Publicação
Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts
| Resumo: | Neuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzymes involved in neurodegenerative etiology, namely in Alzheimer’s and Parkinson’s diseases, and against reactive oxygen and nitrogen species, all contributing factors to the progression of neurodegeneration. Results showed no significant enzyme inhibition but strong radical scavenging activities, particularly in the fourth fraction, extracted at the highest temperature (250 °C), highlighting their ability to retard oxidative and nitrosative stresses. At higher temperatures, fractions were composed of phenolic compounds and Maillard reaction products, a combination that contributed to their antioxidant activity and, consequently, their neuroprotective properties. All fractions were evaluated for the presence of iodine, 14 organochlorine and 7 organophosphorus pesticides, and pharmaceuticals used in Alzheimer’s and Parkinson’s diseases (14), psychiatric drugs (8), and metabolites (8). The fractions studied did not present any of the screened contaminants, and only fraction 1 of E. bicyclis should be used with caution due to iodine content. |
|---|---|
| Autores principais: | Gomes, Inês |
| Outros Autores: | Rodrigues, Helena; Rodrigues, Carla; Oliveira, Marta Marques; Paíga, Paula; Paiva, Alexandre; Simões, Pedro; Fernandes, Virgínia Cruz; Vieira, Mónica; Delerue-Matos, Cristina; Soares, Cristina; Grosso, Clara |
| Assunto: | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content |
| Ano: | 2022 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Instituto Politécnico do Porto |
| Idioma: | inglês |
| Origem: | Repositório Científico do Instituto Politécnico do Porto |
| _version_ | 1877953325964460032 |
|---|---|
| author | Gomes, Inês |
| author2 | Rodrigues, Helena Rodrigues, Carla Oliveira, Marta Marques Paíga, Paula Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Vieira, Mónica Delerue-Matos, Cristina Soares, Cristina Grosso, Clara |
| author2_role | author author author author author author author author author author author |
| author_facet | Gomes, Inês Rodrigues, Helena Rodrigues, Carla Oliveira, Marta Marques Paíga, Paula Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Vieira, Mónica Delerue-Matos, Cristina Soares, Cristina Grosso, Clara |
| author_role | author |
| contributor_name_str_mv | REPOSITÓRIO P.PORTO |
| country_str | PT |
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| datacite.contributors.contributor.contributorName.fl_str_mv | REPOSITÓRIO P.PORTO |
| datacite.creators.creator.creatorName.fl_str_mv | Gomes, Inês Rodrigues, Helena Rodrigues, Carla Oliveira, Marta Marques Paíga, Paula Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Vieira, Mónica Delerue-Matos, Cristina Soares, Cristina Grosso, Clara |
| datacite.date.Accepted.fl_str_mv | 2022-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-01-25T15:32:23Z |
| datacite.date.embargoed.fl_str_mv | 2023-01-25T15:32:23Z |
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| datacite.subjects.subject.fl_str_mv | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content |
| datacite.titles.title.fl_str_mv | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| dc.contributor.none.fl_str_mv | REPOSITÓRIO P.PORTO |
| dc.creator.none.fl_str_mv | Gomes, Inês Rodrigues, Helena Rodrigues, Carla Oliveira, Marta Marques Paíga, Paula Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Vieira, Mónica Delerue-Matos, Cristina Soares, Cristina Grosso, Clara |
| dc.date.Accepted.fl_str_mv | 2022-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-01-25T15:32:23Z |
| dc.date.embargoed.fl_str_mv | 2023-01-25T15:32:23Z |
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| dc.language.none.fl_str_mv | eng |
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| dc.subject.none.fl_str_mv | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content |
| dc.title.fl_str_mv | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Neuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzymes involved in neurodegenerative etiology, namely in Alzheimer’s and Parkinson’s diseases, and against reactive oxygen and nitrogen species, all contributing factors to the progression of neurodegeneration. Results showed no significant enzyme inhibition but strong radical scavenging activities, particularly in the fourth fraction, extracted at the highest temperature (250 °C), highlighting their ability to retard oxidative and nitrosative stresses. At higher temperatures, fractions were composed of phenolic compounds and Maillard reaction products, a combination that contributed to their antioxidant activity and, consequently, their neuroprotective properties. All fractions were evaluated for the presence of iodine, 14 organochlorine and 7 organophosphorus pesticides, and pharmaceuticals used in Alzheimer’s and Parkinson’s diseases (14), psychiatric drugs (8), and metabolites (8). The fractions studied did not present any of the screened contaminants, and only fraction 1 of E. bicyclis should be used with caution due to iodine content. |
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| person_str_mv | Gomes, Inês Gomes, Inês https://www.ciencia-id.pt/AF1C-E8F1-8D52 AF1C-E8F1-8D52 http://orcid.org/0000-0002-4288-8496 0000-0002-4288-8496 Rodrigues, Helena Rodrigues, Carla Oliveira, Marta Marques Oliveira, Marta Marques https://www.ciencia-id.pt/0A1C-A89D-641A 0A1C-A89D-641A http://orcid.org/0000-0003-4150-0151 0000-0003-4150-0151 Paíga, Paula Paíga, Paula https://www.ciencia-id.pt/331A-5D6A-D3C8 331A-5D6A-D3C8 http://orcid.org/0000-0002-9593-1355 0000-0002-9593-1355 Paiva, Alexandre Simões, Pedro Fernandes, Virgínia Cruz Fernandes, Virgínia Cruz https://www.ciencia-id.pt/5A16-3713-E0CE 5A16-3713-E0CE http://orcid.org/0000-0003-3979-7523 0000-0003-3979-7523 Vieira, Mónica Delerue-Matos, Cristina Delerue-Matos, Cristina https://www.ciencia-id.pt/9A1A-43FB-5C27 9A1A-43FB-5C27 http://orcid.org/0000-0002-3924-776X 0000-0002-3924-776X Soares, Cristina Soares, Cristina https://www.ciencia-id.pt/5016-4F99-C69D 5016-4F99-C69D http://orcid.org/0000-0003-0924-9681 0000-0003-0924-9681 Grosso, Clara Grosso, Clara https://www.ciencia-id.pt/711B-1170-4C32 711B-1170-4C32 http://orcid.org/0000-0002-2457-8267 0000-0002-2457-8267 |
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| spelling | engMDPIpt_PTNeuroprotection is a need that remains unmet in treating chronic neurodegenerative disorders, despite decades of extensive research. To find new neuroprotective compounds, extracts of Himanthalia elongata (L.) S.F.Gray and of Eisenia bicyclis (Kjellman) Setchell were obtained through subcritical water extraction applying a four-step temperature gradient. The fractions obtained were screened against brain enzymes involved in neurodegenerative etiology, namely in Alzheimer’s and Parkinson’s diseases, and against reactive oxygen and nitrogen species, all contributing factors to the progression of neurodegeneration. Results showed no significant enzyme inhibition but strong radical scavenging activities, particularly in the fourth fraction, extracted at the highest temperature (250 °C), highlighting their ability to retard oxidative and nitrosative stresses. At higher temperatures, fractions were composed of phenolic compounds and Maillard reaction products, a combination that contributed to their antioxidant activity and, consequently, their neuroprotective properties. All fractions were evaluated for the presence of iodine, 14 organochlorine and 7 organophosphorus pesticides, and pharmaceuticals used in Alzheimer’s and Parkinson’s diseases (14), psychiatric drugs (8), and metabolites (8). The fractions studied did not present any of the screened contaminants, and only fraction 1 of E. bicyclis should be used with caution due to iodine content.application/pdfpt_PTEvaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water ExtractsPersonalGomes, InêsDSpacehttp://dspace.org/items/6cdb014d-8c32-4a14-b201-ac34a7f4d7b6DSpacehttp://dspace.org/items/6cdb014d-8c32-4a14-b201-ac34a7f4d7b6GomesInêsCiência IDhttps://www.ciencia-id.ptAF1C-E8F1-8D52ORCIDhttp://orcid.org0000-0002-4288-8496Rodrigues, HelenaRodrigues, CarlaPersonalOliveira, Marta MarquesDSpacehttp://dspace.org/items/6a7785e0-082e-492f-8cff-17ee1f1fe7b4DSpacehttp://dspace.org/items/6a7785e0-082e-492f-8cff-17ee1f1fe7b4Marques de OliveiraMarta MadalenaCiência IDhttps://www.ciencia-id.pt0A1C-A89D-641AORCIDhttp://orcid.org0000-0003-4150-0151Scopus Author IDhttps://www.scopus.com57202841330PersonalPaíga, PaulaDSpacehttp://dspace.org/items/4a0677dc-0b54-4831-aa9a-4a73f0df911dDSpacehttp://dspace.org/items/4a0677dc-0b54-4831-aa9a-4a73f0df911dPaígaPaulaCiência IDhttps://www.ciencia-id.pt331A-5D6A-D3C8ORCIDhttp://orcid.org0000-0002-9593-1355Researcher IDhttps://www.researcherid.comQ-4930-2018Scopus Author IDhttps://www.scopus.com6506638953Paiva, AlexandreSimões, PedroPersonalFernandes, Virgínia CruzDSpacehttp://dspace.org/items/e30d74c3-1a3a-4e3e-ada0-5e79362cdd6eDSpacehttp://dspace.org/items/e30d74c3-1a3a-4e3e-ada0-5e79362cdd6eFernandesVirgíniaCiência IDhttps://www.ciencia-id.pt5A16-3713-E0CEORCIDhttp://orcid.org0000-0003-3979-7523Researcher IDhttps://www.researcherid.comG-4985-2010Scopus Author IDhttps://www.scopus.com37045954500Vieira, MónicaPersonalDelerue-Matos, CristinaDSpacehttp://dspace.org/items/09f6a7bd-2f15-42b0-adc5-04bd22210519DSpacehttp://dspace.org/items/09f6a7bd-2f15-42b0-adc5-04bd22210519Delerue-MatosCristinaCiência IDhttps://www.ciencia-id.pt9A1A-43FB-5C27ORCIDhttp://orcid.org0000-0002-3924-776XResearcher IDhttps://www.researcherid.comD-4990-2013Scopus Author IDhttps://www.scopus.com6603741848PersonalSoares, CristinaDSpacehttp://dspace.org/items/72b9814d-0e56-42e0-a1d7-93cb47fb9ae0DSpacehttp://dspace.org/items/72b9814d-0e56-42e0-a1d7-93cb47fb9ae0Dias SoaresCristina MariaCiência IDhttps://www.ciencia-id.pt5016-4F99-C69DORCIDhttp://orcid.org0000-0003-0924-9681PersonalGrosso, ClaraDSpacehttp://dspace.org/items/f8a4443b-2748-4523-8219-691d0523d467DSpacehttp://dspace.org/items/f8a4443b-2748-4523-8219-691d0523d467GrossoAna ClaraCiência IDhttps://www.ciencia-id.pt711B-1170-4C32ORCIDhttp://orcid.org0000-0002-2457-8267Researcher IDhttps://www.researcherid.comB-9813-2013Scopus Author IDhttps://www.scopus.com25627935200HostingInstitutionOrganizationalREPOSITÓRIO P.PORTOe-mailmailto:recipp@sc.ipp.ptrecipp@sc.ipp.ptDOIIsPartOf10.3390/foods110507462023-01-25T15:32:23Z20222022-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.22/21863http://purl.org/coar/access_right/c_abf2open accessIodineMaillard reactionNeuroprotectionNitrosative stressOxidative stressPesticidesPharmaceuticalsSeaweedsTotal phenolic content695531 bytesFundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processesinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PTUIDB/50006/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaAssociated Laboratory for Green Chemistry - Clean Technologies and Processesinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PTUIDP/50006/20206817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaDES-ZYME: Biocatalysis in Natural Deep Eutectic Solvents.info:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F01146%2F2015%2FCP1293%2FCT0003/PTIF/01146/2015/CP1293/CT0003Investigador FCTCrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaFruitec-Modern analytical technologies for assess Persistent and Emergent Organic Pollutants in red fruitsinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F109153%2F2015/PTSFRH/BPD/109153/2015POR_NORTECrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2022http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://recipp.ipp.pt/bitstreams/850121b9-3879-4a6e-971c-af72863d4076/downloadFoods115746 |
| spellingShingle | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts Gomes, Inês Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content |
| status | SINGLETON |
| subject.fl_str_mv | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content |
| title | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_full | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_fullStr | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_full_unstemmed | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_short | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| title_sort | Evaluation of the Biological Potential of Himanthalia elongata (L.) S.F.Gray and Eisenia bicyclis (Kjellman) Setchell Subcritical Water Extracts |
| topic | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content |
| topic_facet | Iodine Maillard reaction Neuroprotection Nitrosative stress Oxidative stress Pesticides Pharmaceuticals Seaweeds Total phenolic content |
| url | http://hdl.handle.net/10400.22/21863 |
| visible | 1 |