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Ozonized solutions favor the repair of experimentally induced skin wounds in rats

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Summary:ABSTRACT: This study aimed to evaluate and compare the effects of ozonized solutions on tissue wound repair in rats. Treatments consisted of ozonized water (GA), 0.9% sodium chloride (GCL), ozonized oil (GO), and 0.2% allantoin cream (GAL). The morphometric evaluation showed that wounds of the GA group presented a higher degree of retraction (p<0.05) at three and eight days of treatment (37.96 and 84.81%, respectively). Picrosirius red staining showed that groups GA and GO presented higher deposition (p<0.05) of type I collagen at 15 and 22 days of treatment, respectively. The neovascularization was higher in wounds of group GO on days 3, 8, and 15 (p<0.05), with higher VEGF immunostaining. (p<0.05). Thus, ozonized water enhances wound retraction and assists in the maturation and remodeling phase, while ozonized oil promotes higher neovascularization during tissue repair and higher deposition of type I collagen from the third week of treatment.
Main Authors:Sanguanini,Rafael C.
Other Authors:Bento,Mariana F.; Oliveira,Evelyn de; Arnhold,Emmanuel; Faleiro,Mariana B.R.; Franco,Leandro G.; Matos,Moema P.C.; Moura,Veridiana Maria B.D.
Subject:Ozonized water wound healing ozonized oil ozone therapy skin wounds rats
Year:2020
Country:Brazil
Document type:article
Access type:open access
Associated institution:IBICT
Language:English
Origin:Oasisbr

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