Publicação
Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats
| Resumo: | In recent years all over the world, medicinal plants are used quite a lot but side effects of biological and chemical contents and radiopharmaceutical interactions for each consumer in question aren't entirely well-known. The studies of plant origin drug interaction with radiopharmaceuticals are highly relevant and desired. One of them is passiflora syrup (Passiflora incarnata L., Passifloraceae) which is widely used for depression, insomnia, anxiety and menopause period. The aim of current study is to evaluate possible effects of passiflora syrup on the biodistribution of 99mTc-DTPA and its blood cells uptake. DTPA was labeled with 99mTc radionuclide. Biodistribution studies were performed on male Wistar albino rats which were treated via oral feeding-gavage-method with either passiflora syrup or 0.9 % NaCl as control group for ten days. Blood samples were obtained by cardiac blood withdrawal from the rats and they were radiolabeled. The biodistribution results showed that the passiflora syrup decreased the uptake of 99mTc-DTPA in kidneys and in blood cells. 99mTc-DTPA being used widely as a kidney diagnostic agent in nuclear medicine seems to be interacting with orally taken passiflora. Passiflora syrup may modify the uptake of 99mTc-DTPA by kidney. The knowledge of this negative effect may contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine. |
|---|---|
| Autores principais: | Zora,Hasan |
| Outros Autores: | Muftuler,Zumrut F. Biber; Demir,Ilknur; Kilcar,Ayfer Yurt; Ichedef,Cigdem; Unak,Perihan |
| Assunto: | blood cells biodistribution drug interaction Passiflora syrup 99mTc-DTPA Wistar albino rat |
| Ano: | 2012 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| _version_ | 1871507363188441088 |
|---|---|
| author | Zora,Hasan |
| author2 | Muftuler,Zumrut F. Biber Demir,Ilknur Kilcar,Ayfer Yurt Ichedef,Cigdem Unak,Perihan |
| author2_role | author author author author author |
| author_facet | Zora,Hasan Muftuler,Zumrut F. Biber Demir,Ilknur Kilcar,Ayfer Yurt Ichedef,Cigdem Unak,Perihan |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Zora,Hasan\"},{\"Person.name\":\"Muftuler,Zumrut F. Biber\"},{\"Person.name\":\"Demir,Ilknur\"},{\"Person.name\":\"Kilcar,Ayfer Yurt\"},{\"Person.name\":\"Ichedef,Cigdem\"},{\"Person.name\":\"Unak,Perihan\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Zora,Hasan Muftuler,Zumrut F. Biber Demir,Ilknur Kilcar,Ayfer Yurt Ichedef,Cigdem Unak,Perihan |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | blood cells biodistribution drug interaction Passiflora syrup 99mTc-DTPA Wistar albino rat |
| datacite.titles.title.fl_str_mv | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats |
| dc.creator.none.fl_str_mv | Zora,Hasan Muftuler,Zumrut F. Biber Demir,Ilknur Kilcar,Ayfer Yurt Ichedef,Cigdem Unak,Perihan |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000200014 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Brasileira de Farmacognosia |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Revista Brasileira de Farmacognosia v.22 n.2 2012 reponame:Revista Brasileira de Farmacognosia (Online) instname:Sociedade Brasileira de Farmacognosia (SBFgnosia) instacron:SBFGNOSIA |
| dc.subject.none.fl_str_mv | blood cells biodistribution drug interaction Passiflora syrup 99mTc-DTPA Wistar albino rat |
| dc.title.fl_str_mv | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | In recent years all over the world, medicinal plants are used quite a lot but side effects of biological and chemical contents and radiopharmaceutical interactions for each consumer in question aren't entirely well-known. The studies of plant origin drug interaction with radiopharmaceuticals are highly relevant and desired. One of them is passiflora syrup (Passiflora incarnata L., Passifloraceae) which is widely used for depression, insomnia, anxiety and menopause period. The aim of current study is to evaluate possible effects of passiflora syrup on the biodistribution of 99mTc-DTPA and its blood cells uptake. DTPA was labeled with 99mTc radionuclide. Biodistribution studies were performed on male Wistar albino rats which were treated via oral feeding-gavage-method with either passiflora syrup or 0.9 % NaCl as control group for ten days. Blood samples were obtained by cardiac blood withdrawal from the rats and they were radiolabeled. The biodistribution results showed that the passiflora syrup decreased the uptake of 99mTc-DTPA in kidneys and in blood cells. 99mTc-DTPA being used widely as a kidney diagnostic agent in nuclear medicine seems to be interacting with orally taken passiflora. Passiflora syrup may modify the uptake of 99mTc-DTPA by kidney. The knowledge of this negative effect may contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine. |
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| language | eng |
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| person_str_mv | Zora,Hasan Muftuler,Zumrut F. Biber Demir,Ilknur Kilcar,Ayfer Yurt Ichedef,Cigdem Unak,Perihan |
| publishDate | 2012 |
| publisher.none.fl_str_mv | Sociedade Brasileira de Farmacognosia |
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| spelling | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino ratsZora,HasanMuftuler,Zumrut F. BiberDemir,IlknurKilcar,Ayfer YurtIchedef,CigdemUnak,Perihanblood cellsbiodistributiondrug interactionPassiflora syrup99mTc-DTPAWistar albino ratopen accesshttp://purl.org/coar/access_right/c_abf2http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000200014URLhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000200014URLHasVersion2012-04-01In recent years all over the world, medicinal plants are used quite a lot but side effects of biological and chemical contents and radiopharmaceutical interactions for each consumer in question aren't entirely well-known. The studies of plant origin drug interaction with radiopharmaceuticals are highly relevant and desired. One of them is passiflora syrup (Passiflora incarnata L., Passifloraceae) which is widely used for depression, insomnia, anxiety and menopause period. The aim of current study is to evaluate possible effects of passiflora syrup on the biodistribution of 99mTc-DTPA and its blood cells uptake. DTPA was labeled with 99mTc radionuclide. Biodistribution studies were performed on male Wistar albino rats which were treated via oral feeding-gavage-method with either passiflora syrup or 0.9 % NaCl as control group for ten days. Blood samples were obtained by cardiac blood withdrawal from the rats and they were radiolabeled. The biodistribution results showed that the passiflora syrup decreased the uptake of 99mTc-DTPA in kidneys and in blood cells. 99mTc-DTPA being used widely as a kidney diagnostic agent in nuclear medicine seems to be interacting with orally taken passiflora. Passiflora syrup may modify the uptake of 99mTc-DTPA by kidney. The knowledge of this negative effect may contribute to reduce the risk of misdiagnosis and/or repetition of the examinations in nuclear medicine.engtext/htmlSociedade Brasileira de FarmacognosiaRevista Brasileira de Farmacognosia v.22 n.2 2012reponame:Revista Brasileira de Farmacognosia (Online)instname:Sociedade Brasileira de Farmacognosia (SBFgnosia)instacron:SBFGNOSIAjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats Zora,Hasan blood cells biodistribution drug interaction Passiflora syrup 99mTc-DTPA Wistar albino rat |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | blood cells biodistribution drug interaction Passiflora syrup 99mTc-DTPA Wistar albino rat |
| title | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats |
| title_full | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats |
| title_fullStr | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats |
| title_full_unstemmed | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats |
| title_short | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats |
| title_sort | Effect of a plant origin drug on the biodistribution of 99mTc-DTPA in Wistar albino rats |
| topic | blood cells biodistribution drug interaction Passiflora syrup 99mTc-DTPA Wistar albino rat |
| topic_facet | blood cells biodistribution drug interaction Passiflora syrup 99mTc-DTPA Wistar albino rat |
| url | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2012000200014 |
| visible | 1 |
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