Publicação
Biological activities of Juglans regia flowers
| Resumo: | Antidepressant, anti-inflammatory, antihypoxic and antioxidant activities of methanol extract of Juglans regia L., Juglandaceae, flower were investigated. Antidepressant activity was examined by forced swimming test and tail suspension test in mice. Antihypoxic activity was investigated in haemic and circulatory models. The effects were pronounced in both models. It produced statistically significant anti-inflammatory activity in carrageenan induced edema at nearly all doses, compared to control groups. IC50 for DPPH radical-scavenging activity was 674±27.6 µg mL-1. Extract showed good Fe2+ chelating ability (IC50 43±1.5 µg mL-1). It exhibited low antioxidant activity in linoleic acid peroxidation test. Its pharmacological effects may be attributed, in part, to the presence of phenols and ISSN 0102-695X flavonoids in the extract. |
|---|---|
| Autores principais: | Nabavi,Seyed Fazel |
| Outros Autores: | Ebrahimzadeh,Mohammad Ali; Nabavi,Seyed Mohammad; Mahmoudi,Mitra; Rad,Shabnam Keyvani |
| Assunto: | antidepressant activity antioxidant activitywhen antihypoxic activity Juglans regia |
| Ano: | 2011 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| _version_ | 1871507347769131008 |
|---|---|
| author | Nabavi,Seyed Fazel |
| author2 | Ebrahimzadeh,Mohammad Ali Nabavi,Seyed Mohammad Mahmoudi,Mitra Rad,Shabnam Keyvani |
| author2_role | author author author author |
| author_facet | Nabavi,Seyed Fazel Ebrahimzadeh,Mohammad Ali Nabavi,Seyed Mohammad Mahmoudi,Mitra Rad,Shabnam Keyvani |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Nabavi,Seyed Fazel\"},{\"Person.name\":\"Ebrahimzadeh,Mohammad Ali\"},{\"Person.name\":\"Nabavi,Seyed Mohammad\"},{\"Person.name\":\"Mahmoudi,Mitra\"},{\"Person.name\":\"Rad,Shabnam Keyvani\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Nabavi,Seyed Fazel Ebrahimzadeh,Mohammad Ali Nabavi,Seyed Mohammad Mahmoudi,Mitra Rad,Shabnam Keyvani |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | antidepressant activity antioxidant activitywhen antihypoxic activity Juglans regia |
| datacite.titles.title.fl_str_mv | Biological activities of Juglans regia flowers |
| dc.creator.none.fl_str_mv | Nabavi,Seyed Fazel Ebrahimzadeh,Mohammad Ali Nabavi,Seyed Mohammad Mahmoudi,Mitra Rad,Shabnam Keyvani |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300018 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Brasileira de Farmacognosia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Revista Brasileira de Farmacognosia v.21 n.3 2011 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| dc.subject.none.fl_str_mv | antidepressant activity antioxidant activitywhen antihypoxic activity Juglans regia |
| dc.title.fl_str_mv | Biological activities of Juglans regia flowers |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Antidepressant, anti-inflammatory, antihypoxic and antioxidant activities of methanol extract of Juglans regia L., Juglandaceae, flower were investigated. Antidepressant activity was examined by forced swimming test and tail suspension test in mice. Antihypoxic activity was investigated in haemic and circulatory models. The effects were pronounced in both models. It produced statistically significant anti-inflammatory activity in carrageenan induced edema at nearly all doses, compared to control groups. IC50 for DPPH radical-scavenging activity was 674±27.6 µg mL-1. Extract showed good Fe2+ chelating ability (IC50 43±1.5 µg mL-1). It exhibited low antioxidant activity in linoleic acid peroxidation test. Its pharmacological effects may be attributed, in part, to the presence of phenols and ISSN 0102-695X flavonoids in the extract. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | oasisbr_cadd6cd509bee8c29aebb79d5d3edc6b |
| identifier.url.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300018 |
| inst_facet_str | urn:organizationAcronym:oasisbr{{{_:::_}}}IBICT |
| instacron_str | OASISBR |
| institution | IBICT |
| instname_str | IBICT |
| language | eng |
| network_acronym_str | oasisbr |
| network_name_str | Oasisbr |
| oai_identifier_str | oai:scielo:S0102-695X2011000300018 |
| organization_str_mv | urn:organizationAcronym:oasisbr |
| person_str_mv | Nabavi,Seyed Fazel Ebrahimzadeh,Mohammad Ali Nabavi,Seyed Mohammad Mahmoudi,Mitra Rad,Shabnam Keyvani |
| publishDate | 2011 |
| publisher.none.fl_str_mv | Sociedade Brasileira de Farmacognosia |
| repo_facet_str | urn:repositoryAcronym:oasisbr{{{_:::_}}}Oasisbr |
| reponame_str | Oasisbr |
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| spelling | Biological activities of Juglans regia flowersNabavi,Seyed FazelEbrahimzadeh,Mohammad AliNabavi,Seyed MohammadMahmoudi,MitraRad,Shabnam Keyvaniantidepressant activityantioxidant activitywhenantihypoxic activityJuglans regiaopen accesshttp://purl.org/coar/access_right/c_abf2http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300018URLhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300018URLHasVersion2011-06-01Antidepressant, anti-inflammatory, antihypoxic and antioxidant activities of methanol extract of Juglans regia L., Juglandaceae, flower were investigated. Antidepressant activity was examined by forced swimming test and tail suspension test in mice. Antihypoxic activity was investigated in haemic and circulatory models. The effects were pronounced in both models. It produced statistically significant anti-inflammatory activity in carrageenan induced edema at nearly all doses, compared to control groups. IC50 for DPPH radical-scavenging activity was 674±27.6 µg mL-1. Extract showed good Fe2+ chelating ability (IC50 43±1.5 µg mL-1). It exhibited low antioxidant activity in linoleic acid peroxidation test. Its pharmacological effects may be attributed, in part, to the presence of phenols and ISSN 0102-695X flavonoids in the extract.engtext/htmlSociedade Brasileira de FarmacognosiaRevista Brasileira de Farmacognosia v.21 n.3 2011reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIAjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Biological activities of Juglans regia flowers Nabavi,Seyed Fazel antidepressant activity antioxidant activitywhen antihypoxic activity Juglans regia |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | antidepressant activity antioxidant activitywhen antihypoxic activity Juglans regia |
| title | Biological activities of Juglans regia flowers |
| title_full | Biological activities of Juglans regia flowers |
| title_fullStr | Biological activities of Juglans regia flowers |
| title_full_unstemmed | Biological activities of Juglans regia flowers |
| title_short | Biological activities of Juglans regia flowers |
| title_sort | Biological activities of Juglans regia flowers |
| topic | antidepressant activity antioxidant activitywhen antihypoxic activity Juglans regia |
| topic_facet | antidepressant activity antioxidant activitywhen antihypoxic activity Juglans regia |
| url | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2011000300018 |
| visible | 1 |
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