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Control of T cell effector functions by miRNAs

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Resumo:The differentiation of effector T cells is a tightly regulated process that relies on the selective expression of lineage-defining master regulators that orchestrate unique transcriptional programs, including the production of distinct sets of effector cytokines. miRNAs are post-transcriptional regulators that are now viewed as critical players in these gene expression networks and help defining cell identity and function. This review summarises the role of individual miRNAs in the regulation of the differentiation of effector T cell subsets, including CD4+ T helper cells, cytotoxic CD8+ T cells and innate-like NKT cells. Moreover, we refer to miRNAs that have been identified to affect simultaneously two or more effector T cell populations, impacting on the balance between effector T cells in vivo, thus constituting potential biomarkers or targets for therapies aiming at boosting immunity or controlling autoimmunity.
Autores principais:Inácio, Daniel P.
Outros Autores:Amado, Tiago; Silva-Santos, Bruno; Gomes, Anita Quintal
Assunto:miRNAs T cell differentiation Effector T cells T cell regulation
Ano:2018
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso restrito
Instituição associada:Universidade Politécnica de Lisboa
Idioma:inglês
Origem:Repositório Científico da Universidade Politécnica de Lisboa

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