Objective: The 3E (Evidence, Expertise, Exchange) Initiative is a multinational effort of rheumatologists aimed at developing evidence-based recommendations addressing specific questions relevant to clinical practice. The objective of the Portuguese contribution for the 3E Initiative was to develop evidence-based recommendations on how to investigate, follow-up and treat undifferentiated peripheral inflammatory arthritis (UPIA) adapted to local reality and develop additional recommendations considered relevant in the national context. Methods: An international scientific committee from 17 countries selected a set of questions concerning the diagnosis and monitoring of UPIA using a Delphi procedure. Evidence-based answers to each question were sought by a systematic literature search, performed in Medline, Embase, the Cochrane Library and ACR/EULAR 2007-2009 meeting abstracts. Relevant articles were reviewed for quality assessment, data extraction and synthesis. In a national meeting, a panel of 63 Portuguese rheumatologists used the evidence which was gathered to develop recommendations, and filled the gaps in the evidence with their expert opinion. Finally, national recommendations were formulated and agreement among the participants was assessed. Results: A total of 54754 references were identified, of which 267 were systematically reviewed. Thirteen national key recommendations about the investigation, follow-up and treatment of UPIA were formulated. One recommendation addressed differential diagnosis and investigations prior to the established operational diagnosis of UPIA, eight recommendations were related to the diagnostic and prognostic value of clinical and laboratory assessments in established UPIA (history and physical examination, acute phase reactants, serologies, autoantibodies, radiographs, magnetic resonance imaging and ultrasound, genetic markers and synovial biopsy), one recommendation highlighted predictors of persistence (chronicity), one addressed monitoring of clinical disease activity in UPIA, one aimed to find an useful method/score to predict a definitive diagnosis and the last one was related to treatment. Conclusion: Portuguese evidence-based recommendations for the management of UPIA in everyday practice were developed. Their dissemination and implementation in daily clinical practice should help to improve practice uniformity and optimize the management of UPIA patients.

A Revista Brasileira de Medicina de Família e Comunidade (RBMFC) agradece aos membros de seu Corpo Editorial abaixo listados, pelas horas dedicadas voluntariamente para avaliação dos trabalhos submetidos à publicação e pelas demais contribuições para a melhoria da qualidade científica de nosso periódico.Adilson Domingos dos Reis Filho - UNICAdriana Valéria Assunção Ramos - UNIFORAirton Tetelbom Stein - UFCSPAAlberto Novaes Ramos Jr - UFCAldaísa Cassanho Forster - UNIVALIAlessandro da Silva Scholze - UNIVALIAlessandro Leite Cavalcanti - UFPBAlexsandro Nascimento Costa - UESBAline Guerra Aquilante - UFSCarAltacílio Aparecido Nunes - USPAmaury Lelis Dal-Fabbro - USPAna Cristina Vidor - PFMAna Maria Galdini Raimundo Oda - UFSCarAna Maria Garcia Andrade - PMPAAna Regina Noto Faria - UNIFESPAnderson Soares Silva - USPAndré  Messias - USPAndré Luís Andrade Justino - SMSDCAndré Luís Bezerra Tavares - UFCAndré Silvia Walter de Aguiar - UFCAngela Helena Marin - UNISINOSAngélica  Manfroi - SBMFCAngelmar Constantino Roman - UPArmando Henrique Norman - SBMFCAugustus Tadeu Relo de Mattos - UFCBruno José Barcellos Fontanella - UFSCarBruno Souza Benevides - UECECamila Giugliani - UFRGSCarla Maria Ramos Germano - UFSCarCarlo Roberto Hackmann da Cunha - PMFCarlos Alexandre Rodrigues Pereira - CEUCarlos Eduardo Aguilera Campos - UFRJCássio  Silveira - UNIFESPCélia Regina Machado Saldanha - FCMS/JFCelso Zilbovicius - UNIFESPCésar Augusto O Favoreto - UERJCésar Monte Serrat Titton - PMCCharles Dalcanale Tesser - UFSCCristina Rolim Neumann - UFRGSCristine Vieira do Bonfim - FUNDAJDaniel Almeida Gonçalves - UNIFESPDaniel Knupp Augusto - SMSA/BHDaniela  Dallegrave - GHCDannielle Fernandes Godoi - UFSCDavid Matos Milhomens - SBMFCDébora Gusmão Melo - UFSCarDébora Modesto Barbosa - UNIFRANEdson Iglesias Vidal - HAEElisa Harumi Kozasa - UNIFESPElson Romeu Farias - ULBRAEno Dias de Castro Filho - UFRGSErnani Tiaraju de Santa Helena - FURBErno Harzheim - UFRGSFelipe Sparrenberger - FURBFernanda Lazzari Freitas - PMFFernando Soares Guedes - CENTAPFrancisco Jorge Arsego Quadros de Oliveira - UFRGSFúlvio Borges Nedel - UNISCGabriela dos Santos Buccini - HSMGary Saavedra - SBMFCGeovani Gurgel Aciole da Silva - UFSCarGiannina do Espírito-Santo - UNISUAMGuilherme Arantes Mello - UNIFESPGuilherme Coelho Dantas - PUCRSGustavo de Araújo Porto Landsberg - UNIFENASGustavo Diniz Ferreira Gusso - USPGustavo Salata Romão - UFSCarHamilton Lima Wagner - SBMFCIsanete Geraldini Costa Bieski - UFMTJoão Mazzoncini de Azevedo Marques - USPJoão Rodolfo Hopp - FUNDACENTROJoão Werner Falk - UFRGSJosane Aparecida Araujo Norman - SBMFCJosé Aroldo Lima Gonçalves-Filho - PMERJJosé Carlos Prado Junior - SMSDCJosé Eduardo Corrente - UNESPJosé Eduardo de Paula Lima - UFSCarJosé Mauro C Lopes - GHCJose Ricardo  de Mello Brandão - USPJosenaide Engracia Santos - UNEBJosiana Kely Moreira - UEPAJuan Gérvas - Equipo CESCA - Madrid, EspanhaJuliana Oliveira Soares - SMS/DFJuliana Santos - SBMFCJuliany Luz - PMBKatsumi Osiro - UNIFESPLeonardo Araújo de Souza - FIOCRUZLeonardo Cançado Monteiro Savassi - UFOPLeonardo Ierardi Goulart - UFOPLeonardo Vieira Targa - UCSLilian Fatima Barbosa Marinho - FUNASALiz Ponnet - UNIFESPLucas Mello Pioner - UFSCLucia Alves S Lara - USPLuciana Kind - PUCMGLuciane Loures dos Santos - USPLucimare  Ferraz - UDESCLuís Antônio Benvegnú - UNIJUILuis Antonio Ribeiro - UNIVAPLuís Filipe Cavadas - Unidade Local de Saúde de Matosinhos, Portugal, PortugalLuis Pisco - PortugalLuiz Carlos de Abreu - USPLuiz Felipe Cunha Mattos - GHCLuiz Miguel Santiago - Universidade da Beira Interior, PortugalMagda Moura de Almeida Porto - UNIFORMarcello Dala Bernardina Dalla - UVVMarcelo Kolling - UFRGSMarcelo Marcos Piva Demarzo - UNIFESPMarcelo Rodrigues Gonçalves - UFCSPAMárcia Lúcia da Silva Fagundes Marques - FMABCMárcia Regina Martins Alvarenga - UEMSMarcio Costa de Souza - UESBMarco Aurélio Oliveira Góes - UFSMarco Túlio Aguiar Mourão Ribeiro - UFCMarcos Augusto Sciascia Magalhães Bressan - SBMFCMaria Amália de Campos Oliveira - USPMaria Catarina Salvador Motta - UFRJMaria Célia Mendes - USPMaria Cristiane Barbosa Galvão - USPMaria Eugênia Bresolin Pinto - UFCSPAMaria Inês Reinert Azambuja - UFRGSMaria Inez Padula Anderson - UERJMaria Lucélia da Hora Sales - UNCISALMario Maia Bracco - UFSCarMaristela Carbol - UFSCarMarlos Suenney de Mendonça Noronha - UFSMoema Guimarães Motta - UFFMyriam Carneiro de França - UNIPENathan Mendes Souza - McMaster University, CanadáNelson Robson Mendes de Souza - UERJNicanor Rodrigues da Silva Pinto - UNIFESPNilson Massakazu Ando - SEMSANúlvio  Lermen Júnior - SMSRJOlga Maria Fernandes de Carvalho - UNICAMPPablo de Lannoy Stürmer - GHCPaola Colares de Borba - UNIFORPatricia Barreto Cavalcanti - UFPBPatricia Sampaio Chueiri - MSPatricia Taira Nakanishi - UNBPaulo Poli Neto - PMFPaulo Schor - UNIFESPPetterson de Jesus Floriano - UFSCARRachel de Faria Brino - UFSCarRaquel Miguel Rodrigues - ICECENSARenan Magalhães Montenegro Junior - UFCRenata Cereda Cordeiro - UNIFESPRenata Giannecchini Bongiovanni Kishi - UFSCarRenê Werton Veras - HCVRicardo Alexandre de Souza - SBMFCRicardo Carlos Cordeiro - UNICAMPRicardo de Mattos Russo Rafael - UNIGRicardo Donato Rodrigues - UERJRoberta Alvarenga Reis - UFRGSRoberto Nunes Umpierre - GHCRodolfo de Carvalho Pacagnella - UFSCarRodrigo Caprio Leite de Castro - UFRGSRodrigo da Silva Dias - UEPARogerio Luz Coelho Neto - FEPARRosana Pimentel Correia Moysés - UFAMRosana Viana Frazili - FATEARosangela Ziggiotti Oliveira - UEMRuth Borges Dias - UNIFENASSampaio Santana - SBMFCSandra Aparecida Ribeiro - UNIFESPSandra Fortes - UERJSandro Rogerio Rodrigues Batista - UFGSergio Antonio Sirena - GHCSérgio Eduardo de Andrade Perez - UFSCarShamyr Sulyvan de Castro - UFTMSofia Mendonca - UNIFESPTânia Araujo Barboza - UNIFORTania Toledo Oliverai - UFVThiago Dias Sarti - UFESThiago Gomes da Trindade - UFRNThiago Roberto Castellane Arena - USPTiago Villanueva Gutierrez Marques - SBMFCUbiratan  Adler - UFSCarValéria Ferreira Romano - UFRJVitor Engrácia Valenti - UNESP/MaríliaWilma Madeira - USPYuji Magalhães Ikuta - UEPAZeliete Linhares Leite Zambon - SBMFC 

The Oporto School of Law of the Catholic University of Portugal awards dozens of students each year with a Master's degree in Law, in seven areas of specialization, as well as a Master's degree in Law and Management. In order to give visibility to the result of the research, the Oporto School of Law School has taken the decision to publish the master's dissertations that have obtained the highest grades.Thus, from 2019 and henceforth, the best master's dissertations, whose exams took place by December 8 of the previous calendar year, will be published each year. This disclosure allows quality research to be shared with the rest of the scientific community. In addition, it is an incentive for the qualification of the research of Master's students in Law and in Law and Management.It is our conviction that this initiative contributes to a useful sharing of knowledge and allows for the opening of a dialogue with the legal community and civil society.This issue includes thirty-eight dissertations. They are presented in alphabetical order and cover areas as diverse as criminal law, international and European law, business law, labor law, tax law, and private law.

A melhoria da qualidade dos cuidados pré-natais e dos cuidados intensivos neonatais resultaram, nas últimas décadas, numa continuada diminuição da morbilidade e da mortalidade perinatais e infantis, particularmente de recém-nascidos muito pré-termo. No entanto, há uma grande variabilidade entre unidades de saúde na decisão sobre procedimentos e intervenções, quer a nível nacional quer internacional, que se pode refletir em desigualdades nos resultados em saúde e que importa identificar e compreender. Este artigo tem como objetivos descrever: (1) o projeto europeu “Effective Perinatal Intensive Care in Europe” (EPICE); (2) o estudo piloto desenvolvido na Região Norte de Portugal para testar o protocolo e o instrumento de recolha de dados do estudo de coorte; (3) o recrutamento e amostra final da coorte EPICE-Portugal. O projeto EPICE desenvolve-se em 19 regiões de 11 Estados Membros da União Europeia e tem como objetivo investigar como o conhecimento científico é efetivamente aplicado no acompanhamento de recém-nascidos muito pré-termo, usando metodologias quantitativas e qualitativas. Em Portugal, o estudo integra todas as unidades públicas de obstetrícia e neonatologia da região Norte e de Lisboa e Vale do Tejo (LVT), bem como três unidades privadas de LVT. Os procedimentos do estudo (recrutamento e questionários) foram testados em quatro unidades hospitalares da região Norte de Portugal, através da recolha de informação do processo clínico de 21 nados-vivos, entre maio e dezembro de 2010, sobre a gravidez e os cuidados pré-natais, o parto, os cuidados neonatais e a alta hospitalar, usando um formulário estruturado. O estudo piloto permitiu testar o instrumento de recolha de dados e verificar que, em geral, a informação registada nos processos era suficiente para assegurar a implementação do projeto EPICE em Portugal. O recrutamento da coorte EPICE-Portugal decorreu entre 1 de junho de 2011 e 31 de maio de 2012, tendo sido identificados 724 nados-vivos muito pré-termo, bem como 95 interrupções médicas da gravidez e 155 mortes fetais com idade gestacional entre as 22+0 e as 31+6 semanas de gestação. Dos 724 nados-vivos, 607 tiveram alta hospitalar, tendo sido obtidos 544 (89,6%) consentimentos para as avaliações de seguimento.

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost