Publication
Development and use of mucosal vaccines: Potential and limitations
| Summary: | Mucosal surfaces represent a major gateway to microorganisms which may be harmful to health. The humoral immune response has an important action in the defense of these surfaces, as it is able to prevent the entry of pathogens in the body. Vaccines with local application have been evaluated in order to stimulate an efficient immune response in the mucous membranes, since conventional vaccines, for parenteral application, tend to stimulate a mostly systemic response. Vaccines that use the mucosa as an inoculation route are able to generate an immune response directly in the application mucosa and corresponding mucosa, since the mucosal system is integrated, which represents an important advantage in choosing the inoculation route. This paper aims to illustrate some concepts related to mucosal immunity in general, as well as to gather information about what has been studied in relation to mucosal routes of administration of vaccines, immunomodulators and antigen delivery systems. |
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| Main Authors: | Peter, Cristina Mendes |
| Other Authors: | Barcelos, Lariane da Silva; Frühauf, Matheus Iuri; Botton, Nadálin Yandra; Hübner, Silvia de Oliveira; Lima, Marcelo de; Barichello, José Mario; Fischer, Geferson |
| Subject: | Sistemas de entrega sistemas de entrega; inmunomoduladores; rutas de administracion; vacunas. Inmunomoduladores Rutas de administracion Vacunas. delivery systems; immunomodulators; routes of administration; vaccines Delivery systems Immunomodulators Routes of administration Vaccines. sistemas de entrega; imunomoduladores; vias de administração; vacinas. Sistemas de entrega Imunomoduladores Vias de administração Vacinas. |
| Year: | 2021 |
| Country: | Brazil |
| Document type: | article |
| Access type: | unknown |
| Associated institution: | IBICT |
| Language: | Portuguese |
| Origin: | Oasisbr |
| Summary: | Mucosal surfaces represent a major gateway to microorganisms which may be harmful to health. The humoral immune response has an important action in the defense of these surfaces, as it is able to prevent the entry of pathogens in the body. Vaccines with local application have been evaluated in order to stimulate an efficient immune response in the mucous membranes, since conventional vaccines, for parenteral application, tend to stimulate a mostly systemic response. Vaccines that use the mucosa as an inoculation route are able to generate an immune response directly in the application mucosa and corresponding mucosa, since the mucosal system is integrated, which represents an important advantage in choosing the inoculation route. This paper aims to illustrate some concepts related to mucosal immunity in general, as well as to gather information about what has been studied in relation to mucosal routes of administration of vaccines, immunomodulators and antigen delivery systems. |
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