Publicação
Antimoniais empregados no tratamento da leishmaniose: estado da arte
| Resumo: | Antimony preparations are the drugs of choice for the treatment of leishmaniasis over 90 years, a disease that currently affects 12 million people worldwide. Its introduction was based on 19th century concepts of therapeutic effects of metal salts as arsenicals and other metals, most of them abandoned due to toxic effects or better drugs. In the last three decades, there was a great improvement in the knowledge of cell biology and immunology of those infections, but chemotherapy has not been improved in the same strength. The structure and mechanism of action of the two pentavalent antimonial drugs of choice, meglumine antimoniate and sodium stibogluconate, are not well known and the contamination of those pharmaceutical by toxic contaminants have been verified. |
|---|---|
| Autores principais: | Rath,Susanne |
| Outros Autores: | Trivelin,Luciano Augusto; Imbrunito,Talitha Rebecca; Tomazela,Daniela Maria; Jesús,Marcelo Nunes de; Marzal,Percy Calvo; Andrade Junior,Heitor Franco de; Tempone,André Gustavo |
| Assunto: | antimony leishmaniasis therapy |
| Ano: | 2003 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | português |
| Origem: | Oasisbr |
| _version_ | 1871506467564027904 |
|---|---|
| author | Rath,Susanne |
| author2 | Trivelin,Luciano Augusto Imbrunito,Talitha Rebecca Tomazela,Daniela Maria Jesús,Marcelo Nunes de Marzal,Percy Calvo Andrade Junior,Heitor Franco de Tempone,André Gustavo |
| author2_role | author author author author author author author |
| author_facet | Rath,Susanne Trivelin,Luciano Augusto Imbrunito,Talitha Rebecca Tomazela,Daniela Maria Jesús,Marcelo Nunes de Marzal,Percy Calvo Andrade Junior,Heitor Franco de Tempone,André Gustavo |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Rath,Susanne\"},{\"Person.name\":\"Trivelin,Luciano Augusto\"},{\"Person.name\":\"Imbrunito,Talitha Rebecca\"},{\"Person.name\":\"Tomazela,Daniela Maria\"},{\"Person.name\":\"Jesús,Marcelo Nunes de\"},{\"Person.name\":\"Marzal,Percy Calvo\"},{\"Person.name\":\"Andrade Junior,Heitor Franco de\"},{\"Person.name\":\"Tempone,André Gustavo\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Rath,Susanne Trivelin,Luciano Augusto Imbrunito,Talitha Rebecca Tomazela,Daniela Maria Jesús,Marcelo Nunes de Marzal,Percy Calvo Andrade Junior,Heitor Franco de Tempone,André Gustavo |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | antimony leishmaniasis therapy |
| datacite.titles.title.fl_str_mv | Antimoniais empregados no tratamento da leishmaniose: estado da arte |
| dc.creator.none.fl_str_mv | Rath,Susanne Trivelin,Luciano Augusto Imbrunito,Talitha Rebecca Tomazela,Daniela Maria Jesús,Marcelo Nunes de Marzal,Percy Calvo Andrade Junior,Heitor Franco de Tempone,André Gustavo |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000400018 |
| dc.language.none.fl_str_mv | por |
| dc.publisher.none.fl_str_mv | Sociedade Brasileira de Química |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Química Nova v.26 n.4 2003 reponame:Química Nova (Online) instname:Sociedade Brasileira de Química (SBQ) instacron:SBQ |
| dc.subject.none.fl_str_mv | antimony leishmaniasis therapy |
| dc.title.fl_str_mv | Antimoniais empregados no tratamento da leishmaniose: estado da arte |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Antimony preparations are the drugs of choice for the treatment of leishmaniasis over 90 years, a disease that currently affects 12 million people worldwide. Its introduction was based on 19th century concepts of therapeutic effects of metal salts as arsenicals and other metals, most of them abandoned due to toxic effects or better drugs. In the last three decades, there was a great improvement in the knowledge of cell biology and immunology of those infections, but chemotherapy has not been improved in the same strength. The structure and mechanism of action of the two pentavalent antimonial drugs of choice, meglumine antimoniate and sodium stibogluconate, are not well known and the contamination of those pharmaceutical by toxic contaminants have been verified. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| id | oasisbr_892a85b4d543ec81598fb904c1265a08 |
| identifier.url.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000400018 |
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| instacron_str | OASISBR |
| institution | IBICT |
| instname_str | IBICT |
| language | por |
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| oai_identifier_str | oai:scielo:S0100-40422003000400018 |
| organization_str_mv | urn:organizationAcronym:oasisbr |
| person_str_mv | Rath,Susanne Trivelin,Luciano Augusto Imbrunito,Talitha Rebecca Tomazela,Daniela Maria Jesús,Marcelo Nunes de Marzal,Percy Calvo Andrade Junior,Heitor Franco de Tempone,André Gustavo |
| publishDate | 2003 |
| publisher.none.fl_str_mv | Sociedade Brasileira de Química |
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| spelling | Antimoniais empregados no tratamento da leishmaniose: estado da arteRath,SusanneTrivelin,Luciano AugustoImbrunito,Talitha RebeccaTomazela,Daniela MariaJesús,Marcelo Nunes deMarzal,Percy CalvoAndrade Junior,Heitor Franco deTempone,André Gustavoantimonyleishmaniasistherapyopen accesshttp://purl.org/coar/access_right/c_abf2http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000400018URLhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000400018URLHasVersion2003-08-01Antimony preparations are the drugs of choice for the treatment of leishmaniasis over 90 years, a disease that currently affects 12 million people worldwide. Its introduction was based on 19th century concepts of therapeutic effects of metal salts as arsenicals and other metals, most of them abandoned due to toxic effects or better drugs. In the last three decades, there was a great improvement in the knowledge of cell biology and immunology of those infections, but chemotherapy has not been improved in the same strength. The structure and mechanism of action of the two pentavalent antimonial drugs of choice, meglumine antimoniate and sodium stibogluconate, are not well known and the contamination of those pharmaceutical by toxic contaminants have been verified.portext/htmlSociedade Brasileira de QuímicaQuímica Nova v.26 n.4 2003reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Antimoniais empregados no tratamento da leishmaniose: estado da arte Rath,Susanne antimony leishmaniasis therapy |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | antimony leishmaniasis therapy |
| title | Antimoniais empregados no tratamento da leishmaniose: estado da arte |
| title_full | Antimoniais empregados no tratamento da leishmaniose: estado da arte |
| title_fullStr | Antimoniais empregados no tratamento da leishmaniose: estado da arte |
| title_full_unstemmed | Antimoniais empregados no tratamento da leishmaniose: estado da arte |
| title_short | Antimoniais empregados no tratamento da leishmaniose: estado da arte |
| title_sort | Antimoniais empregados no tratamento da leishmaniose: estado da arte |
| topic | antimony leishmaniasis therapy |
| topic_facet | antimony leishmaniasis therapy |
| url | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422003000400018 |
| visible | 1 |
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