Publicação
The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy
| Resumo: | Amazon Foundation |
|---|---|
| Autores principais: | Falcão, Luiz Fábio Magno |
| Outros Autores: | Pontes, Lucieny da Silva; Silva, Bruno Giovanni Afonso da; Franco, Karen Margarete Vieira da Silva; Costa, Luiz Adriano Araujo da; Rocha, Rodrigo Santiago Barbosa; Quaresma, Juarez Antônio Simões |
| Assunto: | Síndrome Respiratória Aguda Grave / imunologia Vírus da SARS / isolamento & purificação Coronavirus / patogenicidade Infecções por Coronavirus Sistema Nervoso Lesão Pulmonar / patologia Manuseio das Vias Aéreas |
| Ano: | 2020 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso embargado |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| _version_ | 1871610434464776192 |
|---|---|
| author | Falcão, Luiz Fábio Magno |
| author2 | Pontes, Lucieny da Silva Silva, Bruno Giovanni Afonso da Franco, Karen Margarete Vieira da Silva Costa, Luiz Adriano Araujo da Rocha, Rodrigo Santiago Barbosa Quaresma, Juarez Antônio Simões |
| author2_role | author author author author author author |
| author_facet | Falcão, Luiz Fábio Magno Pontes, Lucieny da Silva Silva, Bruno Giovanni Afonso da Franco, Karen Margarete Vieira da Silva Costa, Luiz Adriano Araujo da Rocha, Rodrigo Santiago Barbosa Quaresma, Juarez Antônio Simões |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Falcão, Luiz Fábio Magno\"},{\"Person.name\":\"Pontes, Lucieny da Silva\"},{\"Person.name\":\"Silva, Bruno Giovanni Afonso da\"},{\"Person.name\":\"Franco, Karen Margarete Vieira da Silva\"},{\"Person.name\":\"Costa, Luiz Adriano Araujo da\"},{\"Person.name\":\"Rocha, Rodrigo Santiago Barbosa\"},{\"Person.name\":\"Quaresma, Juarez Antônio Simões\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Falcão, Luiz Fábio Magno Pontes, Lucieny da Silva Silva, Bruno Giovanni Afonso da Franco, Karen Margarete Vieira da Silva Costa, Luiz Adriano Araujo da Rocha, Rodrigo Santiago Barbosa Quaresma, Juarez Antônio Simões |
| datacite.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2020-10-13T13:22:21Z |
| datacite.date.embargoed.fl_str_mv | 2020-10-13T13:22:21Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_f1cf |
| datacite.subjects.subject.fl_str_mv | Síndrome Respiratória Aguda Grave / imunologia Vírus da SARS / isolamento & purificação Coronavirus / patogenicidade Infecções por Coronavirus Sistema Nervoso Lesão Pulmonar / patologia Manuseio das Vias Aéreas |
| datacite.titles.title.fl_str_mv | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy |
| dc.creator.none.fl_str_mv | Falcão, Luiz Fábio Magno Pontes, Lucieny da Silva Silva, Bruno Giovanni Afonso da Franco, Karen Margarete Vieira da Silva Costa, Luiz Adriano Araujo da Rocha, Rodrigo Santiago Barbosa Quaresma, Juarez Antônio Simões |
| dc.date.Accepted.fl_str_mv | 2020-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2020-10-13T13:22:21Z |
| dc.date.embargoed.fl_str_mv | 2020-10-13T13:22:21Z |
| dc.description.none.fl_str_mv | State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil. State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil. State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil. Federal University of Pará. Center for Tropical Medicine. Belém, PA, Brazil. State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil. State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil. State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil. Covid-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may present with polymorphic symptomatology and subclinical, neurological, gastrointestinal, dermatological, renal and severe acute respiratory manifestations. The diffuse alveolar damage caused by the disease presents with fibrin deposition, oedema, lymphocytic inflammatory infiltrate, destruction of epithelial cells, hyaline membrane formation and occasional angiogenesis formation of microthrombi. A common radiological finding is bilateral ground glass opacity, present even in mild cases. Severe cases occur mainly among the elderly and individuals with underlying comorbidities. Here, we provide an overview of the pathophysiology of the disease associated with SARS-CoV-2 infection, interaction of the virus with the immune system, and subsequent dysfunctional immune response, essential for progression of Covid-19. We also discuss the role of the nervous system as a possible aggravating agent of the respiratory condition and propose a protocol for airway management based on the pathophysiological and immunological characteristics of the disease. Finally, we highlight the implications of such approaches for future therapeutic intervention. |
| dc.identifier.none.fl_str_mv | https://doi.org/10.1002/rmv.2167 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_f1cf |
| dc.source.none.fl_str_mv | reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
| dc.subject.none.fl_str_mv | Síndrome Respiratória Aguda Grave / imunologia Vírus da SARS / isolamento & purificação Coronavirus / patogenicidade Infecções por Coronavirus Sistema Nervoso Lesão Pulmonar / patologia Manuseio das Vias Aéreas |
| dc.title.fl_str_mv | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Amazon Foundation |
| dirty | 0 |
| eu_rights_str_mv | embargoedAccess |
| format | article |
| id | oasisbr_9ffa6cc3d4dcd3c72bf13a4d8d9f2ec2 |
| identifier.doi.fl_str_mv | https://doi.org/10.1002/rmv.2167 |
| inst_facet_str | urn:organizationAcronym:oasisbr{{{_:::_}}}IBICT |
| instacron_str | OASISBR |
| institution | IBICT |
| instname_str | IBICT |
| language | eng |
| network_acronym_str | oasisbr |
| network_name_str | Oasisbr |
| oai_identifier_str | oai:patua.iec.gov.br:iec/4179 |
| organization_str_mv | urn:organizationAcronym:oasisbr |
| person_str_mv | Falcão, Luiz Fábio Magno Pontes, Lucieny da Silva Silva, Bruno Giovanni Afonso da Franco, Karen Margarete Vieira da Silva Costa, Luiz Adriano Araujo da Rocha, Rodrigo Santiago Barbosa Quaresma, Juarez Antônio Simões |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Wiley |
| repo_facet_str | urn:repositoryAcronym:oasisbr{{{_:::_}}}Oasisbr |
| reponame_str | Oasisbr |
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| spelling | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapyFalcão, Luiz Fábio MagnoPontes, Lucieny da SilvaSilva, Bruno Giovanni Afonso daFranco, Karen Margarete Vieira da SilvaCosta, Luiz Adriano Araujo daRocha, Rodrigo Santiago BarbosaQuaresma, Juarez Antônio SimõesSíndrome Respiratória Aguda Grave / imunologiaVírus da SARS / isolamento & purificaçãoCoronavirus / patogenicidadeInfecções por CoronavirusSistema NervosoLesão Pulmonar / patologiaManuseio das Vias Aéreasembargoed accesshttp://purl.org/coar/access_right/c_f1cfhttps://doi.org/10.1002/rmv.2167DOIFALÇÃO, Luiz Fábio Magno et al. The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy. Reviews in Medical Virology, v. 31, n. 2, e2167, Mar. 2021.N/AHasVersionhttps://patua.iec.gov.br/handle/iec/4179URLHasVersion1052-9276N/AHasVersionhttps://doi.org/10.1002/rmv.2167DOI2020-10-13T13:22:21Z2020-10-132020-01-01T00:00:00ZAmazon FoundationState University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.Federal University of Pará. Center for Tropical Medicine. Belém, PA, Brazil.State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil.State University of Pará. Center for Biological and Health Sciences. Belém, PA, Brazil / Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Covid-19, a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, may present with polymorphic symptomatology and subclinical, neurological, gastrointestinal, dermatological, renal and severe acute respiratory manifestations. The diffuse alveolar damage caused by the disease presents with fibrin deposition, oedema, lymphocytic inflammatory infiltrate, destruction of epithelial cells, hyaline membrane formation and occasional angiogenesis formation of microthrombi. A common radiological finding is bilateral ground glass opacity, present even in mild cases. Severe cases occur mainly among the elderly and individuals with underlying comorbidities. Here, we provide an overview of the pathophysiology of the disease associated with SARS-CoV-2 infection, interaction of the virus with the immune system, and subsequent dysfunctional immune response, essential for progression of Covid-19. We also discuss the role of the nervous system as a possible aggravating agent of the respiratory condition and propose a protocol for airway management based on the pathophysiological and immunological characteristics of the disease. Finally, we highlight the implications of such approaches for future therapeutic intervention.engWileyreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85journal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy Falcão, Luiz Fábio Magno Síndrome Respiratória Aguda Grave / imunologia Vírus da SARS / isolamento & purificação Coronavirus / patogenicidade Infecções por Coronavirus Sistema Nervoso Lesão Pulmonar / patologia Manuseio das Vias Aéreas |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | Síndrome Respiratória Aguda Grave / imunologia Vírus da SARS / isolamento & purificação Coronavirus / patogenicidade Infecções por Coronavirus Sistema Nervoso Lesão Pulmonar / patologia Manuseio das Vias Aéreas |
| title | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy |
| title_full | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy |
| title_fullStr | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy |
| title_full_unstemmed | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy |
| title_short | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy |
| title_sort | The complexity of respiratory disease associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection: from immunopathogenesis to respiratory therapy |
| topic | Síndrome Respiratória Aguda Grave / imunologia Vírus da SARS / isolamento & purificação Coronavirus / patogenicidade Infecções por Coronavirus Sistema Nervoso Lesão Pulmonar / patologia Manuseio das Vias Aéreas |
| topic_facet | Síndrome Respiratória Aguda Grave / imunologia Vírus da SARS / isolamento & purificação Coronavirus / patogenicidade Infecções por Coronavirus Sistema Nervoso Lesão Pulmonar / patologia Manuseio das Vias Aéreas |
| url | https://doi.org/10.1002/rmv.2167 |
| visible | 1 |
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