Publication
Ozonized solutions favor the repair of experimentally induced skin wounds in rats
| Summary: | ABSTRACT: This study aimed to evaluate and compare the effects of ozonized solutions on tissue wound repair in rats. Treatments consisted of ozonized water (GA), 0.9% sodium chloride (GCL), ozonized oil (GO), and 0.2% allantoin cream (GAL). The morphometric evaluation showed that wounds of the GA group presented a higher degree of retraction (p<0.05) at three and eight days of treatment (37.96 and 84.81%, respectively). Picrosirius red staining showed that groups GA and GO presented higher deposition (p<0.05) of type I collagen at 15 and 22 days of treatment, respectively. The neovascularization was higher in wounds of group GO on days 3, 8, and 15 (p<0.05), with higher VEGF immunostaining. (p<0.05). Thus, ozonized water enhances wound retraction and assists in the maturation and remodeling phase, while ozonized oil promotes higher neovascularization during tissue repair and higher deposition of type I collagen from the third week of treatment. |
|---|---|
| Main Authors: | Sanguanini,Rafael C. |
| Other Authors: | Bento,Mariana F.; Oliveira,Evelyn de; Arnhold,Emmanuel; Faleiro,Mariana B.R.; Franco,Leandro G.; Matos,Moema P.C.; Moura,Veridiana Maria B.D. |
| Subject: | Ozonized water wound healing ozonized oil ozone therapy skin wounds rats |
| Year: | 2020 |
| Country: | Brazil |
| Document type: | article |
| Access type: | open access |
| Associated institution: | IBICT |
| Language: | English |
| Origin: | Oasisbr |
| _version_ | 1871509071158312960 |
|---|---|
| author | Sanguanini,Rafael C. |
| author2 | Bento,Mariana F. Oliveira,Evelyn de Arnhold,Emmanuel Faleiro,Mariana B.R. Franco,Leandro G. Matos,Moema P.C. Moura,Veridiana Maria B.D. |
| author2_role | author author author author author author author |
| author_facet | Sanguanini,Rafael C. Bento,Mariana F. Oliveira,Evelyn de Arnhold,Emmanuel Faleiro,Mariana B.R. Franco,Leandro G. Matos,Moema P.C. Moura,Veridiana Maria B.D. |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Sanguanini,Rafael C.\"},{\"Person.name\":\"Bento,Mariana F.\"},{\"Person.name\":\"Oliveira,Evelyn de\"},{\"Person.name\":\"Arnhold,Emmanuel\"},{\"Person.name\":\"Faleiro,Mariana B.R.\"},{\"Person.name\":\"Franco,Leandro G.\"},{\"Person.name\":\"Matos,Moema P.C.\"},{\"Person.name\":\"Moura,Veridiana Maria B.D.\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Sanguanini,Rafael C. Bento,Mariana F. Oliveira,Evelyn de Arnhold,Emmanuel Faleiro,Mariana B.R. Franco,Leandro G. Matos,Moema P.C. Moura,Veridiana Maria B.D. |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Ozonized water wound healing ozonized oil ozone therapy skin wounds rats |
| datacite.titles.title.fl_str_mv | Ozonized solutions favor the repair of experimentally induced skin wounds in rats |
| dc.creator.none.fl_str_mv | Sanguanini,Rafael C. Bento,Mariana F. Oliveira,Evelyn de Arnhold,Emmanuel Faleiro,Mariana B.R. Franco,Leandro G. Matos,Moema P.C. Moura,Veridiana Maria B.D. |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020001100914 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Colégio Brasileiro de Patologia Animal - CBPA |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Pesquisa Veterinária Brasileira v.40 n.11 2020 reponame:Pesquisa Veterinária Brasileira (Online) instname:Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA |
| dc.subject.none.fl_str_mv | Ozonized water wound healing ozonized oil ozone therapy skin wounds rats |
| dc.title.fl_str_mv | Ozonized solutions favor the repair of experimentally induced skin wounds in rats |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | ABSTRACT: This study aimed to evaluate and compare the effects of ozonized solutions on tissue wound repair in rats. Treatments consisted of ozonized water (GA), 0.9% sodium chloride (GCL), ozonized oil (GO), and 0.2% allantoin cream (GAL). The morphometric evaluation showed that wounds of the GA group presented a higher degree of retraction (p<0.05) at three and eight days of treatment (37.96 and 84.81%, respectively). Picrosirius red staining showed that groups GA and GO presented higher deposition (p<0.05) of type I collagen at 15 and 22 days of treatment, respectively. The neovascularization was higher in wounds of group GO on days 3, 8, and 15 (p<0.05), with higher VEGF immunostaining. (p<0.05). Thus, ozonized water enhances wound retraction and assists in the maturation and remodeling phase, while ozonized oil promotes higher neovascularization during tissue repair and higher deposition of type I collagen from the third week of treatment. |
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| eu_rights_str_mv | openAccess |
| format | article |
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| identifier.url.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020001100914 |
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| instacron_str | OASISBR |
| institution | IBICT |
| instname_str | IBICT |
| language | eng |
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| person_str_mv | Sanguanini,Rafael C. Bento,Mariana F. Oliveira,Evelyn de Arnhold,Emmanuel Faleiro,Mariana B.R. Franco,Leandro G. Matos,Moema P.C. Moura,Veridiana Maria B.D. |
| publishDate | 2020 |
| publisher.none.fl_str_mv | Colégio Brasileiro de Patologia Animal - CBPA |
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| spelling | Ozonized solutions favor the repair of experimentally induced skin wounds in ratsSanguanini,Rafael C.Bento,Mariana F.Oliveira,Evelyn deArnhold,EmmanuelFaleiro,Mariana B.R.Franco,Leandro G.Matos,Moema P.C.Moura,Veridiana Maria B.D.Ozonized waterwound healingozonized oilozone therapyskin woundsratsopen accesshttp://purl.org/coar/access_right/c_abf2http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020001100914URLhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020001100914URLHasVersion2020-11-01ABSTRACT: This study aimed to evaluate and compare the effects of ozonized solutions on tissue wound repair in rats. Treatments consisted of ozonized water (GA), 0.9% sodium chloride (GCL), ozonized oil (GO), and 0.2% allantoin cream (GAL). The morphometric evaluation showed that wounds of the GA group presented a higher degree of retraction (p<0.05) at three and eight days of treatment (37.96 and 84.81%, respectively). Picrosirius red staining showed that groups GA and GO presented higher deposition (p<0.05) of type I collagen at 15 and 22 days of treatment, respectively. The neovascularization was higher in wounds of group GO on days 3, 8, and 15 (p<0.05), with higher VEGF immunostaining. (p<0.05). Thus, ozonized water enhances wound retraction and assists in the maturation and remodeling phase, while ozonized oil promotes higher neovascularization during tissue repair and higher deposition of type I collagen from the third week of treatment.engtext/htmlColégio Brasileiro de Patologia Animal - CBPAPesquisa Veterinária Brasileira v.40 n.11 2020reponame:Pesquisa Veterinária Brasileira (Online)instname:Colégio Brasileiro de Patologia Animal (CBPA)instacron:EMBRAPAjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Ozonized solutions favor the repair of experimentally induced skin wounds in rats Sanguanini,Rafael C. Ozonized water wound healing ozonized oil ozone therapy skin wounds rats |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | Ozonized water wound healing ozonized oil ozone therapy skin wounds rats |
| title | Ozonized solutions favor the repair of experimentally induced skin wounds in rats |
| title_full | Ozonized solutions favor the repair of experimentally induced skin wounds in rats |
| title_fullStr | Ozonized solutions favor the repair of experimentally induced skin wounds in rats |
| title_full_unstemmed | Ozonized solutions favor the repair of experimentally induced skin wounds in rats |
| title_short | Ozonized solutions favor the repair of experimentally induced skin wounds in rats |
| title_sort | Ozonized solutions favor the repair of experimentally induced skin wounds in rats |
| topic | Ozonized water wound healing ozonized oil ozone therapy skin wounds rats |
| topic_facet | Ozonized water wound healing ozonized oil ozone therapy skin wounds rats |
| url | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-736X2020001100914 |
| visible | 1 |
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