Publicação
Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel
| Resumo: | Axial migration of individual red blood cells (RBCs) is a well known effect that happens in microchannels with dimensions below 300 μm. This effect is known as the Fåhræus-Lindqvist effect gives place to a cell free layer (CFL) of plasma located around the walls of the microchannel [1]. Several flow studies regarding the CFL measurement exist in in vitro [1-3] environments. However, the manipulation of in vitro blood is often difficult due to the ethical, economical and safety issues involved. As a result, the development of blood analogue solutions is needed to improve our understanding regarding the blood flow behaviour in microchannels and microvessels. Although several studies using one-phase Newtonian and non-Newtonian blood analogues can be found in the literature [4, 5], there are few works related with the use of particulate solutions in which the particles mimic the RBCs behaviour. The present work proposes a particulate-viscoelastic solution made of xanthan gum and dextran with rigid polymethylmethacrylate (PMMA) spherical particles able to mimic the effect of CFL formation that frequently happens in in vitro blood flow systems. Flow visualizations through hyperbolic contraction microchannels were used to observe the CFL originated by the proposed blood analogue fluid. Additionally, this CFL was compared with the plasma layer formed by an in vitro blood sample. |
|---|---|
| Autores principais: | Calejo, Joana A.C. |
| Outros Autores: | Pinho, Diana; Garcia, Valdemar; Galindo-Rosales, Francisco J.; Lima, Rui A.; Campo-Deaño, Laura |
| Assunto: | Blood analogue fluid PMMA Hyperbolic microchannel |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | documento de conferência |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade Politécnica de Bragança |
| Idioma: | inglês |
| Origem: | Biblioteca Digital da UPB |
| _version_ | 1877782473309421568 |
|---|---|
| author | Calejo, Joana A.C. |
| author2 | Pinho, Diana Garcia, Valdemar Galindo-Rosales, Francisco J. Lima, Rui A. Campo-Deaño, Laura |
| author2_role | author author author author author |
| author_facet | Calejo, Joana A.C. Pinho, Diana Garcia, Valdemar Galindo-Rosales, Francisco J. Lima, Rui A. Campo-Deaño, Laura |
| author_role | author |
| contributor_name_str_mv | Biblioteca Digital da UPB |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Calejo, Joana A.C.\"},{\"Person.name\":\"Pinho, Diana\",\"Person.identifier.cienciaID\":\"5214-ED0C-35E8\",\"Person.identifier.orcid\":\"0000-0002-3884-6496\"},{\"Person.name\":\"Garcia, Valdemar\",\"Person.identifier.orcid\":\"0000-0002-3941-2438\"},{\"Person.name\":\"Galindo-Rosales, Francisco J.\"},{\"Person.name\":\"Lima, Rui A.\",\"Person.identifier.cienciaID\":\"EE12-C3FB-349D\",\"Person.identifier.orcid\":\"0000-0003-3428-637X\",\"Person.identifier.researcherID\":\"H-5157-2016\",\"Person.identifier.scopusAuthorID\":\"18437397800\"},{\"Person.name\":\"Campo-Deaño, Laura\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Biblioteca Digital da UPB |
| datacite.creators.creator.creatorName.fl_str_mv | Calejo, Joana A.C. Pinho, Diana Garcia, Valdemar Galindo-Rosales, Francisco J. Lima, Rui A. Campo-Deaño, Laura |
| datacite.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2018-02-20T11:43:23Z |
| datacite.date.embargoed.fl_str_mv | 2018-02-20T11:43:23Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Blood analogue fluid PMMA Hyperbolic microchannel |
| datacite.titles.title.fl_str_mv | Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel |
| dc.contributor.none.fl_str_mv | Biblioteca Digital da UPB |
| dc.creator.none.fl_str_mv | Calejo, Joana A.C. Pinho, Diana Garcia, Valdemar Galindo-Rosales, Francisco J. Lima, Rui A. Campo-Deaño, Laura |
| dc.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2018-02-20T11:43:23Z |
| dc.date.embargoed.fl_str_mv | 2018-02-20T11:43:23Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10198/15830 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Instituto Politécnico de Bragança |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Blood analogue fluid PMMA Hyperbolic microchannel |
| dc.title.fl_str_mv | Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_c94f |
| description | Axial migration of individual red blood cells (RBCs) is a well known effect that happens in microchannels with dimensions below 300 μm. This effect is known as the Fåhræus-Lindqvist effect gives place to a cell free layer (CFL) of plasma located around the walls of the microchannel [1]. Several flow studies regarding the CFL measurement exist in in vitro [1-3] environments. However, the manipulation of in vitro blood is often difficult due to the ethical, economical and safety issues involved. As a result, the development of blood analogue solutions is needed to improve our understanding regarding the blood flow behaviour in microchannels and microvessels. Although several studies using one-phase Newtonian and non-Newtonian blood analogues can be found in the literature [4, 5], there are few works related with the use of particulate solutions in which the particles mimic the RBCs behaviour. The present work proposes a particulate-viscoelastic solution made of xanthan gum and dextran with rigid polymethylmethacrylate (PMMA) spherical particles able to mimic the effect of CFL formation that frequently happens in in vitro blood flow systems. Flow visualizations through hyperbolic contraction microchannels were used to observe the CFL originated by the proposed blood analogue fluid. Additionally, this CFL was compared with the plasma layer formed by an in vitro blood sample. |
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| eu_rights_str_mv | openAccess |
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| funding.funder.alternateName_str_mv | FCT FCT |
| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia Fundação para a Ciência e a Tecnologia |
| funding.identifier_str_mv | PTDC/SAU-ENB/116929/2010 SFRH/BD/89077/2012 |
| funding.name_str_mv | 5876-PPCDTI SFRH |
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| language | eng |
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| person_str_mv | Calejo, Joana A.C. Pinho, Diana Pinho, Diana https://www.ciencia-id.pt/5214-ED0C-35E8 5214-ED0C-35E8 http://orcid.org/0000-0002-3884-6496 0000-0002-3884-6496 Garcia, Valdemar Garcia, Valdemar http://orcid.org/0000-0002-3941-2438 0000-0002-3941-2438 Galindo-Rosales, Francisco J. Lima, Rui A. Lima, Rui A. https://www.ciencia-id.pt/EE12-C3FB-349D EE12-C3FB-349D http://orcid.org/0000-0003-3428-637X 0000-0003-3428-637X Campo-Deaño, Laura |
| publishDate | 2015 |
| publisher.none.fl_str_mv | Instituto Politécnico de Bragança |
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| spelling | engInstituto Politécnico de Bragançapt_PTAxial migration of individual red blood cells (RBCs) is a well known effect that happens in microchannels with dimensions below 300 μm. This effect is known as the Fåhræus-Lindqvist effect gives place to a cell free layer (CFL) of plasma located around the walls of the microchannel [1]. Several flow studies regarding the CFL measurement exist in in vitro [1-3] environments. However, the manipulation of in vitro blood is often difficult due to the ethical, economical and safety issues involved. As a result, the development of blood analogue solutions is needed to improve our understanding regarding the blood flow behaviour in microchannels and microvessels. Although several studies using one-phase Newtonian and non-Newtonian blood analogues can be found in the literature [4, 5], there are few works related with the use of particulate solutions in which the particles mimic the RBCs behaviour. The present work proposes a particulate-viscoelastic solution made of xanthan gum and dextran with rigid polymethylmethacrylate (PMMA) spherical particles able to mimic the effect of CFL formation that frequently happens in in vitro blood flow systems. Flow visualizations through hyperbolic contraction microchannels were used to observe the CFL originated by the proposed blood analogue fluid. Additionally, this CFL was compared with the plasma layer formed by an in vitro blood sample.application/pdfpt_PTVisualization of PMMA blood analogue fluid flowing through a hyperbolic microchannelCalejo, Joana A.C.PersonalPinho, DianaDSpacehttp://dspace.org/items/02bf2dd9-33ed-4d87-b61d-ca39c51f8451DSpacehttp://dspace.org/items/02bf2dd9-33ed-4d87-b61d-ca39c51f8451PinhoDianaCiência IDhttps://www.ciencia-id.pt5214-ED0C-35E8ORCIDhttp://orcid.org0000-0002-3884-6496PersonalGarcia, ValdemarDSpacehttp://dspace.org/items/f9422279-4412-49c2-becd-1e696a8c5c4bDSpacehttp://dspace.org/items/f9422279-4412-49c2-becd-1e696a8c5c4bGarciaValdemarORCIDhttp://orcid.org0000-0002-3941-2438Galindo-Rosales, Francisco J.PersonalLima, Rui A.DSpacehttp://dspace.org/items/7b50c499-8095-4f4f-8b1b-fa7388e4ff62DSpacehttp://dspace.org/items/7b50c499-8095-4f4f-8b1b-fa7388e4ff62LimaRui A.Ciência IDhttps://www.ciencia-id.ptEE12-C3FB-349DORCIDhttp://orcid.org0000-0003-3428-637XResearcher IDhttps://www.researcherid.comH-5157-2016Scopus Author IDhttps://www.scopus.com18437397800Campo-Deaño, LauraHostingInstitutionOrganizationalBiblioteca Digital da UPBe-mailmailto:dspace@unipb.ptdspace@unipb.ptISBNIsPartOf978-972-745-188-32018-02-20T11:43:23Z20152015-01-01T00:00:00ZHandlehttp://hdl.handle.net/10198/15830http://purl.org/coar/access_right/c_abf2open accessBlood analogue fluidPMMAHyperbolic microchannel426420 bytesFundação para a Ciência e a TecnologiaBIOMIMETIC - A biomimetic microdevice for the diagnosis of erythrocytes diseases based on their deformabilityinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FSAU-ENB%2F116929%2F2010/PTPTDC/SAU-ENB/116929/20105876-PPCDTICrossref Funder IDhttp://doi.org/10.13039/501100001871Fundação para a Ciência e a TecnologiaBlood Rheology and Red Blood Cell Migration in Microchannel Flowsinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F89077%2F2012/PTSFRH/BD/89077/2012SFRHCrossref Funder IDhttp://doi.org/10.13039/501100001871other research producthttp://purl.org/coar/resource_type/c_c94fconference object2015http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://bibliotecadigital.unipb.pt/bitstreams/bf211cd1-96c8-43b5-88ea-270ec963ff50/download6th Workshop on Green Chemistry and Nanotechnologies in Polymer Chemistry9495Bragança, Portugal |
| spellingShingle | Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel Calejo, Joana A.C. Blood analogue fluid PMMA Hyperbolic microchannel |
| status | SINGLETON |
| subject.fl_str_mv | Blood analogue fluid PMMA Hyperbolic microchannel |
| title | Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel |
| title_full | Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel |
| title_fullStr | Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel |
| title_full_unstemmed | Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel |
| title_short | Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel |
| title_sort | Visualization of PMMA blood analogue fluid flowing through a hyperbolic microchannel |
| topic | Blood analogue fluid PMMA Hyperbolic microchannel |
| topic_facet | Blood analogue fluid PMMA Hyperbolic microchannel |
| url | http://hdl.handle.net/10198/15830 |
| visible | 1 |