Publicação
Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis
| Resumo: | Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: 4921530L21Rik and Gm13931) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication. |
|---|---|
| Autores principais: | Yeo,Sujung |
| Outros Autores: | An,Keon Sang; Hong,Yeon-Mi; Choi,Yeong-Gon; Rosen,Bruce; Kim,Sung-Hoon; Lim,Sabina |
| Assunto: | Parkinson’s disease gene array differentially expressed genes neurodegeneration acupoints |
| Ano: | 2015 |
| País: | Brasil |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | IBICT |
| Idioma: | inglês |
| Origem: | Oasisbr |
| _version_ | 1871507294835965952 |
|---|---|
| author | Yeo,Sujung |
| author2 | An,Keon Sang Hong,Yeon-Mi Choi,Yeong-Gon Rosen,Bruce Kim,Sung-Hoon Lim,Sabina |
| author2_role | author author author author author author |
| author_facet | Yeo,Sujung An,Keon Sang Hong,Yeon-Mi Choi,Yeong-Gon Rosen,Bruce Kim,Sung-Hoon Lim,Sabina |
| author_role | author |
| country_str | BR |
| creators_json_txt | [{\"Person.name\":\"Yeo,Sujung\"},{\"Person.name\":\"An,Keon Sang\"},{\"Person.name\":\"Hong,Yeon-Mi\"},{\"Person.name\":\"Choi,Yeong-Gon\"},{\"Person.name\":\"Rosen,Bruce\"},{\"Person.name\":\"Kim,Sung-Hoon\"},{\"Person.name\":\"Lim,Sabina\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Yeo,Sujung An,Keon Sang Hong,Yeon-Mi Choi,Yeong-Gon Rosen,Bruce Kim,Sung-Hoon Lim,Sabina |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Parkinson’s disease gene array differentially expressed genes neurodegeneration acupoints |
| datacite.titles.title.fl_str_mv | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis |
| dc.creator.none.fl_str_mv | Yeo,Sujung An,Keon Sang Hong,Yeon-Mi Choi,Yeong-Gon Rosen,Bruce Kim,Sung-Hoon Lim,Sabina |
| dc.format.none.fl_str_mv | text/html |
| dc.identifier.none.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100115 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Sociedade Brasileira de Genética |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Genetics and Molecular Biology v.38 n.1 2015 reponame:Genetics and Molecular Biology instname:Sociedade Brasileira de Genética (SBG) instacron:SBG |
| dc.subject.none.fl_str_mv | Parkinson’s disease gene array differentially expressed genes neurodegeneration acupoints |
| dc.title.fl_str_mv | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: 4921530L21Rik and Gm13931) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
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| identifier.url.fl_str_mv | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100115 |
| inst_facet_str | urn:organizationAcronym:oasisbr{{{_:::_}}}IBICT |
| instacron_str | OASISBR |
| institution | IBICT |
| instname_str | IBICT |
| language | eng |
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| network_name_str | Oasisbr |
| oai_identifier_str | oai:scielo:S1415-47572015000100115 |
| organization_str_mv | urn:organizationAcronym:oasisbr |
| person_str_mv | Yeo,Sujung An,Keon Sang Hong,Yeon-Mi Choi,Yeong-Gon Rosen,Bruce Kim,Sung-Hoon Lim,Sabina |
| publishDate | 2015 |
| publisher.none.fl_str_mv | Sociedade Brasileira de Genética |
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| spelling | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysisYeo,SujungAn,Keon SangHong,Yeon-MiChoi,Yeong-GonRosen,BruceKim,Sung-HoonLim,SabinaParkinson’s diseasegene arraydifferentially expressed genesneurodegenerationacupointsopen accesshttp://purl.org/coar/access_right/c_abf2http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100115URLhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100115URLHasVersion2015-03-01Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated changes in gene expression profiles measured using whole transcript array in the SN region related to the inhibitory effects of acupuncture in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) Parkinsonism model. In this model, acupuncture stimulation at GB34 and LR3 attenuated the decrease in tyrosine hydroxylase in the SN region; stimulation at non-acupoints did not suppress this decrease. Gene array analysis revealed that 22 (10 annotated genes: Cdh1, Itih2, Mpzl2, Rdh9, Serping1, Slc6a13, Slc6a20a, Slc6a4, Tph2, and Ucma) probes that were up-regulated in MPTP animals relative to controls were exclusively down-regulated by acupuncture stimulation. In addition, 17 (two annotated genes: 4921530L21Rik and Gm13931) probes that were down-regulated in MPTP animals compared to controls were exclusively up-regulated by acupuncture stimulation. These findings indicate that the 39 probes (12 annotated genes) affected by MPTP and acupuncture may be responsible for the inhibitory effects of acupuncture on degeneration-related gene expression in the SN following damage induced by MPTP intoxication.engtext/htmlSociedade Brasileira de GenéticaGenetics and Molecular Biology v.38 n.1 2015reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBGjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85 |
| spellingShingle | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis Yeo,Sujung Parkinson’s disease gene array differentially expressed genes neurodegeneration acupoints |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | Parkinson’s disease gene array differentially expressed genes neurodegeneration acupoints |
| title | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis |
| title_full | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis |
| title_fullStr | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis |
| title_full_unstemmed | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis |
| title_short | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis |
| title_sort | Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis |
| topic | Parkinson’s disease gene array differentially expressed genes neurodegeneration acupoints |
| topic_facet | Parkinson’s disease gene array differentially expressed genes neurodegeneration acupoints |
| url | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572015000100115 |
| visible | 1 |
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