Publicação
Persistence with medical glaucoma therapy in newly diagnosed patients
| Resumo: | Background: Monotherapy, age, and side effects are significant risk factors for the discontinuation of antiglaucoma therapy. Long-term therapy persistence is crucial for slowing disease progression and preventing irreversible blindness. Therefore, it is essential to identify patients at higher risk of discontinuation. In this study, we aimed to evaluate the real-world persistence of antiglaucoma therapy in patients diagnosed with glaucoma in the primary healthcare units of the Lisbon and Tagus Valley regions. Methods: We conducted a retrospective longitudinal study by collecting data from the prescription records of new antiglaucoma drug users diagnosed with glaucoma between 2012 and 2013 in the Primary Health Care Units of the Lisbon and Tagus Valley Region. These patients were followed over 3 years. Therapy persistence was measured as the proportion of patients remaining on any antiglaucoma drug, regardless of any modifications or switching of drugs over time. Persistence was assessed at three time points: the end of the first, second, and third years of the observation period. Results: A total of 2138 patients treated using new antiglaucoma drugs (867 [40.6%] male patients; 1271 [59.4%] female patients) were included in the study. Over the observation period, the overall persistence rate decreased from 91.9% (n = 1965) in the first year to 67.3% (n = 1439) in the third year. Older patients (≥ 65 years) showed higher persistence rates, although there was a decrease over the 3-year follow-up period (from 1481 [92.7%] to 1124 [70.4%]). Additionally, participants initially treated with monotherapy showed higher persistence rates, ranging from 92.4% (n = 1186) in the first year to 70.2% (n = 901) in the third year. Conclusions: The findings highlight the importance of patient follow-up over time, as almost one in three new antiglaucoma therapy users completely discontinued treatment, potentially risking disease progression. This could be mitigated with proper use of these drugs. Further studies should utilize recent health information systems to explore the impact of medication adherence and persistence on the functional and structural outcomes in patients with glaucoma. |
|---|---|
| Autores principais: | Menino, Joana |
| Outros Autores: | Camacho, Pedro; Coelho, André |
| Assunto: | Ophthalmology Glaucoma Anti-glaucoma therapy Drug persistence Therapy persistence Drug discontinuation Medication non-adherence UIDB/05608/2020 UIDP/05608/2020 |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Politécnica de Lisboa |
| Idioma: | inglês |
| Origem: | Repositório Científico da Universidade Politécnica de Lisboa |
| _version_ | 1880398297210814464 |
|---|---|
| author | Menino, Joana |
| author2 | Camacho, Pedro Coelho, André |
| author2_role | author author |
| author_facet | Menino, Joana Camacho, Pedro Coelho, André |
| author_role | author |
| contributor_name_str_mv | RCIPL |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Menino, Joana\"},{\"Person.name\":\"Camacho, Pedro\",\"Person.identifier.cienciaID\":\"271F-B4E1-014E\",\"Person.identifier.orcid\":\"0000-0002-2986-5652\"},{\"Person.name\":\"Coelho, André\",\"Person.identifier.cienciaID\":\"291E-1AC6-86FA\",\"Person.identifier.orcid\":\"0000-0003-1872-8131\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | RCIPL |
| datacite.creators.creator.creatorName.fl_str_mv | Menino, Joana Camacho, Pedro Coelho, André |
| datacite.date.Accepted.fl_str_mv | 2024-08-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-08-28T11:14:48Z |
| datacite.date.embargoed.fl_str_mv | 2024-08-28T11:14:48Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Ophthalmology Glaucoma Anti-glaucoma therapy Drug persistence Therapy persistence Drug discontinuation Medication non-adherence UIDB/05608/2020 UIDP/05608/2020 |
| datacite.titles.title.fl_str_mv | Persistence with medical glaucoma therapy in newly diagnosed patients |
| dc.contributor.none.fl_str_mv | RCIPL |
| dc.creator.none.fl_str_mv | Menino, Joana Camacho, Pedro Coelho, André |
| dc.date.Accepted.fl_str_mv | 2024-08-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-08-28T11:14:48Z |
| dc.date.embargoed.fl_str_mv | 2024-08-28T11:14:48Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.21/17631 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | International Virtual Ophthalmic Research Center |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Ophthalmology Glaucoma Anti-glaucoma therapy Drug persistence Therapy persistence Drug discontinuation Medication non-adherence UIDB/05608/2020 UIDP/05608/2020 |
| dc.title.fl_str_mv | Persistence with medical glaucoma therapy in newly diagnosed patients |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Background: Monotherapy, age, and side effects are significant risk factors for the discontinuation of antiglaucoma therapy. Long-term therapy persistence is crucial for slowing disease progression and preventing irreversible blindness. Therefore, it is essential to identify patients at higher risk of discontinuation. In this study, we aimed to evaluate the real-world persistence of antiglaucoma therapy in patients diagnosed with glaucoma in the primary healthcare units of the Lisbon and Tagus Valley regions. Methods: We conducted a retrospective longitudinal study by collecting data from the prescription records of new antiglaucoma drug users diagnosed with glaucoma between 2012 and 2013 in the Primary Health Care Units of the Lisbon and Tagus Valley Region. These patients were followed over 3 years. Therapy persistence was measured as the proportion of patients remaining on any antiglaucoma drug, regardless of any modifications or switching of drugs over time. Persistence was assessed at three time points: the end of the first, second, and third years of the observation period. Results: A total of 2138 patients treated using new antiglaucoma drugs (867 [40.6%] male patients; 1271 [59.4%] female patients) were included in the study. Over the observation period, the overall persistence rate decreased from 91.9% (n = 1965) in the first year to 67.3% (n = 1439) in the third year. Older patients (≥ 65 years) showed higher persistence rates, although there was a decrease over the 3-year follow-up period (from 1481 [92.7%] to 1124 [70.4%]). Additionally, participants initially treated with monotherapy showed higher persistence rates, ranging from 92.4% (n = 1186) in the first year to 70.2% (n = 901) in the third year. Conclusions: The findings highlight the importance of patient follow-up over time, as almost one in three new antiglaucoma therapy users completely discontinued treatment, potentially risking disease progression. This could be mitigated with proper use of these drugs. Further studies should utilize recent health information systems to explore the impact of medication adherence and persistence on the functional and structural outcomes in patients with glaucoma. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://repositorio.ipl.pt/bitstreams/c65fef59-b844-46e3-884f-f3588eac780f/download |
| id | ripl_1145a11c2ffa4e3308286df9ff11ec9e |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.21/17631 |
| inst_facet_str | urn:organizationAcronym:ipl{{{_:::_}}}Universidade Politécnica de Lisboa |
| instacron_str | ipl |
| institution | Universidade Politécnica de Lisboa |
| instname_str | Universidade Politécnica de Lisboa |
| language | eng |
| network_acronym_str | ripl |
| network_name_str | Repositório Científico da Universidade Politécnica de Lisboa |
| oai_identifier_str | oai:repositorio.ipl.pt:10400.21/17631 |
| organization_str_mv | urn:organizationAcronym:ipl |
| person_str_mv | Menino, Joana Camacho, Pedro Camacho, Pedro https://www.ciencia-id.pt/271F-B4E1-014E 271F-B4E1-014E http://orcid.org/0000-0002-2986-5652 0000-0002-2986-5652 Coelho, André Coelho, André https://www.ciencia-id.pt/291E-1AC6-86FA 291E-1AC6-86FA http://orcid.org/0000-0003-1872-8131 0000-0003-1872-8131 |
| publishDate | 2024 |
| publisher.none.fl_str_mv | International Virtual Ophthalmic Research Center |
| repo_facet_str | urn:repositoryAcronym:ripl{{{_:::_}}}Repositório Científico da Universidade Politécnica de Lisboa |
| reponame_str | Repositório Científico da Universidade Politécnica de Lisboa |
| repository_id_str | urn:repositoryAcronym:ripl |
| service_str_mv | urn:repositoryAcronym:ripl |
| spelling | engInternational Virtual Ophthalmic Research Centerpt_PTBackground: Monotherapy, age, and side effects are significant risk factors for the discontinuation of antiglaucoma therapy. Long-term therapy persistence is crucial for slowing disease progression and preventing irreversible blindness. Therefore, it is essential to identify patients at higher risk of discontinuation. In this study, we aimed to evaluate the real-world persistence of antiglaucoma therapy in patients diagnosed with glaucoma in the primary healthcare units of the Lisbon and Tagus Valley regions. Methods: We conducted a retrospective longitudinal study by collecting data from the prescription records of new antiglaucoma drug users diagnosed with glaucoma between 2012 and 2013 in the Primary Health Care Units of the Lisbon and Tagus Valley Region. These patients were followed over 3 years. Therapy persistence was measured as the proportion of patients remaining on any antiglaucoma drug, regardless of any modifications or switching of drugs over time. Persistence was assessed at three time points: the end of the first, second, and third years of the observation period. Results: A total of 2138 patients treated using new antiglaucoma drugs (867 [40.6%] male patients; 1271 [59.4%] female patients) were included in the study. Over the observation period, the overall persistence rate decreased from 91.9% (n = 1965) in the first year to 67.3% (n = 1439) in the third year. Older patients (≥ 65 years) showed higher persistence rates, although there was a decrease over the 3-year follow-up period (from 1481 [92.7%] to 1124 [70.4%]). Additionally, participants initially treated with monotherapy showed higher persistence rates, ranging from 92.4% (n = 1186) in the first year to 70.2% (n = 901) in the third year. Conclusions: The findings highlight the importance of patient follow-up over time, as almost one in three new antiglaucoma therapy users completely discontinued treatment, potentially risking disease progression. This could be mitigated with proper use of these drugs. Further studies should utilize recent health information systems to explore the impact of medication adherence and persistence on the functional and structural outcomes in patients with glaucoma.application/pdfpt_PTPersistence with medical glaucoma therapy in newly diagnosed patientsMenino, JoanaPersonalCamacho, PedroDSpacehttp://dspace.org/items/c41e9c52-157e-4375-8005-b609cfc374e7DSpacehttp://dspace.org/items/c41e9c52-157e-4375-8005-b609cfc374e7CamachoPedroCiência IDhttps://www.ciencia-id.pt271F-B4E1-014EORCIDhttp://orcid.org0000-0002-2986-5652PersonalCoelho, AndréDSpacehttp://dspace.org/items/e00e9fd8-697d-4e70-acd3-e5a5169360edDSpacehttp://dspace.org/items/e00e9fd8-697d-4e70-acd3-e5a5169360edFerreira Ramos CoelhoAndré FilipeCiência IDhttps://www.ciencia-id.pt291E-1AC6-86FAORCIDhttp://orcid.org0000-0003-1872-8131HostingInstitutionOrganizationalRCIPLe-mailmailto:rcaap@sp.ipl.ptrcaap@sp.ipl.ptDOIIsPartOf10.51329/mehdiophthal14952024-08-28T11:14:48Z2024-082024-08-01T00:00:00ZHandlehttp://hdl.handle.net/10400.21/17631http://purl.org/coar/access_right/c_abf2open accessOphthalmologyGlaucomaAnti-glaucoma therapyDrug persistenceTherapy persistenceDrug discontinuationMedication non-adherenceUIDB/05608/2020UIDP/05608/20201307710 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2024-08http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.ipl.pt/bitstreams/c65fef59-b844-46e3-884f-f3588eac780f/downloadMedical Hypothesis Discovery and Innovation in Ophthalmology1326369 |
| spellingShingle | Persistence with medical glaucoma therapy in newly diagnosed patients Menino, Joana Ophthalmology Glaucoma Anti-glaucoma therapy Drug persistence Therapy persistence Drug discontinuation Medication non-adherence UIDB/05608/2020 UIDP/05608/2020 |
| status | SINGLETON |
| subject.fl_str_mv | Ophthalmology Glaucoma Anti-glaucoma therapy Drug persistence Therapy persistence Drug discontinuation Medication non-adherence UIDB/05608/2020 UIDP/05608/2020 |
| title | Persistence with medical glaucoma therapy in newly diagnosed patients |
| title_full | Persistence with medical glaucoma therapy in newly diagnosed patients |
| title_fullStr | Persistence with medical glaucoma therapy in newly diagnosed patients |
| title_full_unstemmed | Persistence with medical glaucoma therapy in newly diagnosed patients |
| title_short | Persistence with medical glaucoma therapy in newly diagnosed patients |
| title_sort | Persistence with medical glaucoma therapy in newly diagnosed patients |
| topic | Ophthalmology Glaucoma Anti-glaucoma therapy Drug persistence Therapy persistence Drug discontinuation Medication non-adherence UIDB/05608/2020 UIDP/05608/2020 |
| topic_facet | Ophthalmology Glaucoma Anti-glaucoma therapy Drug persistence Therapy persistence Drug discontinuation Medication non-adherence UIDB/05608/2020 UIDP/05608/2020 |
| url | http://hdl.handle.net/10400.21/17631 |
| visible | 1 |
Atividades financiadas
Não foram encontrados projetos financiados.