Publicação
Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function
| Resumo: | Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in the elderly. The aim of this study was to explore the effects of AD on cardiac function and autonomic nervous function, and the feasibility of electrocardiogram (ECG) in monitoring the development of AD. APP/PS1 double transgenic mice were used in the Morris water maze (MWM) experiment to evaluate the changes of cognitive ability of AD mice, then the non-invasive ECG acquisition system was used and the changes of ECG intervals and heart rate variability (HRV) were analyzed. AD mice already had cognitive dysfunction at the age of 5 months, reaching the level of mild dementia, and the degree of dementia increased with the course of disease. There were no significant changes in ECG intervals in the AD group at each month. The mean square of successive RR interval differences, percentage of intervals >6 ms different from preceding interval, and normalized high frequency power component in the AD group were decreased and low-to-high frequency power ratio and normalized low frequency power component were increased. Combined with the results of the MWM, it was shown that the regulation mechanism of sympathetic and parasympathetic nerves in mice was already imbalanced in early stage AD, which was manifested as the increase of excessive activity of sympathetic nerves and the inhibition of parasympathetic activities. Therefore, ECG-based analysis of HRV may become a means of daily monitoring of AD and provide an auxiliary basis for clinical diagnosis. |
|---|---|
| Autores principais: | Geng,Duyan |
| Outros Autores: | Wang,Yan; Gao,Zeyu; Wang,Jiaxing; Liu,Xuanyu; Pang,Geng |
| Assunto: | Alzheimer’s disease Cognitive ability Electrocardiogram Heart rate variability Autonomic nerve function |
| Ano: | 2022 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| _version_ | 1871510984218116096 |
|---|---|
| author | Geng,Duyan |
| author2 | Wang,Yan Gao,Zeyu Wang,Jiaxing Liu,Xuanyu Pang,Geng |
| author2_role | author author author author author |
| author_facet | Geng,Duyan Wang,Yan Gao,Zeyu Wang,Jiaxing Liu,Xuanyu Pang,Geng |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Geng,Duyan\"},{\"Person.name\":\"Wang,Yan\"},{\"Person.name\":\"Gao,Zeyu\"},{\"Person.name\":\"Wang,Jiaxing\"},{\"Person.name\":\"Liu,Xuanyu\"},{\"Person.name\":\"Pang,Geng\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Geng,Duyan Wang,Yan Gao,Zeyu Wang,Jiaxing Liu,Xuanyu Pang,Geng |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Alzheimer’s disease Cognitive ability Electrocardiogram Heart rate variability Autonomic nerve function |
| datacite.titles.title.fl_str_mv | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function |
| dc.creator.none.fl_str_mv | Geng,Duyan Wang,Yan Gao,Zeyu Wang,Jiaxing Liu,Xuanyu Pang,Geng |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100601 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Associação Brasileira de Divulgação Científica |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Brazilian Journal of Medical and Biological Research v.55 2022 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| dc.subject.none.fl_str_mv | Alzheimer’s disease Cognitive ability Electrocardiogram Heart rate variability Autonomic nerve function |
| dc.title.fl_str_mv | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in the elderly. The aim of this study was to explore the effects of AD on cardiac function and autonomic nervous function, and the feasibility of electrocardiogram (ECG) in monitoring the development of AD. APP/PS1 double transgenic mice were used in the Morris water maze (MWM) experiment to evaluate the changes of cognitive ability of AD mice, then the non-invasive ECG acquisition system was used and the changes of ECG intervals and heart rate variability (HRV) were analyzed. AD mice already had cognitive dysfunction at the age of 5 months, reaching the level of mild dementia, and the degree of dementia increased with the course of disease. There were no significant changes in ECG intervals in the AD group at each month. The mean square of successive RR interval differences, percentage of intervals >6 ms different from preceding interval, and normalized high frequency power component in the AD group were decreased and low-to-high frequency power ratio and normalized low frequency power component were increased. Combined with the results of the MWM, it was shown that the regulation mechanism of sympathetic and parasympathetic nerves in mice was already imbalanced in early stage AD, which was manifested as the increase of excessive activity of sympathetic nerves and the inhibition of parasympathetic activities. Therefore, ECG-based analysis of HRV may become a means of daily monitoring of AD and provide an auxiliary basis for clinical diagnosis. |
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| language | eng |
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| person_str_mv | Geng,Duyan Wang,Yan Gao,Zeyu Wang,Jiaxing Liu,Xuanyu Pang,Geng |
| publishDate | 2022 |
| publisher.none.fl_str_mv | Associação Brasileira de Divulgação Científica |
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| spelling | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic functionGeng,DuyanWang,YanGao,ZeyuWang,JiaxingLiu,XuanyuPang,GengAlzheimer’s diseaseCognitive abilityElectrocardiogramHeart rate variabilityAutonomic nerve functionopen accesshttp://purl.org/coar/access_right/c_abf2http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100601URLhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100601URLHasVersion2022-01-01Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases in the elderly. The aim of this study was to explore the effects of AD on cardiac function and autonomic nervous function, and the feasibility of electrocardiogram (ECG) in monitoring the development of AD. APP/PS1 double transgenic mice were used in the Morris water maze (MWM) experiment to evaluate the changes of cognitive ability of AD mice, then the non-invasive ECG acquisition system was used and the changes of ECG intervals and heart rate variability (HRV) were analyzed. AD mice already had cognitive dysfunction at the age of 5 months, reaching the level of mild dementia, and the degree of dementia increased with the course of disease. There were no significant changes in ECG intervals in the AD group at each month. The mean square of successive RR interval differences, percentage of intervals >6 ms different from preceding interval, and normalized high frequency power component in the AD group were decreased and low-to-high frequency power ratio and normalized low frequency power component were increased. Combined with the results of the MWM, it was shown that the regulation mechanism of sympathetic and parasympathetic nerves in mice was already imbalanced in early stage AD, which was manifested as the increase of excessive activity of sympathetic nerves and the inhibition of parasympathetic activities. Therefore, ECG-based analysis of HRV may become a means of daily monitoring of AD and provide an auxiliary basis for clinical diagnosis.engtext/htmlAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research v.55 2022reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDCjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function Geng,Duyan Alzheimer’s disease Cognitive ability Electrocardiogram Heart rate variability Autonomic nerve function |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | Alzheimer’s disease Cognitive ability Electrocardiogram Heart rate variability Autonomic nerve function |
| title | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function |
| title_full | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function |
| title_fullStr | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function |
| title_full_unstemmed | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function |
| title_short | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function |
| title_sort | Effects of Alzheimer’s disease of varying severity on cardiac and autonomic function |
| topic | Alzheimer’s disease Cognitive ability Electrocardiogram Heart rate variability Autonomic nerve function |
| topic_facet | Alzheimer’s disease Cognitive ability Electrocardiogram Heart rate variability Autonomic nerve function |
| url | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100601 |
| visible | 1 |
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