Publicação
Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution
| Resumo: | This paper presents the manufacturing of amicroelectrode array, on printed circuit boards (PCB) and onsilicon substrate, composed of 60 to 64 gold microelectrodes(between 4 µm and 70 µm each in diameter). The sensor has ameasurement total area of 0.5 cm in radius, one referenceelectrode (1 mm2 in area) and 28.4 mm wide and 28.4 mm long.These microelectrodes were used for checking and logging ofextracelullar local field potential of cell culture and nitritemeasurement in a phosphate buffered saline solution(electrolytical aqueous medium). In addition, an apparatus toshield from electromagnetic interference for connecting thearrays was designed to allow the capture of electrochemicalreactions or electronic signals by the microelectrodes, forexample: nitrite or cardiac potential measurement, respectively.Finally, biocompatibility tests of the array structures wereperformed. The preliminary electrical and biocompatibilitytesting, along with the collected data, has shown promisingresults pointing to the development of an accurate sensor afterthe completion of this study. The sensor has potentially abroader range of applications with only a few adaptations anddue its good accuracy it can be a very useful resource for manychemical and biological applications. |
|---|---|
| Autores principais: | Almeida, Fernando Luis de |
| Outros Autores: | Souza Junior, Wilmar; Moraes, Yann Lima; dos Santos Filho, Sebastião Gomes; Veronez, Douglas; Cestari, Idagene |
| Assunto: | Microelectronics; Electrochemical; Electronics; Bioengineering extracelullar local field potentials, myoblasts, gold microelectrodes, nitrite, heart. |
| Ano: | 2021 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | unknown |
| Instituição associada: | Instituto Superior de Engenharia de Lisboa |
| Idioma: | inglês |
| Origem: | i-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers |
| _version_ | 1868798937891078144 |
|---|---|
| author | Almeida, Fernando Luis de |
| author2 | Souza Junior, Wilmar Moraes, Yann Lima dos Santos Filho, Sebastião Gomes Veronez, Douglas Cestari, Idagene |
| author2_role | author author author author author |
| author_facet | Almeida, Fernando Luis de Souza Junior, Wilmar Moraes, Yann Lima dos Santos Filho, Sebastião Gomes Veronez, Douglas Cestari, Idagene |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Almeida, Fernando Luis de\"},{\"Person.name\":\"Souza Junior, Wilmar\"},{\"Person.name\":\"Moraes, Yann Lima\"},{\"Person.name\":\"dos Santos Filho, Sebastião Gomes\"},{\"Person.name\":\"Veronez, Douglas\"},{\"Person.name\":\"Cestari, Idagene\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Almeida, Fernando Luis de Souza Junior, Wilmar Moraes, Yann Lima dos Santos Filho, Sebastião Gomes Veronez, Douglas Cestari, Idagene |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Microelectronics; Electrochemical; Electronics; Bioengineering extracelullar local field potentials, myoblasts, gold microelectrodes, nitrite, heart. |
| datacite.titles.title.fl_str_mv | Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution |
| dc.creator.none.fl_str_mv | Almeida, Fernando Luis de Souza Junior, Wilmar Moraes, Yann Lima dos Santos Filho, Sebastião Gomes Veronez, Douglas Cestari, Idagene |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://doi.org/10.34629/ipl.isel.i-ETC.73 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | ISEL - High Institute of Engineering of Lisbon |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | i-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers; Vol 7, No 1 (2021): Vol. 7 n.1 i-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers; Vol 7, No 1 (2021): Vol. 7 n.1 2182-4010 |
| dc.subject.none.fl_str_mv | Microelectronics; Electrochemical; Electronics; Bioengineering extracelullar local field potentials, myoblasts, gold microelectrodes, nitrite, heart. |
| dc.title.fl_str_mv | Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_1843 |
| description | This paper presents the manufacturing of amicroelectrode array, on printed circuit boards (PCB) and onsilicon substrate, composed of 60 to 64 gold microelectrodes(between 4 µm and 70 µm each in diameter). The sensor has ameasurement total area of 0.5 cm in radius, one referenceelectrode (1 mm2 in area) and 28.4 mm wide and 28.4 mm long.These microelectrodes were used for checking and logging ofextracelullar local field potential of cell culture and nitritemeasurement in a phosphate buffered saline solution(electrolytical aqueous medium). In addition, an apparatus toshield from electromagnetic interference for connecting thearrays was designed to allow the capture of electrochemicalreactions or electronic signals by the microelectrodes, forexample: nitrite or cardiac potential measurement, respectively.Finally, biocompatibility tests of the array structures wereperformed. The preliminary electrical and biocompatibilitytesting, along with the collected data, has shown promisingresults pointing to the development of an accurate sensor afterthe completion of this study. The sensor has potentially abroader range of applications with only a few adaptations anddue its good accuracy it can be a very useful resource for manychemical and biological applications. |
| dirty | 0 |
| eu_rights_str_mv | unknown |
| format | article |
| id | ietc_9f6b0b9ca45eb27653784a87ec97e6ed |
| identifier.doi.fl_str_mv | https://doi.org/10.34629/ipl.isel.i-ETC.73 |
| instacron_str | isel |
| institution | Instituto Superior de Engenharia de Lisboa |
| instname_str | Instituto Superior de Engenharia de Lisboa |
| language | eng |
| network_acronym_str | ietc |
| network_name_str | i-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers |
| oai_identifier_str | oai:i-ETC.journals.isel.pt:article/73 |
| organization_str_mv | urn:organizationAcronym:isel |
| person_str_mv | Almeida, Fernando Luis de Souza Junior, Wilmar Moraes, Yann Lima dos Santos Filho, Sebastião Gomes Veronez, Douglas Cestari, Idagene |
| publishDate | 2021 |
| publisher.none.fl_str_mv | ISEL - High Institute of Engineering of Lisbon |
| reponame_str | i-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers |
| repository_id_str | urn:repositoryAcronym:ietc |
| service_str_mv | urn:repositoryAcronym:ietc |
| spelling | en-USCombined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solutionAlmeida, Fernando Luis deSouza Junior, WilmarMoraes, Yann Limados Santos Filho, Sebastião GomesVeronez, DouglasCestari, IdageneMicroelectronics; Electrochemical; Electronics; Bioengineeringextracelullar local field potentials, myoblasts, gold microelectrodes, nitrite, heart.Copyright (c) 2021 Fernando Luis de Almeida, Wilmar Souza Junior, Yann Lima Moraes, Sebastião Gomes dos Santos Filho, Douglas Veronez, Idagene Cestarihttp://purl.org/coar/access_right/c_abf2http://creativecommons.org/licenses/by-nc/4.0https://doi.org/10.34629/ipl.isel.i-ETC.73DOIoai:i-ETC.journals.isel.pt:article/73OAIhttp://journals.isel.pt/index.php/i-ETC/article/view/ID-1URLhttps://doi.org/10.34629/ipl.isel.i-ETC.73DOIhttp://journals.isel.pt/index.php/i-ETC/article/view/ID-1/73URLHasVersion2021-03-07T00:00:00Zen-USThis paper presents the manufacturing of amicroelectrode array, on printed circuit boards (PCB) and onsilicon substrate, composed of 60 to 64 gold microelectrodes(between 4 µm and 70 µm each in diameter). The sensor has ameasurement total area of 0.5 cm in radius, one referenceelectrode (1 mm2 in area) and 28.4 mm wide and 28.4 mm long.These microelectrodes were used for checking and logging ofextracelullar local field potential of cell culture and nitritemeasurement in a phosphate buffered saline solution(electrolytical aqueous medium). In addition, an apparatus toshield from electromagnetic interference for connecting thearrays was designed to allow the capture of electrochemicalreactions or electronic signals by the microelectrodes, forexample: nitrite or cardiac potential measurement, respectively.Finally, biocompatibility tests of the array structures wereperformed. The preliminary electrical and biocompatibilitytesting, along with the collected data, has shown promisingresults pointing to the development of an accurate sensor afterthe completion of this study. The sensor has potentially abroader range of applications with only a few adaptations anddue its good accuracy it can be a very useful resource for manychemical and biological applications.ISEL - High Institute of Engineering of Lisbonapplication/pdfen-USi-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers; Vol 7, No 1 (2021): Vol. 7 n.1pt-PTi-ETC : ISEL Academic Journal of Electronics Telecommunications and Computers; Vol 7, No 1 (2021): Vol. 7 n.12182-4010engjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85http://purl.org/coar/resource_type/c_1843 other research product |
| spellingShingle | Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution Almeida, Fernando Luis de Microelectronics; Electrochemical; Electronics; Bioengineering extracelullar local field potentials, myoblasts, gold microelectrodes, nitrite, heart. |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | Microelectronics; Electrochemical; Electronics; Bioengineering extracelullar local field potentials, myoblasts, gold microelectrodes, nitrite, heart. |
| title | Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution |
| title_full | Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution |
| title_fullStr | Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution |
| title_full_unstemmed | Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution |
| title_short | Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution |
| title_sort | Combined detection of nitrite and bioelectrical activity using microelectrode arrays and a phosphate buffered saline solution |
| topic | Microelectronics; Electrochemical; Electronics; Bioengineering extracelullar local field potentials, myoblasts, gold microelectrodes, nitrite, heart. |
| topic_facet | Microelectronics; Electrochemical; Electronics; Bioengineering extracelullar local field potentials, myoblasts, gold microelectrodes, nitrite, heart. |
| url | https://doi.org/10.34629/ipl.isel.i-ETC.73 |
| visible | 1 |
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