Publication
Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles
| Summary: | Calcium phosphates and bioactive glasses have been used in many biomedical applications for more than 30 years due basically to their bioactive behavior. However, ceramics are too brittle for applications that require high levels of toughness and easy processability. In this work, a biphasic calcium phosphate (BCP) and a bioactive glass composition (BG) were combined with polymers to produce composites with tailorable properties and processability. The BCP particles were synthesized by a precipitation technique. The BG particles were produced by sol-gel processing. The BCP particles were treated with a silane agent to improve the compatibility between particles and the polymer matrix. Dense samples were produced by hot pressing (200 °C) a mixture of 30 wt.% of particles in poly (methyl methacrylate). The samples produced were characterized by X-ray diffraction, infrared spectroscopy and scanning electron microscopy. Mechanical properties were evaluated by a three point bending test. Samples were also submitted to in vitro bioactivity test and in vivo toxicity test. Results showed that the production of the composites was successfully achieved, yielding materials with particles well dispersed within the matrices. Evaluation of the in vivo inflammatory response showed low activity levels for all composites although composites with silane treated BCP particles led to milder inflammatory responses than composites with non-treated particles. |
|---|---|
| Main Authors: | Pereira,Marivalda de Magalhães |
| Other Authors: | Oréfice,Rodrigo Lambert; Mansur,Herman Sander; Lopes,Miriam Teresa Paz; Turchetti-Maia,Regina Maria De Marco; Vasconcelos,Anilton Cesar |
| Subject: | biomaterials composites poly(methyl methacrylate) bioactive glass calcium phosphate |
| Year: | 2003 |
| Country: | Brazil |
| Document type: | article |
| Access type: | open access |
| Associated institution: | IBICT |
| Language: | English |
| Origin: | Oasisbr |
| _version_ | 1871510268938289152 |
|---|---|
| author | Pereira,Marivalda de Magalhães |
| author2 | Oréfice,Rodrigo Lambert Mansur,Herman Sander Lopes,Miriam Teresa Paz Turchetti-Maia,Regina Maria De Marco Vasconcelos,Anilton Cesar |
| author2_role | author author author author author |
| author_facet | Pereira,Marivalda de Magalhães Oréfice,Rodrigo Lambert Mansur,Herman Sander Lopes,Miriam Teresa Paz Turchetti-Maia,Regina Maria De Marco Vasconcelos,Anilton Cesar |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Pereira,Marivalda de Magalhães\"},{\"Person.name\":\"Oréfice,Rodrigo Lambert\"},{\"Person.name\":\"Mansur,Herman Sander\"},{\"Person.name\":\"Lopes,Miriam Teresa Paz\"},{\"Person.name\":\"Turchetti-Maia,Regina Maria De Marco\"},{\"Person.name\":\"Vasconcelos,Anilton Cesar\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Pereira,Marivalda de Magalhães Oréfice,Rodrigo Lambert Mansur,Herman Sander Lopes,Miriam Teresa Paz Turchetti-Maia,Regina Maria De Marco Vasconcelos,Anilton Cesar |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | biomaterials composites poly(methyl methacrylate) bioactive glass calcium phosphate |
| datacite.titles.title.fl_str_mv | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles |
| dc.creator.none.fl_str_mv | Pereira,Marivalda de Magalhães Oréfice,Rodrigo Lambert Mansur,Herman Sander Lopes,Miriam Teresa Paz Turchetti-Maia,Regina Maria De Marco Vasconcelos,Anilton Cesar |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392003000300002 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | ABM, ABC, ABPol |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Materials Research v.6 n.3 2003 reponame:Materials research (São Carlos. Online) instname:Universidade Federal de São Carlos (UFSCAR) instacron:ABM ABC ABPOL |
| dc.subject.none.fl_str_mv | biomaterials composites poly(methyl methacrylate) bioactive glass calcium phosphate |
| dc.title.fl_str_mv | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Calcium phosphates and bioactive glasses have been used in many biomedical applications for more than 30 years due basically to their bioactive behavior. However, ceramics are too brittle for applications that require high levels of toughness and easy processability. In this work, a biphasic calcium phosphate (BCP) and a bioactive glass composition (BG) were combined with polymers to produce composites with tailorable properties and processability. The BCP particles were synthesized by a precipitation technique. The BG particles were produced by sol-gel processing. The BCP particles were treated with a silane agent to improve the compatibility between particles and the polymer matrix. Dense samples were produced by hot pressing (200 °C) a mixture of 30 wt.% of particles in poly (methyl methacrylate). The samples produced were characterized by X-ray diffraction, infrared spectroscopy and scanning electron microscopy. Mechanical properties were evaluated by a three point bending test. Samples were also submitted to in vitro bioactivity test and in vivo toxicity test. Results showed that the production of the composites was successfully achieved, yielding materials with particles well dispersed within the matrices. Evaluation of the in vivo inflammatory response showed low activity levels for all composites although composites with silane treated BCP particles led to milder inflammatory responses than composites with non-treated particles. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | oasisbr_b8cd162f1a976ffcb07d16ff8685e421 |
| identifier.url.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392003000300002 |
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| institution | IBICT |
| instname_str | IBICT |
| language | eng |
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| oai_identifier_str | oai:scielo:S1516-14392003000300002 |
| organization_str_mv | urn:organizationAcronym:oasisbr |
| person_str_mv | Pereira,Marivalda de Magalhães Oréfice,Rodrigo Lambert Mansur,Herman Sander Lopes,Miriam Teresa Paz Turchetti-Maia,Regina Maria De Marco Vasconcelos,Anilton Cesar |
| publishDate | 2003 |
| publisher.none.fl_str_mv | ABM, ABC, ABPol |
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| spelling | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particlesPereira,Marivalda de MagalhãesOréfice,Rodrigo LambertMansur,Herman SanderLopes,Miriam Teresa PazTurchetti-Maia,Regina Maria De MarcoVasconcelos,Anilton Cesarbiomaterialscompositespoly(methyl methacrylate)bioactive glasscalcium phosphateopen accesshttp://purl.org/coar/access_right/c_abf2http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392003000300002URLhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392003000300002URLHasVersion2003-06-01Calcium phosphates and bioactive glasses have been used in many biomedical applications for more than 30 years due basically to their bioactive behavior. However, ceramics are too brittle for applications that require high levels of toughness and easy processability. In this work, a biphasic calcium phosphate (BCP) and a bioactive glass composition (BG) were combined with polymers to produce composites with tailorable properties and processability. The BCP particles were synthesized by a precipitation technique. The BG particles were produced by sol-gel processing. The BCP particles were treated with a silane agent to improve the compatibility between particles and the polymer matrix. Dense samples were produced by hot pressing (200 °C) a mixture of 30 wt.% of particles in poly (methyl methacrylate). The samples produced were characterized by X-ray diffraction, infrared spectroscopy and scanning electron microscopy. Mechanical properties were evaluated by a three point bending test. Samples were also submitted to in vitro bioactivity test and in vivo toxicity test. Results showed that the production of the composites was successfully achieved, yielding materials with particles well dispersed within the matrices. Evaluation of the in vivo inflammatory response showed low activity levels for all composites although composites with silane treated BCP particles led to milder inflammatory responses than composites with non-treated particles.engtext/htmlABM, ABC, ABPolMaterials Research v.6 n.3 2003reponame:Materials research (São Carlos. Online)instname:Universidade Federal de São Carlos (UFSCAR)instacron:ABM ABC ABPOLjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles Pereira,Marivalda de Magalhães biomaterials composites poly(methyl methacrylate) bioactive glass calcium phosphate |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | biomaterials composites poly(methyl methacrylate) bioactive glass calcium phosphate |
| title | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles |
| title_full | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles |
| title_fullStr | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles |
| title_full_unstemmed | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles |
| title_short | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles |
| title_sort | Preparation and biocompatibility of poly (methyl methacrylate) reinforced with bioactive particles |
| topic | biomaterials composites poly(methyl methacrylate) bioactive glass calcium phosphate |
| topic_facet | biomaterials composites poly(methyl methacrylate) bioactive glass calcium phosphate |
| url | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392003000300002 |
| visible | 1 |
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