Publicação
Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study
| Resumo: | The aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-phenoxybenzoic acid (3-PBA) and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. We also aimed to compare exposure in summer with exposure in winter. Pregnant women attending ultrasound scans from April 2018 to April 2019 at a central hospital in Porto, Portugal, were invited to participate. Inclusion criteria were: gestational week between 10 and 13, confirmed fetal vitality, and a signature of informed consent. 3-PBA was measured in spot urine samples by gas chromatography with mass spectrometry (GC-MS). The median 3-PBA concentration was 0.263 (0.167; 0.458) μg/g creatinine (n = 145). 3-PBA excretion was negatively associated with maternal pre-pregnancy body mass index (BMI) (p = 0.049), and it was higher during the summer when compared to winter (p < 0.001). The frequency of fish or yogurt consumption was associated positively with 3-PBA excretion, particularly during the winter (p = 0.002 and p = 0.015, respectively), when environmental exposure is low. Moreover, 3-PBA was associated with levothyroxine use (p = 0.01), a proxy for hypothyroidism, which could be due to a putative 3-PBA—thyroid hormone antagonistic effect. 3-PBA levels were not associated with the anthropometric measures of the newborn. In conclusion, pregnant women living in Portugal are exposed to 3-PBA, particularly during summer, and this exposure may be associated with maternal clinical features. |
|---|---|
| Autores principais: | Guimarães, Juliana |
| Outros Autores: | Bracchi, Isabella; Pinheiro, Cátia; Moreira, Nara Xavier; Coelho, Cláudia Matta; Pestana, Diogo; Prucha, Maria do Carmo; Martins, Cristina; Domingues, Valentina F.; Delerue-Matos, Cristina; Dias, Cláudia C.; Azevedo, Luís Filipe R.; Calhau, Conceição; Leite, João Costa; Ramalho, Carla; Keating, Elisa; Fernandes, Virgínia Cruz |
| Assunto: | 3-PBA Pyrethroid pesticide Pregnancy Newborn Anthropometry |
| Ano: | 2023 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico do Porto |
| Idioma: | inglês |
| Origem: | Repositório Científico do Instituto Politécnico do Porto |
| _version_ | 1877953024436994048 |
|---|---|
| author | Guimarães, Juliana |
| author2 | Bracchi, Isabella Pinheiro, Cátia Moreira, Nara Xavier Coelho, Cláudia Matta Pestana, Diogo Prucha, Maria do Carmo Martins, Cristina Domingues, Valentina F. Delerue-Matos, Cristina Dias, Cláudia C. Azevedo, Luís Filipe R. Calhau, Conceição Leite, João Costa Ramalho, Carla Keating, Elisa Fernandes, Virgínia Cruz |
| author2_role | author author author author author author author author author author author author author author author author |
| author_facet | Guimarães, Juliana Bracchi, Isabella Pinheiro, Cátia Moreira, Nara Xavier Coelho, Cláudia Matta Pestana, Diogo Prucha, Maria do Carmo Martins, Cristina Domingues, Valentina F. Delerue-Matos, Cristina Dias, Cláudia C. Azevedo, Luís Filipe R. Calhau, Conceição Leite, João Costa Ramalho, Carla Keating, Elisa Fernandes, Virgínia Cruz |
| author_role | author |
| contributor_name_str_mv | REPOSITÓRIO P.PORTO |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Guimarães, Juliana\"},{\"Person.name\":\"Bracchi, Isabella\"},{\"Person.name\":\"Pinheiro, Cátia\"},{\"Person.name\":\"Moreira, Nara Xavier\"},{\"Person.name\":\"Coelho, Cláudia Matta\"},{\"Person.name\":\"Pestana, Diogo\"},{\"Person.name\":\"Prucha, Maria do Carmo\"},{\"Person.name\":\"Martins, Cristina\"},{\"Person.name\":\"Domingues, Valentina F.\",\"Person.identifier.cienciaID\":\"4E16-791D-6664\",\"Person.identifier.orcid\":\"0000-0003-3472-849X\"},{\"Person.name\":\"Delerue-Matos, Cristina\",\"Person.identifier.cienciaID\":\"9A1A-43FB-5C27\",\"Person.identifier.orcid\":\"0000-0002-3924-776X\",\"Person.identifier.researcherID\":\"D-4990-2013\",\"Person.identifier.scopusAuthorID\":\"6603741848\"},{\"Person.name\":\"Dias, Cláudia C.\"},{\"Person.name\":\"Azevedo, Luís Filipe R.\"},{\"Person.name\":\"Calhau, Conceição\"},{\"Person.name\":\"Leite, João Costa\"},{\"Person.name\":\"Ramalho, Carla\"},{\"Person.name\":\"Keating, Elisa\"},{\"Person.name\":\"Fernandes, Virgínia Cruz\",\"Person.identifier.cienciaID\":\"5A16-3713-E0CE\",\"Person.identifier.orcid\":\"0000-0003-3979-7523\",\"Person.identifier.researcherID\":\"G-4985-2010\",\"Person.identifier.scopusAuthorID\":\"37045954500\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | REPOSITÓRIO P.PORTO |
| datacite.creators.creator.creatorName.fl_str_mv | Guimarães, Juliana Bracchi, Isabella Pinheiro, Cátia Moreira, Nara Xavier Coelho, Cláudia Matta Pestana, Diogo Prucha, Maria do Carmo Martins, Cristina Domingues, Valentina F. Delerue-Matos, Cristina Dias, Cláudia C. Azevedo, Luís Filipe R. Calhau, Conceição Leite, João Costa Ramalho, Carla Keating, Elisa Fernandes, Virgínia Cruz |
| datacite.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-03-15T10:40:15Z |
| datacite.date.embargoed.fl_str_mv | 2023-03-15T10:40:15Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | 3-PBA Pyrethroid pesticide Pregnancy Newborn Anthropometry |
| datacite.titles.title.fl_str_mv | Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study |
| dc.contributor.none.fl_str_mv | REPOSITÓRIO P.PORTO |
| dc.creator.none.fl_str_mv | Guimarães, Juliana Bracchi, Isabella Pinheiro, Cátia Moreira, Nara Xavier Coelho, Cláudia Matta Pestana, Diogo Prucha, Maria do Carmo Martins, Cristina Domingues, Valentina F. Delerue-Matos, Cristina Dias, Cláudia C. Azevedo, Luís Filipe R. Calhau, Conceição Leite, João Costa Ramalho, Carla Keating, Elisa Fernandes, Virgínia Cruz |
| dc.date.Accepted.fl_str_mv | 2023-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-03-15T10:40:15Z |
| dc.date.embargoed.fl_str_mv | 2023-03-15T10:40:15Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.22/22495 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | MDPI |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | 3-PBA Pyrethroid pesticide Pregnancy Newborn Anthropometry |
| dc.title.fl_str_mv | Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | The aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-phenoxybenzoic acid (3-PBA) and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. We also aimed to compare exposure in summer with exposure in winter. Pregnant women attending ultrasound scans from April 2018 to April 2019 at a central hospital in Porto, Portugal, were invited to participate. Inclusion criteria were: gestational week between 10 and 13, confirmed fetal vitality, and a signature of informed consent. 3-PBA was measured in spot urine samples by gas chromatography with mass spectrometry (GC-MS). The median 3-PBA concentration was 0.263 (0.167; 0.458) μg/g creatinine (n = 145). 3-PBA excretion was negatively associated with maternal pre-pregnancy body mass index (BMI) (p = 0.049), and it was higher during the summer when compared to winter (p < 0.001). The frequency of fish or yogurt consumption was associated positively with 3-PBA excretion, particularly during the winter (p = 0.002 and p = 0.015, respectively), when environmental exposure is low. Moreover, 3-PBA was associated with levothyroxine use (p = 0.01), a proxy for hypothyroidism, which could be due to a putative 3-PBA—thyroid hormone antagonistic effect. 3-PBA levels were not associated with the anthropometric measures of the newborn. In conclusion, pregnant women living in Portugal are exposed to 3-PBA, particularly during summer, and this exposure may be associated with maternal clinical features. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://recipp.ipp.pt/bitstreams/31fa49ee-912e-4755-abde-e1546429c481/download |
| funder_facet_str_mv | FCT{{{_:::_}}}Fundação para a Ciência e a Tecnologia FCT{{{_:::_}}}Fundação para a Ciência e a Tecnologia FCT{{{_:::_}}}Fundação para a Ciência e a Tecnologia FCT{{{_:::_}}}Fundação para a Ciência e a Tecnologia |
| funding.funder.alternateName_str_mv | FCT FCT FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.identifier_str_mv | UIDB/50006/2020 UIDP/50006/2020 SFRH/BPD/109153/2015 UI/BD/152087/2021 |
| funding.name_str_mv | 6817 - DCRRNI ID 6817 - DCRRNI ID POR_NORTE |
| funding_str_mv | UIDB/50006/2020 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT UIDP/50006/2020 info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT SFRH/BPD/109153/2015 info:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F109153%2F2015/PT UI/BD/152087/2021 info:eu-repo/grantAgreement/FCT//UI%2FBD%2F152087%2F2021/PT |
| id | recipp_bc8a65332f58239a8f5fdc7358ba7088 |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.22/22495 |
| inst_facet_str | urn:organizationAcronym:recipp{{{_:::_}}}Instituto Politécnico do Porto |
| instacron_str | recipp |
| institution | Instituto Politécnico do Porto |
| instname_str | Instituto Politécnico do Porto |
| language | eng |
| network_acronym_str | recipp |
| network_name_str | Repositório Científico do Instituto Politécnico do Porto |
| oai_identifier_str | oai:recipp.ipp.pt:10400.22/22495 |
| organization_str_mv | urn:organizationAcronym:recipp |
| person_str_mv | Guimarães, Juliana Bracchi, Isabella Pinheiro, Cátia Moreira, Nara Xavier Coelho, Cláudia Matta Pestana, Diogo Prucha, Maria do Carmo Martins, Cristina Domingues, Valentina F. Domingues, Valentina F. https://www.ciencia-id.pt/4E16-791D-6664 4E16-791D-6664 http://orcid.org/0000-0003-3472-849X 0000-0003-3472-849X Delerue-Matos, Cristina Delerue-Matos, Cristina https://www.ciencia-id.pt/9A1A-43FB-5C27 9A1A-43FB-5C27 http://orcid.org/0000-0002-3924-776X 0000-0002-3924-776X Dias, Cláudia C. Azevedo, Luís Filipe R. Calhau, Conceição Leite, João Costa Ramalho, Carla Keating, Elisa Fernandes, Virgínia Cruz Fernandes, Virgínia Cruz https://www.ciencia-id.pt/5A16-3713-E0CE 5A16-3713-E0CE http://orcid.org/0000-0003-3979-7523 0000-0003-3979-7523 |
| publishDate | 2023 |
| publisher.none.fl_str_mv | MDPI |
| repo_facet_str | urn:repositoryAcronym:recipp{{{_:::_}}}Repositório Científico do Instituto Politécnico do Porto |
| reponame_str | Repositório Científico do Instituto Politécnico do Porto |
| repository_id_str | urn:repositoryAcronym:recipp |
| service_str_mv | urn:repositoryAcronym:recipp |
| spelling | engMDPIpt_PTThe aims of this study were to characterize the exposure of pregnant women living in Portugal to 3-phenoxybenzoic acid (3-PBA) and to evaluate the association of this exposure with maternal outcomes and newborn anthropometric measures. We also aimed to compare exposure in summer with exposure in winter. Pregnant women attending ultrasound scans from April 2018 to April 2019 at a central hospital in Porto, Portugal, were invited to participate. Inclusion criteria were: gestational week between 10 and 13, confirmed fetal vitality, and a signature of informed consent. 3-PBA was measured in spot urine samples by gas chromatography with mass spectrometry (GC-MS). The median 3-PBA concentration was 0.263 (0.167; 0.458) μg/g creatinine (n = 145). 3-PBA excretion was negatively associated with maternal pre-pregnancy body mass index (BMI) (p = 0.049), and it was higher during the summer when compared to winter (p < 0.001). The frequency of fish or yogurt consumption was associated positively with 3-PBA excretion, particularly during the winter (p = 0.002 and p = 0.015, respectively), when environmental exposure is low. Moreover, 3-PBA was associated with levothyroxine use (p = 0.01), a proxy for hypothyroidism, which could be due to a putative 3-PBA—thyroid hormone antagonistic effect. 3-PBA levels were not associated with the anthropometric measures of the newborn. In conclusion, pregnant women living in Portugal are exposed to 3-PBA, particularly during summer, and this exposure may be associated with maternal clinical features.application/pdfpt_PTAssociation of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort StudyGuimarães, JulianaBracchi, IsabellaPinheiro, CátiaMoreira, Nara XavierCoelho, Cláudia MattaPestana, DiogoPrucha, Maria do CarmoMartins, CristinaPersonalDomingues, Valentina F.DSpacehttp://dspace.org/items/be653ab6-34ec-4329-972a-eee990a7ec66DSpacehttp://dspace.org/items/be653ab6-34ec-4329-972a-eee990a7ec66DominguesValentina Maria FernandesCiência IDhttps://www.ciencia-id.pt4E16-791D-6664ORCIDhttp://orcid.org0000-0003-3472-849XPersonalDelerue-Matos, CristinaDSpacehttp://dspace.org/items/09f6a7bd-2f15-42b0-adc5-04bd22210519DSpacehttp://dspace.org/items/09f6a7bd-2f15-42b0-adc5-04bd22210519Delerue-MatosCristinaCiência IDhttps://www.ciencia-id.pt9A1A-43FB-5C27ORCIDhttp://orcid.org0000-0002-3924-776XResearcher IDhttps://www.researcherid.comD-4990-2013Scopus Author IDhttps://www.scopus.com6603741848Dias, Cláudia C.Azevedo, Luís Filipe R.Calhau, ConceiçãoLeite, João CostaRamalho, CarlaKeating, ElisaPersonalFernandes, Virgínia CruzDSpacehttp://dspace.org/items/e30d74c3-1a3a-4e3e-ada0-5e79362cdd6eDSpacehttp://dspace.org/items/e30d74c3-1a3a-4e3e-ada0-5e79362cdd6eFernandesVirgíniaCiência IDhttps://www.ciencia-id.pt5A16-3713-E0CEORCIDhttp://orcid.org0000-0003-3979-7523Researcher IDhttps://www.researcherid.comG-4985-2010Scopus Author IDhttps://www.scopus.com37045954500HostingInstitutionOrganizationalREPOSITÓRIO P.PORTOe-mailmailto:recipp@sc.ipp.ptrecipp@sc.ipp.ptISSNIsPartOf2305-6304DOIIsPartOf10.3390/toxics110201252023-03-15T10:40:15Z20232023-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.22/22495http://purl.org/coar/access_right/c_abf2open access3-PBAPyrethroid pesticidePregnancyNewbornAnthropometry1228614 bytesFundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processesinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PTUIDB/50006/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processesinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PTUIDP/50006/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruitsinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F109153%2F2015/PTSFRH/BPD/109153/2015POR_NORTECrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaEnvironmental pollutants in pregnancy: assessment of exposure and impact in the first 1000 days of lifeinfo:eu-repo/grantAgreement/FCT//UI%2FBD%2F152087%2F2021/PTUI/BD/152087/2021Crossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2023http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://recipp.ipp.pt/bitstreams/31fa49ee-912e-4755-abde-e1546429c481/downloadToxics112125 |
| spellingShingle | Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study Guimarães, Juliana 3-PBA Pyrethroid pesticide Pregnancy Newborn Anthropometry |
| status | SINGLETON |
| subject.fl_str_mv | 3-PBA Pyrethroid pesticide Pregnancy Newborn Anthropometry |
| title | Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study |
| title_full | Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study |
| title_fullStr | Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study |
| title_full_unstemmed | Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study |
| title_short | Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study |
| title_sort | Association of 3-Phenoxybenzoic Acid Exposure during Pregnancy with Maternal Outcomes and Newborn Anthropometric Measures: Results from the IoMum Cohort Study |
| topic | 3-PBA Pyrethroid pesticide Pregnancy Newborn Anthropometry |
| topic_facet | 3-PBA Pyrethroid pesticide Pregnancy Newborn Anthropometry |
| url | http://hdl.handle.net/10400.22/22495 |
| visible | 1 |