Publicação
A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications
| Resumo: | Three-dimensional (3D) bioprinting is an innovative technology in the biomedical field, allowing the fabrication of living constructs through an approach of layer-by-layer deposition of cell-laden inks, the so-called bioinks. An ideal bioink should possess proper mechanical, rheological, chemical, and biological characteristics to ensure high cell viability and the production of tissue constructs with dimensional stability and shape fidelity. Among the several types of bioinks, hydrogels are extremely appealing as they have many similarities with the extracellular matrix, providing a highly hydrated environment for cell proliferation and tunability in terms of mechanical and rheological properties. Hydrogels derived from natural polymers, and polysaccharides, in particular, are an excellent platform to mimic the extracellular matrix, given their low cytotoxicity, high hydrophilicity, and diversity of structures. In fact, polysaccharide-based hydrogels are trendy materials for 3D bioprinting since they are abundant and combine adequate physicochemical and biomimetic features for the development of novel bioinks. Thus, this review portrays the most relevant advances in polysaccharide-based hydrogel bioinks for 3D bioprinting, focusing on the last five years, with emphasis on their properties, advantages, and limitations, considering polysaccharide families classified according to their source, namely from seaweed, higher plants, microbial, and animal (particularly crustaceans) origin. |
|---|---|
| Autores principais: | Teixeira, Maria C. |
| Outros Autores: | Lameirinhas, Nicole S.; Carvalho, João P. F.; Silvestre, Armando J. D.; Vilela, Carla; Freire, Carmen S. R. |
| Assunto: | 3D bioprinting Bioinks Cell-laden constructs Hydrogels Polysaccharides |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade de Aveiro |
| Idioma: | inglês |
| Origem: | RIA - Repositório Institucional da Universidade de Aveiro |
| _version_ | 1877769249474215936 |
|---|---|
| author | Teixeira, Maria C. |
| author2 | Lameirinhas, Nicole S. Carvalho, João P. F. Silvestre, Armando J. D. Vilela, Carla Freire, Carmen S. R. |
| author2_role | author author author author author |
| author_facet | Teixeira, Maria C. Lameirinhas, Nicole S. Carvalho, João P. F. Silvestre, Armando J. D. Vilela, Carla Freire, Carmen S. R. |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Teixeira, Maria C.\"},{\"Person.name\":\"Lameirinhas, Nicole S.\"},{\"Person.name\":\"Carvalho, João P. F.\"},{\"Person.name\":\"Silvestre, Armando J. D.\"},{\"Person.name\":\"Vilela, Carla\"},{\"Person.name\":\"Freire, Carmen S. R.\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Teixeira, Maria C. Lameirinhas, Nicole S. Carvalho, João P. F. Silvestre, Armando J. D. Vilela, Carla Freire, Carmen S. R. |
| datacite.date.Accepted.fl_str_mv | 2022-06-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-01-25T16:54:07Z |
| datacite.date.embargoed.fl_str_mv | 2023-01-25T16:54:07Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | 3D bioprinting Bioinks Cell-laden constructs Hydrogels Polysaccharides |
| datacite.titles.title.fl_str_mv | A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications |
| dc.creator.none.fl_str_mv | Teixeira, Maria C. Lameirinhas, Nicole S. Carvalho, João P. F. Silvestre, Armando J. D. Vilela, Carla Freire, Carmen S. R. |
| dc.date.Accepted.fl_str_mv | 2022-06-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-01-25T16:54:07Z |
| dc.date.embargoed.fl_str_mv | 2023-01-25T16:54:07Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10773/36005 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | 3D bioprinting Bioinks Cell-laden constructs Hydrogels Polysaccharides |
| dc.title.fl_str_mv | A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Three-dimensional (3D) bioprinting is an innovative technology in the biomedical field, allowing the fabrication of living constructs through an approach of layer-by-layer deposition of cell-laden inks, the so-called bioinks. An ideal bioink should possess proper mechanical, rheological, chemical, and biological characteristics to ensure high cell viability and the production of tissue constructs with dimensional stability and shape fidelity. Among the several types of bioinks, hydrogels are extremely appealing as they have many similarities with the extracellular matrix, providing a highly hydrated environment for cell proliferation and tunability in terms of mechanical and rheological properties. Hydrogels derived from natural polymers, and polysaccharides, in particular, are an excellent platform to mimic the extracellular matrix, given their low cytotoxicity, high hydrophilicity, and diversity of structures. In fact, polysaccharide-based hydrogels are trendy materials for 3D bioprinting since they are abundant and combine adequate physicochemical and biomimetic features for the development of novel bioinks. Thus, this review portrays the most relevant advances in polysaccharide-based hydrogel bioinks for 3D bioprinting, focusing on the last five years, with emphasis on their properties, advantages, and limitations, considering polysaccharide families classified according to their source, namely from seaweed, higher plants, microbial, and animal (particularly crustaceans) origin. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | ria_cd6d8ec62be96e61353a1bbbdcd6fe80 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10773/36005 |
| inst_facet_str | urn:organizationAcronym:ua{{{_:::_}}}Universidade de Aveiro |
| instacron_str | ua |
| institution | Universidade de Aveiro |
| instname_str | Universidade de Aveiro |
| language | eng |
| network_acronym_str | ria |
| network_name_str | RIA - Repositório Institucional da Universidade de Aveiro |
| oai_identifier_str | oai:ria.ua.pt:10773/36005 |
| organization_str_mv | urn:organizationAcronym:ua |
| person_str_mv | Teixeira, Maria C. Lameirinhas, Nicole S. Carvalho, João P. F. Silvestre, Armando J. D. Vilela, Carla Freire, Carmen S. R. |
| publishDate | 2022 |
| publisher.none.fl_str_mv | MDPI |
| repo_facet_str | urn:repositoryAcronym:ria{{{_:::_}}}RIA - Repositório Institucional da Universidade de Aveiro |
| reponame_str | RIA - Repositório Institucional da Universidade de Aveiro |
| repository_id_str | urn:repositoryAcronym:ria |
| service_str_mv | urn:repositoryAcronym:ria |
| spelling | pt_PTThree-dimensional (3D) bioprinting is an innovative technology in the biomedical field, allowing the fabrication of living constructs through an approach of layer-by-layer deposition of cell-laden inks, the so-called bioinks. An ideal bioink should possess proper mechanical, rheological, chemical, and biological characteristics to ensure high cell viability and the production of tissue constructs with dimensional stability and shape fidelity. Among the several types of bioinks, hydrogels are extremely appealing as they have many similarities with the extracellular matrix, providing a highly hydrated environment for cell proliferation and tunability in terms of mechanical and rheological properties. Hydrogels derived from natural polymers, and polysaccharides, in particular, are an excellent platform to mimic the extracellular matrix, given their low cytotoxicity, high hydrophilicity, and diversity of structures. In fact, polysaccharide-based hydrogels are trendy materials for 3D bioprinting since they are abundant and combine adequate physicochemical and biomimetic features for the development of novel bioinks. Thus, this review portrays the most relevant advances in polysaccharide-based hydrogel bioinks for 3D bioprinting, focusing on the last five years, with emphasis on their properties, advantages, and limitations, considering polysaccharide families classified according to their source, namely from seaweed, higher plants, microbial, and animal (particularly crustaceans) origin.application/pdfengMDPIpt_PTA guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applicationsTeixeira, Maria C.Lameirinhas, Nicole S.Carvalho, João P. F.Silvestre, Armando J. D.Vilela, CarlaFreire, Carmen S. R.Handlehttp://hdl.handle.net/10773/36005ISSNIsPartOf1661-6596DOIIsPartOf10.3390/ijms231265642023-01-25T16:54:07Z2022-06-01T00:00:00Z2022-06http://purl.org/coar/access_right/c_abf2open accesspt_PT3D bioprintingpt_PTBioinkspt_PTCell-laden constructspt_PTHydrogelspt_PTPolysaccharides3192481 byteshttp://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://ria.ua.pt/bitstream/10773/36005/1/ijms-23-06564-v2.pdfliteraturehttp://purl.org/coar/resource_type/c_6501journal article |
| spellingShingle | A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications Teixeira, Maria C. 3D bioprinting Bioinks Cell-laden constructs Hydrogels Polysaccharides |
| status | SINGLETON |
| subject.fl_str_mv | 3D bioprinting Bioinks Cell-laden constructs Hydrogels Polysaccharides |
| title | A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications |
| title_full | A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications |
| title_fullStr | A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications |
| title_full_unstemmed | A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications |
| title_short | A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications |
| title_sort | A guide to polysaccharide-based hydrogel bioinks for 3D bioprinting applications |
| topic | 3D bioprinting Bioinks Cell-laden constructs Hydrogels Polysaccharides |
| topic_facet | 3D bioprinting Bioinks Cell-laden constructs Hydrogels Polysaccharides |
| url | http://hdl.handle.net/10773/36005 |
| visible | 1 |
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