Publicação
Estado da arte na terapêutica anticoagulante: Novas abordagens
| Resumo: | Anticoagulant therapy was for a long time, limited to the use of heparins and warfarins. Recently, has been introduced in the market new alternative antithrombotic to this therapy. The availability of an oral of FXa or thrombin inhibitors has provided relevant clinical results in assays for the prophylaxis of postoperative venous thrombosis. However, these drugs do not have the polypharmacology of heparins. In this context, the investigation of small molecules that mimic the functions of the sulfated glycosaminoglycans, without the drawbacks characteristic of large chain heparins, has emerged as an area of research alternative. In this work, the major therapeutic approaches for the treatment of venous thrombosis are exposed, and is given a special focus to the study of our research group in the search for small molecules active dual antiplatelet and anticoagulant. Keywords: Anticoagulant therapy, Warfarins, Sulfated glycosaminoglycans |
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| Autores principais: | Correia-da-Silva, M. |
| Outros Autores: | Sousa, E.; Marques, Franklim; Pinto, M.M. |
| Assunto: | Terapêutica anticoagulante Varfarina Glicoaminoglicanos sulfatados |
| Ano: | 2013 |
| País: | Portugal |
| Tipo de documento: | artigo |
| Instituição associada: | Ordem dos Farmacêuticos do Porto |
| Idioma: | português |
| Origem: | Acta Farmacêutica Portuguesa |
| Resumo: | Anticoagulant therapy was for a long time, limited to the use of heparins and warfarins. Recently, has been introduced in the market new alternative antithrombotic to this therapy. The availability of an oral of FXa or thrombin inhibitors has provided relevant clinical results in assays for the prophylaxis of postoperative venous thrombosis. However, these drugs do not have the polypharmacology of heparins. In this context, the investigation of small molecules that mimic the functions of the sulfated glycosaminoglycans, without the drawbacks characteristic of large chain heparins, has emerged as an area of research alternative. In this work, the major therapeutic approaches for the treatment of venous thrombosis are exposed, and is given a special focus to the study of our research group in the search for small molecules active dual antiplatelet and anticoagulant. Keywords: Anticoagulant therapy, Warfarins, Sulfated glycosaminoglycans |
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