Publicação
Endocytosis and intracellular trafficking of nanomaterials
| Resumo: | Recent advances in nanotechnology have increased the use of nanomaterials and nanodevices for diagnostic, therapeutic and other technological applications. The knowledge about the interaction between nanomaterials and biological media allows the development of more rational applications, as well understand and anticipate adverse and toxic effects resulting from this interaction. Endocytosis is an energy-dependent biological process responsible for internalization of nanoparticles, which depends on orchestrated events that require lipids and plasma membrane proteins functioning. Studies that aim to investigate in detail the endocytosis and intracellular trafficking of nanoparticles are essential for understanding cellular mechanisms, which in turn help to select its biomedical applications. In this context, this review aims to conceptualize the main routes of endocytosis used to study the internalization of nanomaterials in eukaryotic cells. In addition, we discuss some intracellular trafficking of nanomaterials to aid in studies of the cellular processing and development of new therapeutic tools. |
|---|---|
| Autores principais: | Ferreira, L. A. B. |
| Outros Autores: | Radaic, A.; Pugliese, G. O.; Valentini, M. B.; Oliveira, M. R.; de Jesus, M. B. |
| Assunto: | endocytosis nanoparticle intracellular trafficking Endocitose nanopartícula tráfego intracelular |
| Ano: | 2015 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Instituição associada: | Ordem dos Farmacêuticos do Porto |
| Idioma: | português |
| Origem: | Acta Farmacêutica Portuguesa |
| _version_ | 1877792667557953536 |
|---|---|
| author | Ferreira, L. A. B. |
| author2 | Radaic, A. Pugliese, G. O. Valentini, M. B. Oliveira, M. R. de Jesus, M. B. |
| author2_role | author author author author author |
| author_facet | Ferreira, L. A. B. Radaic, A. Pugliese, G. O. Valentini, M. B. Oliveira, M. R. de Jesus, M. B. |
| author_role | author |
| country_str | PT |
| creators_json_txt | [{\"Person.name\":\"Ferreira, L. A. B.\"},{\"Person.name\":\"Radaic, A.\"},{\"Person.name\":\"Pugliese, G. O.\"},{\"Person.name\":\"Valentini, M. B.\"},{\"Person.name\":\"Oliveira, M. R.\"},{\"Person.name\":\"de Jesus, M. B.\"}] |
| datacite.creators.creator.creatorName.fl_str_mv | Ferreira, L. A. B. Radaic, A. Pugliese, G. O. Valentini, M. B. Oliveira, M. R. de Jesus, M. B. |
| datacite.rights.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| datacite.subjects.subject.fl_str_mv | endocytosis nanoparticle intracellular trafficking Endocitose nanopartícula tráfego intracelular |
| datacite.titles.title.fl_str_mv | Endocytosis and intracellular trafficking of nanomaterials Endocitose e tráfego intracelular de nanomateriais |
| dc.creator.none.fl_str_mv | Ferreira, L. A. B. Radaic, A. Pugliese, G. O. Valentini, M. B. Oliveira, M. R. de Jesus, M. B. |
| dc.description.none.fl_str_mv | Os avanços recentes da nanotecnologia têm aumentado a utilização de nanomateriais e nanodispositivos para diagnose, terapias e outros fins tecnológicos. O conhecimento da interação entre nanomateriais e meios biológicos permite a descoberta de aplicações mais racionais, podendo ajudar a entender e antever seus efeitos adversos e citotóxicos. A endocitose é um processo biológico dependente de energia que está envolvida na internalização de nanopartículas pelas células, e depende de eventos orquestrados que requerem o funcionamento coordenado dos lipídios e proteínas da membrana plasmática. Estudos que visam investigar em detalhes a endocitose e o tráfego intracelular de nanopartículas são indispensáveis para compreensão de mecanismos celulares ainda inexplorados e permitem projetar novas funções, que consequentemente auxiliam na escolha de aplicações biomédicas da nanotecnologia. Nesse contexto, esta revisão visa conceituar as principais vias de endocitose utilizadas no estudo da internalização de nanomateriais em células eucarióticas. Além disso, alguns destinos intracelulares de nanomateriais serão discutidos para auxiliar nos estudos do processamento celular de nanopartículas e desenvolvimento de novas ferramentas terapêuticas. |
| dc.format.none.fl_str_mv | application/pdf |
| dc.identifier.none.fl_str_mv | https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54 |
| dc.language.none.fl_str_mv | por |
| dc.publisher.none.fl_str_mv | Acta Farmacêutica Portuguesa |
| dc.rights.none.fl_str_mv | http://purl.org/coar/access_right/c_abf2 |
| dc.source.none.fl_str_mv | Acta Farmacêutica Portuguesa; v. 3 n. 2 (2014); 149-166 2182-3340 |
| dc.subject.none.fl_str_mv | endocytosis nanoparticle intracellular trafficking Endocitose nanopartícula tráfego intracelular |
| dc.title.fl_str_mv | Endocytosis and intracellular trafficking of nanomaterials Endocitose e tráfego intracelular de nanomateriais |
| dc.type.none.fl_str_mv | http://purl.org/coar/resource_type/c_6501 http://purl.org/coar/resource_type/c_6501 |
| description | Recent advances in nanotechnology have increased the use of nanomaterials and nanodevices for diagnostic, therapeutic and other technological applications. The knowledge about the interaction between nanomaterials and biological media allows the development of more rational applications, as well understand and anticipate adverse and toxic effects resulting from this interaction. Endocytosis is an energy-dependent biological process responsible for internalization of nanoparticles, which depends on orchestrated events that require lipids and plasma membrane proteins functioning. Studies that aim to investigate in detail the endocytosis and intracellular trafficking of nanoparticles are essential for understanding cellular mechanisms, which in turn help to select its biomedical applications. In this context, this review aims to conceptualize the main routes of endocytosis used to study the internalization of nanomaterials in eukaryotic cells. In addition, we discuss some intracellular trafficking of nanomaterials to aid in studies of the cellular processing and development of new therapeutic tools. |
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| person_str_mv | Ferreira, L. A. B. Radaic, A. Pugliese, G. O. Valentini, M. B. Oliveira, M. R. de Jesus, M. B. |
| publishDate | 2015 |
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| spelling | en-USEndocytosis and intracellular trafficking of nanomaterialspt-PTEndocitose e tráfego intracelular de nanomateriaisFerreira, L. A. B.Radaic, A.Pugliese, G. O.Valentini, M. B.Oliveira, M. R.de Jesus, M. B.endocytosis nanoparticleintracellular traffickingEndocitosenanopartículatráfego intracelularhttps://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54URLoai:ojs.actafarmaceuticaportuguesa.com:article/54OAIhttps://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54URLhttps://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54/89URLHasVersion2015-03-01T00:00:00Zhttp://purl.org/coar/access_right/c_abf2en-USRecent advances in nanotechnology have increased the use of nanomaterials and nanodevices for diagnostic, therapeutic and other technological applications. The knowledge about the interaction between nanomaterials and biological media allows the development of more rational applications, as well understand and anticipate adverse and toxic effects resulting from this interaction. Endocytosis is an energy-dependent biological process responsible for internalization of nanoparticles, which depends on orchestrated events that require lipids and plasma membrane proteins functioning. Studies that aim to investigate in detail the endocytosis and intracellular trafficking of nanoparticles are essential for understanding cellular mechanisms, which in turn help to select its biomedical applications. In this context, this review aims to conceptualize the main routes of endocytosis used to study the internalization of nanomaterials in eukaryotic cells. In addition, we discuss some intracellular trafficking of nanomaterials to aid in studies of the cellular processing and development of new therapeutic tools.pt-PTOs avanços recentes da nanotecnologia têm aumentado a utilização de nanomateriais e nanodispositivos para diagnose, terapias e outros fins tecnológicos. O conhecimento da interação entre nanomateriais e meios biológicos permite a descoberta de aplicações mais racionais, podendo ajudar a entender e antever seus efeitos adversos e citotóxicos. A endocitose é um processo biológico dependente de energia que está envolvida na internalização de nanopartículas pelas células, e depende de eventos orquestrados que requerem o funcionamento coordenado dos lipídios e proteínas da membrana plasmática. Estudos que visam investigar em detalhes a endocitose e o tráfego intracelular de nanopartículas são indispensáveis para compreensão de mecanismos celulares ainda inexplorados e permitem projetar novas funções, que consequentemente auxiliam na escolha de aplicações biomédicas da nanotecnologia. Nesse contexto, esta revisão visa conceituar as principais vias de endocitose utilizadas no estudo da internalização de nanomateriais em células eucarióticas. Além disso, alguns destinos intracelulares de nanomateriais serão discutidos para auxiliar nos estudos do processamento celular de nanopartículas e desenvolvimento de novas ferramentas terapêuticas.Acta Farmacêutica Portuguesaapplication/pdfpt-PTActa Farmacêutica Portuguesa; v. 3 n. 2 (2014); 149-1662182-3340porjournal articlehttp://purl.org/coar/resource_type/c_6501literatureVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85journal articlehttp://purl.org/coar/resource_type/c_6501literature |
| spellingShingle | Endocytosis and intracellular trafficking of nanomaterials Ferreira, L. A. B. endocytosis nanoparticle intracellular trafficking Endocitose nanopartícula tráfego intracelular |
| status | SINGLETON |
| status_str | VoR |
| subject.fl_str_mv | endocytosis nanoparticle intracellular trafficking Endocitose nanopartícula tráfego intracelular |
| title | Endocytosis and intracellular trafficking of nanomaterials |
| title_full | Endocytosis and intracellular trafficking of nanomaterials |
| title_fullStr | Endocytosis and intracellular trafficking of nanomaterials |
| title_full_unstemmed | Endocytosis and intracellular trafficking of nanomaterials |
| title_short | Endocytosis and intracellular trafficking of nanomaterials |
| title_sort | Endocytosis and intracellular trafficking of nanomaterials |
| topic | endocytosis nanoparticle intracellular trafficking Endocitose nanopartícula tráfego intracelular |
| topic_facet | endocytosis nanoparticle intracellular trafficking Endocitose nanopartícula tráfego intracelular |
| url | https://actafarmaceuticaportuguesa.com/index.php/afp/article/view/54 |
| visible | 1 |
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