerged recently as a very widespread technology to produce synthetic nanofibrous structures. These structures have morphologies and fiber diameters in a range comparable with those found in the extracellular matrix of human tissues. Therefore, nanofibrous scaffolds are intended to provide improved environments for cell attachment, migration, proliferation and differentiation when compared with traditional scaffolds. In addition, the process versatility and the highly specific surface area of nanofiber meshes may facilitate their use as local drug-release systems. Common electrospun nanofiber meshes are characterized by a random orientation. However, in some special cases, aligned distributions of the fibers can be obtained, with an interconnected microporous structure. The characteristic pore sizes and the inherent planar structure of the meshes can be detrimental for the desired cell infiltration into the inner regions, and eventually compromise tissue regeneration. Several strategies can be followed to overcome these limitations, and are discussed in detail here.application/pdfporElectrospun nanostructured scaffolds for tissue engineering applicationsMartins, AlbinoAraújo, J. V.Reis, R. L.Neves, N. M.HostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptPMID18095855ISSNIsPartOf1743-5889DOIIsPartOf10.2217/17435889.2.6.92920072007-01-01T00:00:00ZHandlehttps://hdl.handle.net/1822/20207http://purl.org/coar/access_right/c_abf2open accessBiodegradableNanofibersControl porosityDrugs-release systemsElectrospinningFiber alignmentin vitro studiesin vivo studiesScaffoldsSynthectic ECM analogueTissue engineeringdrug-release systemssynthetic ECM analogueBiodegradable nanofibers702851 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal articlehttp://purl.org/coar/access_right/c_abf2application/pdfhttps://repositorium.uminho.pt/bitstreams/0d81c8c3-155d-4d30-b2b7-c86e4d48b901/download |
| spellingShingle | Electrospun nanostructured scaffolds for tissue engineering applications Martins, Albino Biodegradable Nanofibers Control porosity Drugs-release systems Electrospinning Fiber alignment in vitro studies in vivo studies Scaffolds Synthectic ECM analogue Tissue engineering drug-release systems synthetic ECM analogue Biodegradable nanofibers |
| status | SINGLETON |
| subject.fl_str_mv | Biodegradable Nanofibers Control porosity Drugs-release systems Electrospinning Fiber alignment in vitro studies in vivo studies Scaffolds Synthectic ECM analogue Tissue engineering drug-release systems synthetic ECM analogue Biodegradable nanofibers |
| title | Electrospun nanostructured scaffolds for tissue engineering applications |
| title_full | Electrospun nanostructured scaffolds for tissue engineering applications |
| title_fullStr | Electrospun nanostructured scaffolds for tissue engineering applications |
| title_full_unstemmed | Electrospun nanostructured scaffolds for tissue engineering applications |
| title_short | Electrospun nanostructured scaffolds for tissue engineering applications |
| title_sort | Electrospun nanostructured scaffolds for tissue engineering applications |
| topic | Biodegradable Nanofibers Control porosity Drugs-release systems Electrospinning Fiber alignment in vitro studies in vivo studies Scaffolds Synthectic ECM analogue Tissue engineering drug-release systems synthetic ECM analogue Biodegradable nanofibers |
| topic_facet | Biodegradable Nanofibers Control porosity Drugs-release systems Electrospinning Fiber alignment in vitro studies in vivo studies Scaffolds Synthectic ECM analogue Tissue engineering drug-release systems synthetic ECM analogue Biodegradable nanofibers |
| url | https://hdl.handle.net/1822/20207 |
| visible | 1 |
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