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Effects of catecholamines on volemic replacement with saline solution and the impact on heart rate variability in rabbits subjected to hemorrhage. A study by spectral analysis

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Resumo:PURPOSE: To verify the effects of different catecholamines on volemic expansion and on the autonomic nervous system in rabbits that were subjected to hemorrhage.METHODS: Twenty four rabbits subjected to hemorrhage (with a 25% loss of blood volume) and were randomly divided into four experimental groups: 1) HEMO Group underwent replacement with their own blood in an equal volume; 2) SS Group underwent replacement with saline solution (SS) in a volume that corresponded to three times the removed blood volume; 3) ISP Group underwent replacement with SS and isoprenaline; 4) FNL Group underwent replacement with SS and phenylephrine. Spectral Analysis of the heart rate and heart rate variability were performed from the recorded data. Hematocrit was measured throughout the experiment.RESULTS:Replacement with SS and an α- or β-agonist did not produce differences in the intravascular retention compared to replacement with SS alone. An analysis of HRV showed that the FNL group maintained the LF/HF ratio better than ISP and SS.CONCLUSIONS: No difference in vascular retention when α- or β- agonists were added to SS during post-hemorrhagic recovery. The animals in the FNL group maintained the integrity of the autonomic response within normal physiological standards during hemorrhagic stress.
Autores principais:Moraes,José Mariano Soares de
Outros Autores:Vane,Matheus Fachini; Rodrigues,Denise de Fátima; Mostarda,Cristiano Teixeira; Moraes,Thiago Soares Mendes Moreira de; Vane,Lucas Fachini; Ganem,Eliana Marisa; Cavalcanti,Ismar Lima; Módolo,Norma Sueli Pinheiro; Vane,Luiz Antonio
Assunto:Catecholamines Adrenergic alpha-Agonists adrenergic beta-Agonists Blood Volume Hemorrhage Autonomic Nervous System Rabbits
Ano:2014
País:Brasil
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:IBICT
Idioma:inglês
Origem:Oasisbr

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