Publication
Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering
| Summary: | Tissue Engineering depends on broadly techniques to regenerate tissues and/or organ functions. To do so, tailored polymeric and/or hydrogel scaffolds may be used to ensure the appropriate regeneration. Hydrogels are suitable materials for constructing cell-laden matrices as they can be produced with incorporation of cells and rapidly cross-linked in situ through photopolymerisation reactions. Measurement of the polymerization degree, as well as resistance to compression and water retention are fundamental tests to evaluate the characteristics of hydrogels. In this work, free-radical polymerisation of poly(ethylene glycol)-dimethacrylate (PEGDMA) in UV light was assessed. Several hydrogels with different photoinitiator and water contents were produced to evaluate their influence on hydrogels behaviour. Experiments showed that variations on water and photoinitiator content induce changes in the physical and chemical behaviour of hydrogels. As it was found, water content prevents polymerisation to occur and reduces the mechanical properties of hydrogels weakening them. Furthermore, differences were found in varying water content from 15 to 30%, since this increase turned hydrogels more fragile and increase their stabilization time for water retention. |
|---|---|
| Main Authors: | Lopes, João |
| Other Authors: | Fonseca, Rita; Viana, Tânia; Fernandes, Cristiana; Morouço, Pedro; Moura, Carla; Biscaia, Sara |
| Subject: | Hydrogel Photoinitiator Poly(ethylene glycol)-dimethacrylate Mechanical properties FTIR |
| Year: | 2019 |
| Country: | Portugal |
| Document type: | article |
| Access type: | open access |
| Associated institution: | Universidade de Leiria e Oeste |
| Language: | English |
| Origin: | IC-online |
| _version_ | 1877756003991158784 |
|---|---|
| author | Lopes, João |
| author2 | Fonseca, Rita Viana, Tânia Fernandes, Cristiana Morouço, Pedro Moura, Carla Biscaia, Sara |
| author2_role | author author author author author author |
| author_facet | Lopes, João Fonseca, Rita Viana, Tânia Fernandes, Cristiana Morouço, Pedro Moura, Carla Biscaia, Sara |
| author_role | author |
| contributor_name_str_mv | Repositório IC-Online |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Lopes, João\"},{\"Person.name\":\"Fonseca, Rita\",\"Person.identifier.cienciaID\":\"6E17-49F2-D317\",\"Person.identifier.orcid\":\"0000-0002-5088-8509\"},{\"Person.name\":\"Viana, Tânia\"},{\"Person.name\":\"Fernandes, Cristiana\",\"Person.identifier.cienciaID\":\"0C18-D3D1-D625\",\"Person.identifier.orcid\":\"0000-0001-6371-800X\"},{\"Person.name\":\"Morouço, Pedro\",\"Person.identifier.cienciaID\":\"F619-3996-742A\",\"Person.identifier.orcid\":\"0000-0002-5956-9790\",\"Person.identifier.researcherID\":\"K-9545-2013\",\"Person.identifier.researcherID\":\"K-9545-2013\",\"Person.identifier.scopusAuthorID\":\"24339135400\"},{\"Person.name\":\"Moura, Carla\",\"Person.identifier.cienciaID\":\"671C-8FEC-A14A\",\"Person.identifier.orcid\":\"0000-0003-2610-1005\"},{\"Person.name\":\"Biscaia, Sara\",\"Person.identifier.cienciaID\":\"0516-3C03-93F3\",\"Person.identifier.orcid\":\"0000-0002-2609-6878\",\"Person.identifier.researcherID\":\"O-1146-2013\",\"Person.identifier.scopusAuthorID\":\"55867382400\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | Repositório IC-Online |
| datacite.creators.creator.creatorName.fl_str_mv | Lopes, João Fonseca, Rita Viana, Tânia Fernandes, Cristiana Morouço, Pedro Moura, Carla Biscaia, Sara |
| datacite.date.Accepted.fl_str_mv | 2019-04-09T00:00:00Z |
| datacite.date.available.fl_str_mv | 2023-04-05T14:07:23Z |
| datacite.date.embargoed.fl_str_mv | 2023-04-05T14:07:23Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Hydrogel Photoinitiator Poly(ethylene glycol)-dimethacrylate Mechanical properties FTIR |
| datacite.titles.title.fl_str_mv | Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering |
| dc.contributor.none.fl_str_mv | Repositório IC-Online |
| dc.creator.none.fl_str_mv | Lopes, João Fonseca, Rita Viana, Tânia Fernandes, Cristiana Morouço, Pedro Moura, Carla Biscaia, Sara |
| dc.date.Accepted.fl_str_mv | 2019-04-09T00:00:00Z |
| dc.date.available.fl_str_mv | 2023-04-05T14:07:23Z |
| dc.date.embargoed.fl_str_mv | 2023-04-05T14:07:23Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.8/8334 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Trans Tech Publications |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Hydrogel Photoinitiator Poly(ethylene glycol)-dimethacrylate Mechanical properties FTIR |
| dc.title.fl_str_mv | Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Tissue Engineering depends on broadly techniques to regenerate tissues and/or organ functions. To do so, tailored polymeric and/or hydrogel scaffolds may be used to ensure the appropriate regeneration. Hydrogels are suitable materials for constructing cell-laden matrices as they can be produced with incorporation of cells and rapidly cross-linked in situ through photopolymerisation reactions. Measurement of the polymerization degree, as well as resistance to compression and water retention are fundamental tests to evaluate the characteristics of hydrogels. In this work, free-radical polymerisation of poly(ethylene glycol)-dimethacrylate (PEGDMA) in UV light was assessed. Several hydrogels with different photoinitiator and water contents were produced to evaluate their influence on hydrogels behaviour. Experiments showed that variations on water and photoinitiator content induce changes in the physical and chemical behaviour of hydrogels. As it was found, water content prevents polymerisation to occur and reduces the mechanical properties of hydrogels weakening them. Furthermore, differences were found in varying water content from 15 to 30%, since this increase turned hydrogels more fragile and increase their stabilization time for water retention. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
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| funding.funder.identifier_str_mv | http://doi.org/10.13039/501100001871 |
| funding.funder.name_str_mv | Fundação para a Ciência e a Tecnologia |
| funding.identifier_str_mv | UID/Multi/04044/2013 |
| funding.name_str_mv | 6817 - DCRRNI ID |
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| institution | Universidade de Leiria e Oeste |
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| language | eng |
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| person_str_mv | Lopes, João Fonseca, Rita Fonseca, Rita https://www.ciencia-id.pt/6E17-49F2-D317 6E17-49F2-D317 http://orcid.org/0000-0002-5088-8509 0000-0002-5088-8509 Viana, Tânia Fernandes, Cristiana Fernandes, Cristiana https://www.ciencia-id.pt/0C18-D3D1-D625 0C18-D3D1-D625 http://orcid.org/0000-0001-6371-800X 0000-0001-6371-800X Morouço, Pedro Morouço, Pedro https://www.ciencia-id.pt/F619-3996-742A F619-3996-742A http://orcid.org/0000-0002-5956-9790 0000-0002-5956-9790 Moura, Carla Moura, Carla https://www.ciencia-id.pt/671C-8FEC-A14A 671C-8FEC-A14A http://orcid.org/0000-0003-2610-1005 0000-0003-2610-1005 Biscaia, Sara Biscaia, Sara https://www.ciencia-id.pt/0516-3C03-93F3 0516-3C03-93F3 http://orcid.org/0000-0002-2609-6878 0000-0002-2609-6878 |
| publishDate | 2019 |
| publisher.none.fl_str_mv | Trans Tech Publications |
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| spelling | engTrans Tech Publicationspt_PTTissue Engineering depends on broadly techniques to regenerate tissues and/or organ functions. To do so, tailored polymeric and/or hydrogel scaffolds may be used to ensure the appropriate regeneration. Hydrogels are suitable materials for constructing cell-laden matrices as they can be produced with incorporation of cells and rapidly cross-linked in situ through photopolymerisation reactions. Measurement of the polymerization degree, as well as resistance to compression and water retention are fundamental tests to evaluate the characteristics of hydrogels. In this work, free-radical polymerisation of poly(ethylene glycol)-dimethacrylate (PEGDMA) in UV light was assessed. Several hydrogels with different photoinitiator and water contents were produced to evaluate their influence on hydrogels behaviour. Experiments showed that variations on water and photoinitiator content induce changes in the physical and chemical behaviour of hydrogels. As it was found, water content prevents polymerisation to occur and reduces the mechanical properties of hydrogels weakening them. Furthermore, differences were found in varying water content from 15 to 30%, since this increase turned hydrogels more fragile and increase their stabilization time for water retention.application/pdfpt_PTCharacterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue EngineeringLopes, JoãoPersonalFonseca, RitaDSpacehttp://dspace.org/items/6d988455-50f4-41c8-b6fc-62418d7de711DSpacehttp://dspace.org/items/6d988455-50f4-41c8-b6fc-62418d7de711FonsecaAna RitaCiência IDhttps://www.ciencia-id.pt6E17-49F2-D317ORCIDhttp://orcid.org0000-0002-5088-8509Viana, TâniaPersonalFernandes, CristianaDSpacehttp://dspace.org/items/b2b4ceb5-27a6-4c69-8726-48abb8261063DSpacehttp://dspace.org/items/b2b4ceb5-27a6-4c69-8726-48abb8261063FernandesCristiana HenriquesCiência IDhttps://www.ciencia-id.pt0C18-D3D1-D625ORCIDhttp://orcid.org0000-0001-6371-800XPersonalMorouço, PedroDSpacehttp://dspace.org/items/05b28d80-9e18-41cc-a66c-f37955bfc8daDSpacehttp://dspace.org/items/05b28d80-9e18-41cc-a66c-f37955bfc8daMorouçoPedroCiência IDhttps://www.ciencia-id.ptF619-3996-742AORCIDhttp://orcid.org0000-0002-5956-9790Researcher IDhttps://www.researcherid.comK-9545-2013Researcher IDhttps://www.researcherid.comK-9545-2013Scopus Author IDhttps://www.scopus.com24339135400PersonalMoura, CarlaDSpacehttp://dspace.org/items/33d084bb-ac8d-454a-ac58-25be1331ce04DSpacehttp://dspace.org/items/33d084bb-ac8d-454a-ac58-25be1331ce04Monteiro de MouraCarla SofiaCiência IDhttps://www.ciencia-id.pt671C-8FEC-A14AORCIDhttp://orcid.org0000-0003-2610-1005PersonalBiscaia, SaraDSpacehttp://dspace.org/items/a5f3b2b2-264b-42d3-9a94-c27e1e0cecf5DSpacehttp://dspace.org/items/a5f3b2b2-264b-42d3-9a94-c27e1e0cecf5BiscaiaSaraCiência IDhttps://www.ciencia-id.pt0516-3C03-93F3ORCIDhttp://orcid.org0000-0002-2609-6878Researcher IDhttps://www.researcherid.comO-1146-2013Scopus Author IDhttps://www.scopus.com55867382400HostingInstitutionOrganizationalRepositório IC-Onlinee-mailmailto:repositorio@ulo.ptrepositorio@ulo.ptDOIIsPartOfhttps://doi.org/10.4028/www.scientific.net/AMM.890.2902023-04-05T14:07:23Z2019-04-092019-04-09T00:00:00ZHandlehttp://hdl.handle.net/10400.8/8334http://purl.org/coar/access_right/c_abf2open accessHydrogelPhotoinitiatorPoly(ethylene glycol)-dimethacrylateMechanical propertiesFTIR1931929 bytesFundação para a Ciência e a TecnologiaCentre for Rapid and Sustainable Product Developmentinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2013/PTUID/Multi/04044/20136817 - DCRRNI IDCrossref Funder IDhttp://doi.org/10.13039/501100001871literaturehttp://purl.org/coar/resource_type/c_6501journal article2019-04-09http://creativecommons.org/licenses/by/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://iconline.ulo.pt/bitstreams/cfdbdb92-80d1-459d-a4d8-b08aa7e9e312/downloadApplied Mechanics and Materials890290300 |
| spellingShingle | Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering Lopes, João Hydrogel Photoinitiator Poly(ethylene glycol)-dimethacrylate Mechanical properties FTIR |
| status | SINGLETON |
| subject.fl_str_mv | Hydrogel Photoinitiator Poly(ethylene glycol)-dimethacrylate Mechanical properties FTIR |
| title | Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering |
| title_full | Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering |
| title_fullStr | Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering |
| title_full_unstemmed | Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering |
| title_short | Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering |
| title_sort | Characterization of Biocompatible Poly(Ethylene Glycol)-Dimethacrylate Hydrogels for Tissue Engineering |
| topic | Hydrogel Photoinitiator Poly(ethylene glycol)-dimethacrylate Mechanical properties FTIR |
| topic_facet | Hydrogel Photoinitiator Poly(ethylene glycol)-dimethacrylate Mechanical properties FTIR |
| url | http://hdl.handle.net/10400.8/8334 |
| visible | 1 |