Publicação
Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications
| Resumo: | Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a piezoelectric biodegradable and biocompatible polymer suitable for tissue engineering applications. The incorporation of magnetostrictive cobalt ferrites (CFO) into PHBV matrix enables the production of magnetically responsive composites, which proved to be effective in the differentiation of a variety of cells and tissues. In this work, PHBV and PHBV with CFO nanoparticles were produced in the form of films, fibers and porous scaffolds and subjected to an experimental program allowing to evaluate the degradation process under biological conditions for a period up to 8 weeks. The morphology, physical, chemical and thermal properties were evaluated, together with the weight loss of the samples during the in vitro degradation assays. No major changes in the mentioned properties were found, thus proving its applicability for tissue engineering applications. Degradation was apparent from week 4 and onwards, leading to the conclusion that the degradation ratio of the material is suitable for a large range of tissue engineering applications. Further, it was found that the degradation of the samples maintain the biocompatibility of the materials for the pristine polymer, but can lead to cytotoxic effects when the magnetic CFO nanoparticles are exposed, being therefore needed, for magnetoactive applications, to substitute them by biocompatible ferrites, such as an iron oxide (Fe3O4). |
|---|---|
| Autores principais: | Amaro, Luis |
| Outros Autores: | Correia, Daniela M.; Martins, Pedro Manuel Abreu; Botelho, Gabriela; Carabineiro, Sónia A. C.; Ribeiro, Clarisse Marta Oliveira; Lanceros-Méndez, S. |
| Assunto: | piezoelectric materials poly(hydroxybutyrate-co-hydroxyvalerate) hydrolytic degradation tissue engineering |
| Ano: | 2020 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade do Minho |
| Idioma: | inglês |
| Origem: | RepositóriUM - Universidade do Minho |
| _version_ | 1877774791768801280 |
|---|---|
| author | Amaro, Luis |
| author2 | Correia, Daniela M. Martins, Pedro Manuel Abreu Botelho, Gabriela Carabineiro, Sónia A. C. Ribeiro, Clarisse Marta Oliveira Lanceros-Méndez, S. |
| author2_role | author author author author author author |
| author_facet | Amaro, Luis Correia, Daniela M. Martins, Pedro Manuel Abreu Botelho, Gabriela Carabineiro, Sónia A. C. Ribeiro, Clarisse Marta Oliveira Lanceros-Méndez, S. |
| author_role | author |
| contributor_name_str_mv | RepositóriUM - Universidade do Minho |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Amaro, Luis\"},{\"Person.name\":\"Correia, Daniela M.\"},{\"Person.name\":\"Martins, Pedro Manuel Abreu\"},{\"Person.name\":\"Botelho, Gabriela\"},{\"Person.name\":\"Carabineiro, Sónia A. C.\"},{\"Person.name\":\"Ribeiro, Clarisse Marta Oliveira\"},{\"Person.name\":\"Lanceros-Méndez, S.\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RepositóriUM - Universidade do Minho |
| datacite.creators.creator.creatorName.fl_str_mv | Amaro, Luis Correia, Daniela M. Martins, Pedro Manuel Abreu Botelho, Gabriela Carabineiro, Sónia A. C. Ribeiro, Clarisse Marta Oliveira Lanceros-Méndez, S. |
| datacite.date.Accepted.fl_str_mv | 2020-04-16T00:00:00Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | piezoelectric materials poly(hydroxybutyrate-co-hydroxyvalerate) hydrolytic degradation tissue engineering |
| datacite.titles.title.fl_str_mv | Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications |
| dc.contributor.none.fl_str_mv | RepositóriUM - Universidade do Minho |
| dc.creator.none.fl_str_mv | Amaro, Luis Correia, Daniela M. Martins, Pedro Manuel Abreu Botelho, Gabriela Carabineiro, Sónia A. C. Ribeiro, Clarisse Marta Oliveira Lanceros-Méndez, S. |
| dc.date.Accepted.fl_str_mv | 2020-04-16T00:00:00Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://hdl.handle.net/1822/65104 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.rights.rights.copyright.fl_str_mv | openAccess |
| dc.subject.none.fl_str_mv | piezoelectric materials poly(hydroxybutyrate-co-hydroxyvalerate) hydrolytic degradation tissue engineering |
| dc.title.fl_str_mv | Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a piezoelectric biodegradable and biocompatible polymer suitable for tissue engineering applications. The incorporation of magnetostrictive cobalt ferrites (CFO) into PHBV matrix enables the production of magnetically responsive composites, which proved to be effective in the differentiation of a variety of cells and tissues. In this work, PHBV and PHBV with CFO nanoparticles were produced in the form of films, fibers and porous scaffolds and subjected to an experimental program allowing to evaluate the degradation process under biological conditions for a period up to 8 weeks. The morphology, physical, chemical and thermal properties were evaluated, together with the weight loss of the samples during the in vitro degradation assays. No major changes in the mentioned properties were found, thus proving its applicability for tissue engineering applications. Degradation was apparent from week 4 and onwards, leading to the conclusion that the degradation ratio of the material is suitable for a large range of tissue engineering applications. Further, it was found that the degradation of the samples maintain the biocompatibility of the materials for the pristine polymer, but can lead to cytotoxic effects when the magnetic CFO nanoparticles are exposed, being therefore needed, for magnetoactive applications, to substitute them by biocompatible ferrites, such as an iron oxide (Fe3O4). |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | rum_15ae18f7b5f889bd003d86cbb2645f7c |
| identifier.url.fl_str_mv | https://hdl.handle.net/1822/65104 |
| inst_facet_str | urn:organizationAcronym:repositorium{{{_:::_}}}Universidade do Minho |
| instacron_str | repositorium |
| institution | Universidade do Minho |
| instname_str | Universidade do Minho |
| language | eng |
| network_acronym_str | rum |
| network_name_str | RepositóriUM - Universidade do Minho |
| oai_identifier_str | oai:repositorium.uminho.pt:1822/65104 |
| organization_str_mv | urn:organizationAcronym:repositorium |
| person_str_mv | Amaro, Luis Correia, Daniela M. Martins, Pedro Manuel Abreu Botelho, Gabriela Carabineiro, Sónia A. C. Ribeiro, Clarisse Marta Oliveira Lanceros-Méndez, S. |
| publishDate | 2020 |
| publisher.none.fl_str_mv | MDPI |
| repo_facet_str | urn:repositoryAcronym:rum{{{_:::_}}}RepositóriUM - Universidade do Minho |
| reponame_str | RepositóriUM - Universidade do Minho |
| repository_id_str | urn:repositoryAcronym:rum |
| service_str_mv | urn:repositoryAcronym:rum |
| spelling | engMDPIporPoly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a piezoelectric biodegradable and biocompatible polymer suitable for tissue engineering applications. The incorporation of magnetostrictive cobalt ferrites (CFO) into PHBV matrix enables the production of magnetically responsive composites, which proved to be effective in the differentiation of a variety of cells and tissues. In this work, PHBV and PHBV with CFO nanoparticles were produced in the form of films, fibers and porous scaffolds and subjected to an experimental program allowing to evaluate the degradation process under biological conditions for a period up to 8 weeks. The morphology, physical, chemical and thermal properties were evaluated, together with the weight loss of the samples during the in vitro degradation assays. No major changes in the mentioned properties were found, thus proving its applicability for tissue engineering applications. Degradation was apparent from week 4 and onwards, leading to the conclusion that the degradation ratio of the material is suitable for a large range of tissue engineering applications. Further, it was found that the degradation of the samples maintain the biocompatibility of the materials for the pristine polymer, but can lead to cytotoxic effects when the magnetic CFO nanoparticles are exposed, being therefore needed, for magnetoactive applications, to substitute them by biocompatible ferrites, such as an iron oxide (Fe3O4).application/pdfporMorphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applicationsAmaro, LuisCorreia, Daniela M.Martins, Pedro Manuel AbreuBotelho, GabrielaCarabineiro, Sónia A. C.Ribeiro, Clarisse Marta OliveiraLanceros-Méndez, S.HostingInstitutionOrganizationalRepositóriUM - Universidade do Minhoe-mailmailto:repositorium@usdb.uminho.ptrepositorium@usdb.uminho.ptCITATIONAmaro, Luis; Correia, Daniela M.; Martins, Pedro M.; Botelho, Gabriela; Carabineiro, Sónia A. C.; Ribeiro, Clarisse; Lanceros-Mendez, Senentxu, Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications. Polymers, 12(4), 953, 2020.ISSNIsPartOf2073-4360EISSNIsPartOf2073-4360DOIIsPartOf10.3390/polym120409532020-04-162020-04-16T00:00:00ZHandlehttps://hdl.handle.net/1822/65104http://purl.org/coar/access_right/c_abf2open accesspiezoelectric materialspoly(hydroxybutyrate-co-hydroxyvalerate)hydrolytic degradationtissue engineering3336634 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2020-04-16http://creativecommons.org/licenses/by/4.0/openAccesshttp://purl.org/coar/access_right/c_abf2application/pdfhttps://repositorium.uminho.pt/bitstreams/4e905e87-a4f5-487b-9f14-43d642e23704/download |
| spellingShingle | Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications Amaro, Luis piezoelectric materials poly(hydroxybutyrate-co-hydroxyvalerate) hydrolytic degradation tissue engineering |
| status | SINGLETON |
| subject.fl_str_mv | piezoelectric materials poly(hydroxybutyrate-co-hydroxyvalerate) hydrolytic degradation tissue engineering |
| title | Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications |
| title_full | Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications |
| title_fullStr | Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications |
| title_full_unstemmed | Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications |
| title_short | Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications |
| title_sort | Morphology dependence degradation of electro- and magnetoactive poly(3-hydroxybutyrate-co-hydroxyvalerate) for tissue engineering applications |
| topic | piezoelectric materials poly(hydroxybutyrate-co-hydroxyvalerate) hydrolytic degradation tissue engineering |
| topic_facet | piezoelectric materials poly(hydroxybutyrate-co-hydroxyvalerate) hydrolytic degradation tissue engineering |
| url | https://hdl.handle.net/1822/65104 |
| visible | 1 |
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