Publicação
IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies
| Resumo: | Anti-glomerular basement membrane (anti-GBM) disease is an aggressive small vessel vasculitis usually mediated by IgG autoantibodies. We describe the case of a 73-year-old male with rapidly progressive renal failure that was diagnosed with IgA mediated anti-GBM disease associated with circulating anti-neutrophil cytoplasm antibodies (ANCA), where the diagnosis was established on kidney biopsy by detecting linear deposition of IgA along the GBM on immunofluorescence microscopy. Despite an intensive immunosuppressive regimen with plasmapheresis, steroids and oral cyclophosphamide, the disease progressed to end-stage renal failure and the patient was started on hemodialysis. |
|---|---|
| Autores principais: | Alves, Patrícia |
| Outros Autores: | Góis, Mário; Pereira, Tiago; Carvalho, Dulce; Nolasco, Fernando |
| Assunto: | IgA mediated anti-GBM disease Atypical anti-GBM disease Anti-GBM disease ANCA antibody HCC NEF |
| Ano: | 2024 |
| País: | Portugal |
| Tipo de documento: | texto |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Centro Hospitalar de Lisboa Central, EPE (CHLC) |
| Idioma: | inglês |
| Origem: | Repositório do Centro Hospitalar de Lisboa Central, EPE |
| _version_ | 1877769757363535872 |
|---|---|
| author | Alves, Patrícia |
| author2 | Góis, Mário Pereira, Tiago Carvalho, Dulce Nolasco, Fernando |
| author2_role | author author author author |
| author_facet | Alves, Patrícia Góis, Mário Pereira, Tiago Carvalho, Dulce Nolasco, Fernando |
| author_role | author |
| contributor_name_str_mv | Repositório da Unidade Local de Saúde São José |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Alves, Patrícia\"},{\"Person.name\":\"Góis, Mário\"},{\"Person.name\":\"Pereira, Tiago\"},{\"Person.name\":\"Carvalho, Dulce\"},{\"Person.name\":\"Nolasco, Fernando\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório da Unidade Local de Saúde São José |
| datacite.creators.creator.creatorName.fl_str_mv | Alves, Patrícia Góis, Mário Pereira, Tiago Carvalho, Dulce Nolasco, Fernando |
| datacite.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2025-12-29T11:30:45Z |
| datacite.date.embargoed.fl_str_mv | 2025-12-29T11:30:45Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | IgA mediated anti-GBM disease Atypical anti-GBM disease Anti-GBM disease ANCA antibody HCC NEF |
| datacite.titles.title.fl_str_mv | IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies |
| dc.contributor.none.fl_str_mv | Repositório da Unidade Local de Saúde São José |
| dc.creator.none.fl_str_mv | Alves, Patrícia Góis, Mário Pereira, Tiago Carvalho, Dulce Nolasco, Fernando |
| dc.date.Accepted.fl_str_mv | 2024-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2025-12-29T11:30:45Z |
| dc.date.embargoed.fl_str_mv | 2025-12-29T11:30:45Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.17/5315 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Society of Diabetic Nephropathy Prevention |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | IgA mediated anti-GBM disease Atypical anti-GBM disease Anti-GBM disease ANCA antibody HCC NEF |
| dc.title.fl_str_mv | IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_18cf |
| description | Anti-glomerular basement membrane (anti-GBM) disease is an aggressive small vessel vasculitis usually mediated by IgG autoantibodies. We describe the case of a 73-year-old male with rapidly progressive renal failure that was diagnosed with IgA mediated anti-GBM disease associated with circulating anti-neutrophil cytoplasm antibodies (ANCA), where the diagnosis was established on kidney biopsy by detecting linear deposition of IgA along the GBM on immunofluorescence microscopy. Despite an intensive immunosuppressive regimen with plasmapheresis, steroids and oral cyclophosphamide, the disease progressed to end-stage renal failure and the patient was started on hemodialysis. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | text |
| fulltext.url.fl_str_mv | https://repositorio.chlc.pt/bitstreams/a6e99a0c-9131-43a9-9f7a-996d3c152125/download |
| id | rchlc_4ebefcd32f9dd8a6d69db7fc483d11be |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.17/5315 |
| inst_facet_str | urn:organizationAcronym:chlc{{{_:::_}}}Centro Hospitalar de Lisboa Central, EPE (CHLC) |
| instacron_str | chlc |
| institution | Centro Hospitalar de Lisboa Central, EPE (CHLC) |
| instname_str | Centro Hospitalar de Lisboa Central, EPE (CHLC) |
| language | eng |
| network_acronym_str | rchlc |
| network_name_str | Repositório do Centro Hospitalar de Lisboa Central, EPE |
| oai_identifier_str | oai:repositorio.chlc.pt:10400.17/5315 |
| organization_str_mv | urn:organizationAcronym:chlc |
| person_str_mv | Alves, Patrícia Góis, Mário Pereira, Tiago Carvalho, Dulce Nolasco, Fernando |
| publishDate | 2024 |
| publisher.none.fl_str_mv | Society of Diabetic Nephropathy Prevention |
| repo_facet_str | urn:repositoryAcronym:rchlc{{{_:::_}}}Repositório do Centro Hospitalar de Lisboa Central, EPE |
| reponame_str | Repositório do Centro Hospitalar de Lisboa Central, EPE |
| repository_id_str | urn:repositoryAcronym:rchlc |
| service_str_mv | urn:repositoryAcronym:rchlc |
| spelling | engSociety of Diabetic Nephropathy PreventionengAnti-glomerular basement membrane (anti-GBM) disease is an aggressive small vessel vasculitis usually mediated by IgG autoantibodies. We describe the case of a 73-year-old male with rapidly progressive renal failure that was diagnosed with IgA mediated anti-GBM disease associated with circulating anti-neutrophil cytoplasm antibodies (ANCA), where the diagnosis was established on kidney biopsy by detecting linear deposition of IgA along the GBM on immunofluorescence microscopy. Despite an intensive immunosuppressive regimen with plasmapheresis, steroids and oral cyclophosphamide, the disease progressed to end-stage renal failure and the patient was started on hemodialysis.application/pdfporIgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm AntibodiesAlves, PatríciaGóis, MárioPereira, TiagoCarvalho, DulceNolasco, FernandoHostingInstitutionOrganizationalRepositório da Unidade Local de Saúde São Josée-mailmailto:repositorio@ulssjose.min-saude.ptrepositorio@ulssjose.min-saude.ptDOIIsPartOf10.34172/jnp.2023.173712025-12-29T11:30:45Z20242024-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.17/5315http://purl.org/coar/access_right/c_abf2open accessIgA mediated anti-GBM diseaseAtypical anti-GBM diseaseAnti-GBM diseaseANCA antibodyHCC NEF908086 bytesother research producthttp://purl.org/coar/resource_type/c_18cftext2024http://creativecommons.org/licenses/by-nc/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://repositorio.chlc.pt/bitstreams/a6e99a0c-9131-43a9-9f7a-996d3c152125/download132e17371 |
| spellingShingle | IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies Alves, Patrícia IgA mediated anti-GBM disease Atypical anti-GBM disease Anti-GBM disease ANCA antibody HCC NEF |
| status | SINGLETON |
| subject.fl_str_mv | IgA mediated anti-GBM disease Atypical anti-GBM disease Anti-GBM disease ANCA antibody HCC NEF |
| title | IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies |
| title_full | IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies |
| title_fullStr | IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies |
| title_full_unstemmed | IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies |
| title_short | IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies |
| title_sort | IgA Mediated Anti-Glomerular Basement Membrane Disease with Associated Circulating Anti-Neutrophil Cytoplasm Antibodies |
| topic | IgA mediated anti-GBM disease Atypical anti-GBM disease Anti-GBM disease ANCA antibody HCC NEF |
| topic_facet | IgA mediated anti-GBM disease Atypical anti-GBM disease Anti-GBM disease ANCA antibody HCC NEF |
| url | http://hdl.handle.net/10400.17/5315 |
| visible | 1 |
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