Publicação
Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury
| Resumo: | Dendrimers and dendriplexes, highly branched synthetic macromolecules, have gained popularity as new tools for a variety of nanomedicine strategies due to their unique structure and properties. We show that fluorescent phosphorus dendrimers are well retained by bone marrow-derived macrophages and exhibit robust spectral shift in its emission in response to polar ization conditions. Fluorescence properties of this marker can also assist in identifying macrophage presence and phenotype status at different time points after spinal cord injury. Potential use of a single dendrimer compound as a drug/siRNA carrier and phenotype-specific cell tracer offers new avenues for enhanced cell therapies combined with monitor ing of cell fate and function in spinal cord injury. |
|---|---|
| Autores principais: | Shakhbazau, Antos |
| Outros Autores: | Mishra, Manoj; Chu, Tak‐Ho; Brideau, Craig; Cummins, Karen; Tsutsui, Shigeki; Shcharbin, Dzmitry; Majoral, Jean‐Pierre; Mignani, Serge; Blanchard‐Desce, Mireille; Bryszewska, Maria; Yong, V. Wee; Stys, Peter K.; van Minnen, Jan |
| Assunto: | Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Tipo de acesso: | acesso aberto |
| Instituição associada: | Universidade da Madeira |
| Idioma: | inglês |
| Origem: | DigitUMa - Repositório da Universidade da Madeira |
| _version_ | 1877781960319827968 |
|---|---|
| author | Shakhbazau, Antos |
| author2 | Mishra, Manoj Chu, Tak‐Ho Brideau, Craig Cummins, Karen Tsutsui, Shigeki Shcharbin, Dzmitry Majoral, Jean‐Pierre Mignani, Serge Blanchard‐Desce, Mireille Bryszewska, Maria Yong, V. Wee Stys, Peter K. van Minnen, Jan |
| author2_role | author author author author author author author author author author author author author |
| author_facet | Shakhbazau, Antos Mishra, Manoj Chu, Tak‐Ho Brideau, Craig Cummins, Karen Tsutsui, Shigeki Shcharbin, Dzmitry Majoral, Jean‐Pierre Mignani, Serge Blanchard‐Desce, Mireille Bryszewska, Maria Yong, V. Wee Stys, Peter K. van Minnen, Jan |
| author_role | author |
| contributor_name_str_mv | DigitUMa |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Shakhbazau, Antos\"},{\"Person.name\":\"Mishra, Manoj\"},{\"Person.name\":\"Chu, Tak‐Ho\"},{\"Person.name\":\"Brideau, Craig\"},{\"Person.name\":\"Cummins, Karen\"},{\"Person.name\":\"Tsutsui, Shigeki\"},{\"Person.name\":\"Shcharbin, Dzmitry\"},{\"Person.name\":\"Majoral, Jean‐Pierre\"},{\"Person.name\":\"Mignani, Serge\",\"Person.identifier.cienciaID\":\"8018-B5D2-6983\",\"Person.identifier.orcid\":\"0000-0002-1383-5256\",\"Person.identifier.scopusAuthorID\":\"7003374430\"},{\"Person.name\":\"Blanchard‐Desce, Mireille\"},{\"Person.name\":\"Bryszewska, Maria\"},{\"Person.name\":\"Yong, V. Wee\"},{\"Person.name\":\"Stys, Peter K.\"},{\"Person.name\":\"van Minnen, Jan\"}] |
| datacite.contributors.contributor.contributorName.fl_str_mv | DigitUMa |
| datacite.creators.creator.creatorName.fl_str_mv | Shakhbazau, Antos Mishra, Manoj Chu, Tak‐Ho Brideau, Craig Cummins, Karen Tsutsui, Shigeki Shcharbin, Dzmitry Majoral, Jean‐Pierre Mignani, Serge Blanchard‐Desce, Mireille Bryszewska, Maria Yong, V. Wee Stys, Peter K. van Minnen, Jan |
| datacite.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| datacite.date.available.fl_str_mv | 2024-02-28T14:32:10Z |
| datacite.date.embargoed.fl_str_mv | 2024-02-28T14:32:10Z |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia |
| datacite.titles.title.fl_str_mv | Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury |
| dc.contributor.none.fl_str_mv | DigitUMa |
| dc.creator.none.fl_str_mv | Shakhbazau, Antos Mishra, Manoj Chu, Tak‐Ho Brideau, Craig Cummins, Karen Tsutsui, Shigeki Shcharbin, Dzmitry Majoral, Jean‐Pierre Mignani, Serge Blanchard‐Desce, Mireille Bryszewska, Maria Yong, V. Wee Stys, Peter K. van Minnen, Jan |
| dc.date.Accepted.fl_str_mv | 2015-01-01T00:00:00Z |
| dc.date.available.fl_str_mv | 2024-02-28T14:32:10Z |
| dc.date.embargoed.fl_str_mv | 2024-02-28T14:32:10Z |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | http://hdl.handle.net/10400.13/5588 |
| dc.language.none.fl_str_mv | eng |
| dc.publisher.none.fl_str_mv | Wiley |
| dc.rights.cclincense.fl_str_mv | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.subject.none.fl_str_mv | Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia |
| dc.title.fl_str_mv | Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 |
| description | Dendrimers and dendriplexes, highly branched synthetic macromolecules, have gained popularity as new tools for a variety of nanomedicine strategies due to their unique structure and properties. We show that fluorescent phosphorus dendrimers are well retained by bone marrow-derived macrophages and exhibit robust spectral shift in its emission in response to polar ization conditions. Fluorescence properties of this marker can also assist in identifying macrophage presence and phenotype status at different time points after spinal cord injury. Potential use of a single dendrimer compound as a drug/siRNA carrier and phenotype-specific cell tracer offers new avenues for enhanced cell therapies combined with monitor ing of cell fate and function in spinal cord injury. |
| dirty | 0 |
| eu_rights_str_mv | openAccess |
| format | article |
| fulltext.url.fl_str_mv | https://digituma.uma.pt/bitstreams/608ceafe-ae60-452e-80cb-183378f5aea0/download |
| id | digituma_7f415e366f458bd762aaf8d27e8a2bee |
| identifier.url.fl_str_mv | http://hdl.handle.net/10400.13/5588 |
| inst_facet_str | urn:organizationAcronym:digituma{{{_:::_}}}Universidade da Madeira |
| instacron_str | digituma |
| institution | Universidade da Madeira |
| instname_str | Universidade da Madeira |
| language | eng |
| network_acronym_str | digituma |
| network_name_str | DigitUMa - Repositório da Universidade da Madeira |
| oai_identifier_str | oai:digituma.uma.pt:10400.13/5588 |
| organization_str_mv | urn:organizationAcronym:digituma |
| person_str_mv | Shakhbazau, Antos Mishra, Manoj Chu, Tak‐Ho Brideau, Craig Cummins, Karen Tsutsui, Shigeki Shcharbin, Dzmitry Majoral, Jean‐Pierre Mignani, Serge Mignani, Serge https://www.ciencia-id.pt/8018-B5D2-6983 8018-B5D2-6983 http://orcid.org/0000-0002-1383-5256 0000-0002-1383-5256 Blanchard‐Desce, Mireille Bryszewska, Maria Yong, V. Wee Stys, Peter K. van Minnen, Jan |
| publishDate | 2015 |
| publisher.none.fl_str_mv | Wiley |
| repo_facet_str | urn:repositoryAcronym:digituma{{{_:::_}}}DigitUMa - Repositório da Universidade da Madeira |
| reponame_str | DigitUMa - Repositório da Universidade da Madeira |
| repository_id_str | urn:repositoryAcronym:digituma |
| service_str_mv | urn:repositoryAcronym:digituma |
| spelling | engWileypt_PTDendrimers and dendriplexes, highly branched synthetic macromolecules, have gained popularity as new tools for a variety of nanomedicine strategies due to their unique structure and properties. We show that fluorescent phosphorus dendrimers are well retained by bone marrow-derived macrophages and exhibit robust spectral shift in its emission in response to polar ization conditions. Fluorescence properties of this marker can also assist in identifying macrophage presence and phenotype status at different time points after spinal cord injury. Potential use of a single dendrimer compound as a drug/siRNA carrier and phenotype-specific cell tracer offers new avenues for enhanced cell therapies combined with monitor ing of cell fate and function in spinal cord injury.application/pdfpt_PTFluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injuryShakhbazau, AntosMishra, ManojChu, Tak‐HoBrideau, CraigCummins, KarenTsutsui, ShigekiShcharbin, DzmitryMajoral, Jean‐PierrePersonalMignani, SergeDSpacehttp://dspace.org/items/cabd0aa0-5827-4e97-889b-922136d2dd4bDSpacehttp://dspace.org/items/cabd0aa0-5827-4e97-889b-922136d2dd4bMignaniSergeCiência IDhttps://www.ciencia-id.pt8018-B5D2-6983ORCIDhttp://orcid.org0000-0002-1383-5256Scopus Author IDhttps://www.scopus.com7003374430Blanchard‐Desce, MireilleBryszewska, MariaYong, V. WeeStys, Peter K.van Minnen, JanHostingInstitutionOrganizationalDigitUMae-mailmailto:digituma@uma.ptdigituma@uma.ptDOIIsPartOf10.1002/mabi.2015001502024-02-28T14:32:10Z20152015-01-01T00:00:00ZHandlehttp://hdl.handle.net/10400.13/5588http://purl.org/coar/access_right/c_abf2open accessMacrophage polarizationSpinal cord injuryFluorescent phosphorus dendrimerCell trackerSpectral.Faculdade de Ciências Exatas e da Engenharia1712652 bytesliteraturehttp://purl.org/coar/resource_type/c_6501journal article2015http://creativecommons.org/licenses/by-nc-nd/4.0/http://purl.org/coar/access_right/c_abf2application/pdffulltexthttps://digituma.uma.pt/bitstreams/608ceafe-ae60-452e-80cb-183378f5aea0/downloadMacromolecular Bioscience151115231534 |
| spellingShingle | Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury Shakhbazau, Antos Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia |
| status | SINGLETON |
| subject.fl_str_mv | Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia |
| title | Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury |
| title_full | Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury |
| title_fullStr | Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury |
| title_full_unstemmed | Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury |
| title_short | Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury |
| title_sort | Fluorescent phosphorus dendrimer as a spectral nanosensor for macrophage polarization and fate tracking in spinal cord injury |
| topic | Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia |
| topic_facet | Macrophage polarization Spinal cord injury Fluorescent phosphorus dendrimer Cell tracker Spectral . Faculdade de Ciências Exatas e da Engenharia |
| url | http://hdl.handle.net/10400.13/5588 |
| visible | 1 |
Atividades financiadas
Não foram encontrados projetos financiados.