Publicação

An experimental test on the probability of extinction of new genetic variants

Ver documento

Detalhes bibliográficos
Resumo:In 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost with high probability. Here we demonstrate that extinction rates decrease with increasing initial numbers of beneficial alleles, as expected, by performing invasion experiments with inbred lines of the nematode Caenorhabditis elegans. We further show that the extinction rates of deleterious alleles are higher than those of beneficial alleles, also as expected. Interestingly, we also find that for these inbred lines, when at intermediate frequencies, the fate of invaders might not result in their ultimate fixation or loss but on their maintenance. Our study confirms the key results from classical population genetics and highlights that the nature of adaptation can be complex.
Autores principais:Chelo, Ivo M.
Outros Autores:Nédli, Judit; Gordo, Isabel; Teotónio, Henrique
Assunto:Extinction, Biological Genetic Variation Probability
Ano:2013
País:Portugal
Tipo de documento:artigo
Tipo de acesso:acesso aberto
Instituição associada:Repositório do GIMM – Gulbenkian Institute for Molecular Medicine
Idioma:inglês
Origem:ARCA

Registos relacionados

Atividades financiadas

Carregando projetos financiados...

Ver mais

Registos relacionados