Publicação
Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (Zingiberaceae)
| Resumo: | Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (AECS) were studied in rats and mice. In non anaesthetized normotensive rats (n = 6), AECS (0.5, 1.0, 5.0 and 10.0 mg/kg; i.v., randomly) induced hypotension associated with tachycardia. In intact or endothelium-denuded rings of rat superior mesenteric artery, AECS (0.1 - 100.0 μ g/ mL, n = 4) provoked relaxation of the tonus induced by 10 μ M phenylephrine. The extract showed low acute toxicity in mic |
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| Autores principais: | Menezes, Igor Alexandre Côrtes |
| Outros Autores: | Carvalho, Adriana Andrade; Antoniolli, Angelo Roberto; Santos, Márcio Roberto Viana |
| Assunto: | Toxicidade Aguda Zingiberaceae |
| Ano: | 2013 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| Resumo: | Cardiovascular effects and acute toxicity of the aqueous extract of Costus spicatus leaves (AECS) were studied in rats and mice. In non anaesthetized normotensive rats (n = 6), AECS (0.5, 1.0, 5.0 and 10.0 mg/kg; i.v., randomly) induced hypotension associated with tachycardia. In intact or endothelium-denuded rings of rat superior mesenteric artery, AECS (0.1 - 100.0 μ g/ mL, n = 4) provoked relaxation of the tonus induced by 10 μ M phenylephrine. The extract showed low acute toxicity in mic |
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