Publicação
Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro
| Resumo: | Introduction: To evaluate the efficacy, safety, and tolerability of sertraline for the treatment of Brazilian patients with mild to moderate major depression. Patients and methods: Patients were 18 years old or older treated on an out-patient basis. Previous medications were stopped for a 2-week washout period. Afterwards, patients received sertraline, initial dose of 50 mg/day up to the 4 th week. The dose could then be increased up to 200 mg/day according to the efficacy and tolerability. Therapeutic efficacy was evaluated with the Montgomery-Asberg Depression Rating Scale (MADRS), Hamilton scale for depression (HAM-D), and Clinical Global Impression (CGI). Results: 51 patients (42 women) were evaluated regarding efficacy and safety. Treatment with sertraline significantly decreased scores of MADRS, HAM-D e ICGfrom 15.7 ± 6.1; 12.2 ± 3.9 e 3.5 ± 0.6 to 6.2 ± 6.5; 5.4 ± 4.7 e 2.3 ± 1.0 (P < 0.0001), respectively. Sertraline was well tolerated. Gastro-intestinal upset (N=14; 24.6%), headache (N=7; 12.3%), sleep alterations (H-7; 12.3%), dizziness (N-4; 7.0%), and anorexia (N=4; 7.0%) were the most common adverse events. Six patients discontinued the treatment due to adverse events. Conclusion: Sertraline is efficient and presents a favorable safety and tolerability profile for the treatment of Brazilian patients with mild to moderate major depression. © Copyright Moreira Jr. Editora. |
|---|---|
| Autores principais: | Neto, Abrahão Afiune |
| Outros Autores: | Barea, Liselotte Menke; Calamita, Zamir; Cavalcanti, Fernando; Pippa, Maria Guadalupe Barbosa |
| Assunto: | Depressive disorder Drug therapy Serotonin uptake inhibitors Sertraline sertraline adult anorexia Clinical Global Impression scale controlled study depression disease severity dizziness drug efficacy drug safety drug tolerability drug withdrawal female gastrointestinal symptom headache human major clinical study male sleep disorder |
| Ano: | 2014 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | português |
| Origem: | Oasisbr |
| _version_ | 1871537679694299136 |
|---|---|
| author | Neto, Abrahão Afiune |
| author2 | Barea, Liselotte Menke Calamita, Zamir Cavalcanti, Fernando Pippa, Maria Guadalupe Barbosa |
| author2_role | author author author author |
| author_facet | Neto, Abrahão Afiune Barea, Liselotte Menke Calamita, Zamir Cavalcanti, Fernando Pippa, Maria Guadalupe Barbosa |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Neto, Abrahão Afiune\"},{\"Person.name\":\"Barea, Liselotte Menke\"},{\"Person.name\":\"Calamita, Zamir\"},{\"Person.name\":\"Cavalcanti, Fernando\"},{\"Person.name\":\"Pippa, Maria Guadalupe Barbosa\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Neto, Abrahão Afiune Barea, Liselotte Menke Calamita, Zamir Cavalcanti, Fernando Pippa, Maria Guadalupe Barbosa |
| datacite.date.Accepted.fl_str_mv | 2007-03-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2014-05-27T11:22:26Z |
| datacite.date.embargoed.fl_str_mv | 2014-05-27T11:22:26Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Depressive disorder Drug therapy Serotonin uptake inhibitors Sertraline sertraline adult anorexia Clinical Global Impression scale controlled study depression disease severity dizziness drug efficacy drug safety drug tolerability drug withdrawal female gastrointestinal symptom headache human major clinical study male sleep disorder |
| datacite.titles.title.fl_str_mv | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro |
| dc.creator.none.fl_str_mv | Neto, Abrahão Afiune Barea, Liselotte Menke Calamita, Zamir Cavalcanti, Fernando Pippa, Maria Guadalupe Barbosa |
| dc.date.Accepted.fl_str_mv | 2007-03-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2014-05-27T11:22:26Z |
| dc.date.embargoed.fl_str_mv | 2014-05-27T11:22:26Z |
| dc.format.none.fl_str_mv | 132-137 |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/11449/69570 |
| dc.language.none.fl_str_mv | por |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
| dc.subject.none.fl_str_mv | Depressive disorder Drug therapy Serotonin uptake inhibitors Sertraline sertraline adult anorexia Clinical Global Impression scale controlled study depression disease severity dizziness drug efficacy drug safety drug tolerability drug withdrawal female gastrointestinal symptom headache human major clinical study male sleep disorder |
| dc.title.fl_str_mv | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Introduction: To evaluate the efficacy, safety, and tolerability of sertraline for the treatment of Brazilian patients with mild to moderate major depression. Patients and methods: Patients were 18 years old or older treated on an out-patient basis. Previous medications were stopped for a 2-week washout period. Afterwards, patients received sertraline, initial dose of 50 mg/day up to the 4 th week. The dose could then be increased up to 200 mg/day according to the efficacy and tolerability. Therapeutic efficacy was evaluated with the Montgomery-Asberg Depression Rating Scale (MADRS), Hamilton scale for depression (HAM-D), and Clinical Global Impression (CGI). Results: 51 patients (42 women) were evaluated regarding efficacy and safety. Treatment with sertraline significantly decreased scores of MADRS, HAM-D e ICGfrom 15.7 ± 6.1; 12.2 ± 3.9 e 3.5 ± 0.6 to 6.2 ± 6.5; 5.4 ± 4.7 e 2.3 ± 1.0 (P < 0.0001), respectively. Sertraline was well tolerated. Gastro-intestinal upset (N=14; 24.6%), headache (N=7; 12.3%), sleep alterations (H-7; 12.3%), dizziness (N-4; 7.0%), and anorexia (N=4; 7.0%) were the most common adverse events. Six patients discontinued the treatment due to adverse events. Conclusion: Sertraline is efficient and presents a favorable safety and tolerability profile for the treatment of Brazilian patients with mild to moderate major depression. © Copyright Moreira Jr. Editora. |
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| eu_rights_str_mv | openAccess |
| format | article |
| id | oasisbr_a2fd7ebc5612d461fd5dad5192f9b5cc |
| identifier.url.fl_str_mv | http://hdl.handle.net/11449/69570 |
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| institution | IBICT |
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| language | por |
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| oai_identifier_str | oai:repositorio.unesp.br:11449/69570 |
| organization_str_mv | urn:organizationAcronym:oasisbr |
| person_str_mv | Neto, Abrahão Afiune Barea, Liselotte Menke Calamita, Zamir Cavalcanti, Fernando Pippa, Maria Guadalupe Barbosa |
| publishDate | 2014 |
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| spelling | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiroNeto, Abrahão AfiuneBarea, Liselotte MenkeCalamita, ZamirCavalcanti, FernandoPippa, Maria Guadalupe BarbosaDepressive disorderDrug therapySerotonin uptake inhibitorsSertralinesertralineadultanorexiaClinical Global Impression scalecontrolled studydepressiondisease severitydizzinessdrug efficacydrug safetydrug tolerabilitydrug withdrawalfemalegastrointestinal symptomheadachehumanmajor clinical studymalesleep disorderopen accesshttp://purl.org/coar/access_right/c_abf2http://hdl.handle.net/11449/69570Handlehttp://www.moreirajr.com.br/revistas.asp?fase=r003&id_materia=3527URLHasVersionRevista Brasileira de Medicina, v. 64, n. 3, p. 132-137, 2007.N/AHasVersion0034-7264N/AHasVersion2-s2.0-34248547545N/AHasVersionhttp://hdl.handle.net/11449/69570Handle2014-05-27T11:22:26Z2014-05-272007-03-01T00:00:00ZIntroduction: To evaluate the efficacy, safety, and tolerability of sertraline for the treatment of Brazilian patients with mild to moderate major depression. Patients and methods: Patients were 18 years old or older treated on an out-patient basis. Previous medications were stopped for a 2-week washout period. Afterwards, patients received sertraline, initial dose of 50 mg/day up to the 4 th week. The dose could then be increased up to 200 mg/day according to the efficacy and tolerability. Therapeutic efficacy was evaluated with the Montgomery-Asberg Depression Rating Scale (MADRS), Hamilton scale for depression (HAM-D), and Clinical Global Impression (CGI). Results: 51 patients (42 women) were evaluated regarding efficacy and safety. Treatment with sertraline significantly decreased scores of MADRS, HAM-D e ICGfrom 15.7 ± 6.1; 12.2 ± 3.9 e 3.5 ± 0.6 to 6.2 ± 6.5; 5.4 ± 4.7 e 2.3 ± 1.0 (P < 0.0001), respectively. Sertraline was well tolerated. Gastro-intestinal upset (N=14; 24.6%), headache (N=7; 12.3%), sleep alterations (H-7; 12.3%), dizziness (N-4; 7.0%), and anorexia (N=4; 7.0%) were the most common adverse events. Six patients discontinued the treatment due to adverse events. Conclusion: Sertraline is efficient and presents a favorable safety and tolerability profile for the treatment of Brazilian patients with mild to moderate major depression. © Copyright Moreira Jr. Editora.por132-137reponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro Neto, Abrahão Afiune Depressive disorder Drug therapy Serotonin uptake inhibitors Sertraline sertraline adult anorexia Clinical Global Impression scale controlled study depression disease severity dizziness drug efficacy drug safety drug tolerability drug withdrawal female gastrointestinal symptom headache human major clinical study male sleep disorder |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | Depressive disorder Drug therapy Serotonin uptake inhibitors Sertraline sertraline adult anorexia Clinical Global Impression scale controlled study depression disease severity dizziness drug efficacy drug safety drug tolerability drug withdrawal female gastrointestinal symptom headache human major clinical study male sleep disorder |
| title | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro |
| title_full | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro |
| title_fullStr | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro |
| title_full_unstemmed | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro |
| title_short | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro |
| title_sort | Sertralina no tratamento de pacientes com depressão maior leve e moderada: Estudo multicêntrico brasileiro |
| topic | Depressive disorder Drug therapy Serotonin uptake inhibitors Sertraline sertraline adult anorexia Clinical Global Impression scale controlled study depression disease severity dizziness drug efficacy drug safety drug tolerability drug withdrawal female gastrointestinal symptom headache human major clinical study male sleep disorder |
| topic_facet | Depressive disorder Drug therapy Serotonin uptake inhibitors Sertraline sertraline adult anorexia Clinical Global Impression scale controlled study depression disease severity dizziness drug efficacy drug safety drug tolerability drug withdrawal female gastrointestinal symptom headache human major clinical study male sleep disorder |
| url | http://hdl.handle.net/11449/69570 |
| visible | 1 |
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