Publication
Action of ascorbic acid on the healing of malnourished rats'skin wounds
| Summary: | Objective: To evaluate the action of ascorbic acid on the healing of malnourished rats' cutaneous wounds compared with normal weight rats. Methods: We used 92 adult, male Wistar rats divided into four groups: 24 normal weight rats given only water and chow; 24 normal weight rats given vitamin C by gavage (340 mg/kg 12/12 hours); 22 malnourished rats given only water and chow; and 22 malnourished rats given vitamin C by gavage (340 mg/kg 12/12 hours). Malnutrition was induced by feeding the animals half of their daily energy requirement for 30 days. Two incisions were made, one sutured (healing by primary intention) and one left unsutured (healing by secondary intention). The rats were euthanized on the third, seventh, and fourteenth days of the experiment. Results: The following parameters differed significantly between the groups (p>0.05): granulation of the wound edge in the primary and secondary intention; extent of injuries on day 7 for primary intention and on day 3 for secondary intention; reepithelialization on day 7 for primary intention; fibrin-leukocyte scab on day 14 for primary intention; amount of neovascularization and concentration of macrophages, fibroblasts, and collagen fibers for primary and secondary intention. Conclusion: The use of vitamin C in malnourished and normal weight rats increases fibroblast proliferation and collagen deposition in the tissue, which helps to improve healing both by primary and secondary intention. |
|---|---|
| Main Authors: | Nai,Gisele Alborghetti |
| Other Authors: | Manzoli,Louise Maria Freitas; SILVA,Tayane Carvalho Isidoro da; Mamede,Larissa de Queiroz; Disconzi,Mary Ellen de Oliveira Martins; Giuffrida,Rogério |
| Subject: | Ascorbic acid Malnutrition Skin Vitamins Wound healing |
| Year: | 2014 |
| Country: | Brazil |
| Document type: | article |
| Access type: | open access |
| Associated institution: | IBICT |
| Language: | English |
| Origin: | Oasisbr |
| _version_ | 1871508393772974080 |
|---|---|
| author | Nai,Gisele Alborghetti |
| author2 | Manzoli,Louise Maria Freitas SILVA,Tayane Carvalho Isidoro da Mamede,Larissa de Queiroz Disconzi,Mary Ellen de Oliveira Martins Giuffrida,Rogério |
| author2_role | author author author author author |
| author_facet | Nai,Gisele Alborghetti Manzoli,Louise Maria Freitas SILVA,Tayane Carvalho Isidoro da Mamede,Larissa de Queiroz Disconzi,Mary Ellen de Oliveira Martins Giuffrida,Rogério |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Nai,Gisele Alborghetti\"},{\"Person.name\":\"Manzoli,Louise Maria Freitas\"},{\"Person.name\":\"SILVA,Tayane Carvalho Isidoro da\"},{\"Person.name\":\"Mamede,Larissa de Queiroz\"},{\"Person.name\":\"Disconzi,Mary Ellen de Oliveira Martins\"},{\"Person.name\":\"Giuffrida,Rogério\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Nai,Gisele Alborghetti Manzoli,Louise Maria Freitas SILVA,Tayane Carvalho Isidoro da Mamede,Larissa de Queiroz Disconzi,Mary Ellen de Oliveira Martins Giuffrida,Rogério |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Ascorbic acid Malnutrition Skin Vitamins Wound healing |
| datacite.titles.title.fl_str_mv | Action of ascorbic acid on the healing of malnourished rats'skin wounds |
| dc.creator.none.fl_str_mv | Nai,Gisele Alborghetti Manzoli,Louise Maria Freitas SILVA,Tayane Carvalho Isidoro da Mamede,Larissa de Queiroz Disconzi,Mary Ellen de Oliveira Martins Giuffrida,Rogério |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732014000400459 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Pontifícia Universidade Católica de Campinas |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Revista de Nutrição v.27 n.4 2014 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
| dc.subject.none.fl_str_mv | Ascorbic acid Malnutrition Skin Vitamins Wound healing |
| dc.title.fl_str_mv | Action of ascorbic acid on the healing of malnourished rats'skin wounds |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Objective: To evaluate the action of ascorbic acid on the healing of malnourished rats' cutaneous wounds compared with normal weight rats. Methods: We used 92 adult, male Wistar rats divided into four groups: 24 normal weight rats given only water and chow; 24 normal weight rats given vitamin C by gavage (340 mg/kg 12/12 hours); 22 malnourished rats given only water and chow; and 22 malnourished rats given vitamin C by gavage (340 mg/kg 12/12 hours). Malnutrition was induced by feeding the animals half of their daily energy requirement for 30 days. Two incisions were made, one sutured (healing by primary intention) and one left unsutured (healing by secondary intention). The rats were euthanized on the third, seventh, and fourteenth days of the experiment. Results: The following parameters differed significantly between the groups (p>0.05): granulation of the wound edge in the primary and secondary intention; extent of injuries on day 7 for primary intention and on day 3 for secondary intention; reepithelialization on day 7 for primary intention; fibrin-leukocyte scab on day 14 for primary intention; amount of neovascularization and concentration of macrophages, fibroblasts, and collagen fibers for primary and secondary intention. Conclusion: The use of vitamin C in malnourished and normal weight rats increases fibroblast proliferation and collagen deposition in the tissue, which helps to improve healing both by primary and secondary intention. |
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| identifier.url.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732014000400459 |
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| language | eng |
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| person_str_mv | Nai,Gisele Alborghetti Manzoli,Louise Maria Freitas SILVA,Tayane Carvalho Isidoro da Mamede,Larissa de Queiroz Disconzi,Mary Ellen de Oliveira Martins Giuffrida,Rogério |
| publishDate | 2014 |
| publisher.none.fl_str_mv | Pontifícia Universidade Católica de Campinas |
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| spelling | Action of ascorbic acid on the healing of malnourished rats'skin woundsNai,Gisele AlborghettiManzoli,Louise Maria FreitasSILVA,Tayane Carvalho Isidoro daMamede,Larissa de QueirozDisconzi,Mary Ellen de Oliveira MartinsGiuffrida,RogérioAscorbic acidMalnutritionSkinVitaminsWound healingopen accesshttp://purl.org/coar/access_right/c_abf2http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732014000400459URLhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732014000400459URLHasVersion2014-08-01Objective: To evaluate the action of ascorbic acid on the healing of malnourished rats' cutaneous wounds compared with normal weight rats. Methods: We used 92 adult, male Wistar rats divided into four groups: 24 normal weight rats given only water and chow; 24 normal weight rats given vitamin C by gavage (340 mg/kg 12/12 hours); 22 malnourished rats given only water and chow; and 22 malnourished rats given vitamin C by gavage (340 mg/kg 12/12 hours). Malnutrition was induced by feeding the animals half of their daily energy requirement for 30 days. Two incisions were made, one sutured (healing by primary intention) and one left unsutured (healing by secondary intention). The rats were euthanized on the third, seventh, and fourteenth days of the experiment. Results: The following parameters differed significantly between the groups (p>0.05): granulation of the wound edge in the primary and secondary intention; extent of injuries on day 7 for primary intention and on day 3 for secondary intention; reepithelialization on day 7 for primary intention; fibrin-leukocyte scab on day 14 for primary intention; amount of neovascularization and concentration of macrophages, fibroblasts, and collagen fibers for primary and secondary intention. Conclusion: The use of vitamin C in malnourished and normal weight rats increases fibroblast proliferation and collagen deposition in the tissue, which helps to improve healing both by primary and secondary intention.engtext/htmlPontifícia Universidade Católica de CampinasRevista de Nutrição v.27 n.4 2014reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Action of ascorbic acid on the healing of malnourished rats'skin wounds Nai,Gisele Alborghetti Ascorbic acid Malnutrition Skin Vitamins Wound healing |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | Ascorbic acid Malnutrition Skin Vitamins Wound healing |
| title | Action of ascorbic acid on the healing of malnourished rats'skin wounds |
| title_full | Action of ascorbic acid on the healing of malnourished rats'skin wounds |
| title_fullStr | Action of ascorbic acid on the healing of malnourished rats'skin wounds |
| title_full_unstemmed | Action of ascorbic acid on the healing of malnourished rats'skin wounds |
| title_short | Action of ascorbic acid on the healing of malnourished rats'skin wounds |
| title_sort | Action of ascorbic acid on the healing of malnourished rats'skin wounds |
| topic | Ascorbic acid Malnutrition Skin Vitamins Wound healing |
| topic_facet | Ascorbic acid Malnutrition Skin Vitamins Wound healing |
| url | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732014000400459 |
| visible | 1 |
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