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Current Strategies to Produce 3D Electrospun-Based Wound Dressings for Skin Regeneration

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Summary:Tissue engineering-based wound dressings are a promising treatment approach that mimics the native skin microenvironment to promote effective healing and tissue regeneration. In fact, those advanced wound dressings can be made by electrospinning which has revolutionized the field of wound healing by developing biostructures that closely mimic the skin’s extracellular matrix (ECM). To date, most electrospinning research has focused on composition and materials rather than exploring advanced deposition strategies. Conventional electrospinning using random, aligned fibers, co-electrospinning, core-shell approaches, or redesigned collectors has achieved significant results in wound healing, which are discussed in this article. However, these approaches lack the development of realistic 3D structures. To achieve that, advancing approaches through the combination of electrospinning with different techniques such as gas foaming, short nanofiber assembly, or 3D printing significantly enhance skin regeneration of deep wounds (full-thickness and chronic wounds) compared to 2D structures. This review highlights the latest developments, design principles, and recent breakthroughs in electrospinning structures for skin regeneration and provides a fresh perspective for upcoming research in the field of 3D electrospun-based structures.
Main Authors:Ferreira, Carolina A. M.
Other Authors:Lemos, Marco F. L.; Maurício, Ana Colette; Dias, Juliana R.
Subject:3D structures chronic wound Electrospinning Full-Thickness wound wound healing
Year:2025
Country:Portugal
Document type:review article
Access type:open access
Associated institution:Universidade de Leiria e Oeste
Language:English
Origin:IC-online

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